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Tang, P. Complete PAI-1 Deficiency. Encyclopedia. Available online: https://encyclopedia.pub/entry/6027 (accessed on 20 September 2026).
Tang P. Complete PAI-1 Deficiency. Encyclopedia. Available at: https://encyclopedia.pub/entry/6027. Accessed September 20, 2026.
Tang, Peter. "Complete PAI-1 Deficiency" Encyclopedia, https://encyclopedia.pub/entry/6027 (accessed September 20, 2026).
Tang, P. (2021, January 04). Complete PAI-1 Deficiency. In Encyclopedia. https://encyclopedia.pub/entry/6027
Tang, Peter. "Complete PAI-1 Deficiency." Encyclopedia. Web. 04 January, 2021.
Complete PAI-1 Deficiency
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/complete-plasminogen-activator-inhibitor-1-deficiency

Complete plasminogen activator inhibitor 1 deficiency (complete PAI-1 deficiency) is a disorder that causes abnormal bleeding. In people with this disorder, bleeding associated with injury can be excessive and last longer than usual.

genetic conditions

References

  1. Fay WP, Parker AC, Condrey LR, Shapiro AD. Human plasminogen activatorinhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a nullmutation in the PAI-1 gene. Blood. 1997 Jul 1;90(1):204-8.
  2. Flevaris P, Vaughan D. The Role of Plasminogen Activator Inhibitor Type-1 inFibrosis. Semin Thromb Hemost. 2017 Mar;43(2):169-177. doi:10.1055/s-0036-1586228.
  3. Heiman M, Gupta S, Khan SS, Vaughan DE, Shapiro AD. Complete PlasminogenActivator Inhibitor 1 Deficiency. 2017 Aug 3. In: Adam MP, Ardinger HH, Pagon RA,Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet].Seattle (WA): University of Washington, Seattle; 1993-2020. Available fromhttp://www.ncbi.nlm.nih.gov/books/NBK447152/
  4. Heiman M, Gupta S, Shapiro AD. The obstetric, gynaecological and fertilityimplications of homozygous PAI-1 deficiency: single-centre experience.Haemophilia. 2014 May;20(3):407-12. doi: 10.1111/hae.12313.
  5. Jankun J, Skrzypczak-Jankun E. Plasminogen activator inhibitor with very long half-life (VLHL PAI-1) can reduce bleeding in PAI-1-deficient patients.Cardiovasc Hematol Disord Drug Targets. 2013 Aug;13(2):144-50. Review.
  6. Mehta R, Shapiro AD. Plasminogen activator inhibitor type 1 deficiency.Haemophilia. 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x.Review.
  7. Minowa H, Takahashi Y, Tanaka T, Naganuma K, Ida S, Maki I, Yoshioka A. Fourcases of bleeding diathesis in children due to congenital plasminogen activatorinhibitor-1 deficiency. Haemostasis. 1999;29(5):286-91.
  8. Takahashi Y, Tanaka T, Minowa H, Ookubo Y, Sugimoto M, Nakajima M, Miyauchi Y,Yoshioka A. Hereditary partial deficiency of plasminogen activator inhibitor-1associated with a lifelong bleeding tendency. Int J Hematol. 1996 Jul;64(1):61-8.
  9. Yasar Yildiz S, Kuru P, Toksoy Oner E, Agirbasli M. Functional stability ofplasminogen activator inhibitor-1. ScientificWorldJournal. 2014;2014:858293. doi:10.1155/2014/858293.
  10. Zhang ZY, Wang ZY, Dong NZ, Bai X, Zhang W, Ruan CG. A case of deficiency ofplasma plasminogen activator inhibitor-1 related to Ala15Thr mutation in itssignal peptide. Blood Coagul Fibrinolysis. 2005 Jan;16(1):79-84.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
View Times: 1.3K
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 04 Jan 2021
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