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Topic Review
Miscanthus-Based Polymers
Carbon neutrality is a requisite for industrial development in modern times. The most efficient source of biomass is energy crops, and Miscanthus has been globally recognized as one of the most significant among them. Miscanthus is basically utilized for the production of heat and electric power, and it is actively displacing wood in papermaking and natural cellulose isolation technologies. However, the range of potential applications of Miscanthus is much broader.
  • 1.3K
  • 16 Oct 2023
Topic Review
Barriers to Evidence-Based Sustainable Planning for Tourism
Effective planning with a sustainable long-term vision is vital for long-term economic and social development, visitor satisfaction, improved business success, social integration, and the protection of environmental assets.  However, transitioning to a long term sustainable approach to tourism planning via the monitoring of impacts requires efficient resourcing of Local Authorities.
  • 1.3K
  • 29 Nov 2023
Topic Review
Structural Health Monitoring of Solid Rocket Motors
In the realm of space exploration, solid rocket motors (SRMs) play a pivotal role due to their reliability and high thrust-to-weight ratio. Serving as boosters in space launch vehicles and employed in military systems, and other critical & emerging applications, SRMs’ structural integrity monitoring, is of paramount importance. Traditional maintenance approaches often prove inefficient, leading to either unnecessary interventions or unexpected failures. Condition-based maintenance (CBM) emerges as a transformative strategy, incorporating advanced sensing technologies and predictive analytics. By continuously monitoring crucial parameters such as temperature, pressure, and strain, CBM enables real-time analysis, ensuring timely intervention upon detecting anomalies, thereby optimizing SRM lifecycle management. Particularly, photonic sensors and fiber-optic sensors, demonstrate exceptional promise in CBM goals. Their enhanced sensitivity and broad measurement range allow for capturing subtle changes indicative of degradation or potential failures. These sensors enable comprehensive, non-intrusive monitoring of multiple SRM locations simultaneously. Integrated with data analytics, these sensors empower predictive analysis, facilitating SRM behavior prediction and optimal maintenance planning. Ultimately, CBM, bolstered by advanced photonic sensors, promises enhanced operational availability, reduced costs, improved safety, and efficient resource allocation in SRM applications.
  • 1.3K
  • 13 Mar 2024
Topic Review
Biofuels for Spark Ignition Engines
Biofuels are receiving increased scientific attention, and recently different biofuels have been proposed for spark ignition engines. Different biofuels, mainly ethanol, methanol, i-butanol-n-butanol, and acetone, are blended together in single dual issues and evaluated as renewables for SIE. Each blend showed some advantaged and drawbacks in terms of emissions and performance. 
  • 1.3K
  • 17 Mar 2021
Topic Review
Prunus avium L.(Sweet Cherry) By-Products
Prunus avium L. (sweet cherry) is one of the most appreciated fruit due to its organoleptic and nutritional value. Interestingly, cherry leaves, stems, and flowers are agri-food by-products rich in bioactive compounds that are mostly still unexploited. Stems and leaves have been used in folk medicine since ancient times.
  • 1.3K
  • 08 Oct 2021
Topic Review
Degenerative Cervical Myelopathy
Degenerative cervical myelopathy (DCM), earlier referred to as cervical spondylotic myelopathy (CSM), is the most common and serious neurological disorder in the elderly population caused by chronic progressive compression or irritation of the spinal cord in the neck. The clinical features of DCM include localised neck pain and functional impairment of motor function in the arms, fingers and hands. If left untreated, this can lead to significant and permanent nerve damage including paralysis and death.
  • 1.3K
  • 11 May 2021
Topic Review
Calmodulin Role in Hemichannel Gating
Evidence for the existence of connexin hemichannels was first demonstrated in cultured cells expressing connexin43 by data showing that a fluorescent dye enters the cells when the extracellular calcium concentration is reduced. This was proven by evidence that the membrane resistance significantly drops when the cells are bathed in no-added-Ca2+ solution. Significantly, while external Ca2+ keeps hemichannels closed, an intracellular [Ca2+] rise opens hemichannels. Hemichannel opening is prevented by calmodulin inhibitors, suggesting that calmodulin plays a role in hemichannel gating opposite to that in gap junction channels.
  • 1.3K
  • 27 Oct 2020
Topic Review
Large Intestine Innervation during CRC
Colorectal cancer (CRC), classified as third most prevalent cancer worldwide, remains to be a clinical and research challenge. It is estimated that ~50% of CRC patients die from distant metastases. While, since the 1970s, the consensus is that tumors lack innervation, there are clear evidences of connections between the nervous system and cancer. CRC, as a tumor, possesses nerve fibres from peripheral nervous system (PNS), as part of its microenvironment, as well as axons from both branches of autonomic NS and primary sensory neurons. The structural-functional changes in enteric nervous system innervation of the tumor are important. A connection is suggested between nervous system dysfunctions and a range of neurotransmitters (Nts) (including neuropeptides, NPs), neurotrophins (Ntt) and their receptors in CRC liver metastasis (LM) development. More research is needed to understand the exact mechanisms of communication between the neurons and tumor cells.
  • 1.3K
  • 28 Oct 2020
Topic Review
Microbiota–Gut–Brain Axis
More research has recently focused on the role of the gut microbiota in the development or course of numerous diseases, including non-communicable diseases. As obesity remains prevalent, the question arises as to what microbial changes are associated with increased obesity prevalence and what kind of prevention and treatment approaches it could provide.
  • 1.3K
  • 05 Jan 2021
Topic Review
Antioxidant Properties of Second-Generation Antipsychotics
Recent studies suggest a primary role of oxidative stress in an early phase of the pathogenesis of schizophrenia and a strong neurobiological link has been found between dopaminergic system dysfunction, microglia overactivation, and oxidative stress. Different risk factors for schizophrenia increase oxidative stress phenomena raising the risk of developing psychosis. Oxidative stress induced by first-generation antipsychotics such as haloperidol significantly contributes to the development of extrapyramidal side effects. Haloperidol also exerts neurotoxic effects by decreasing antioxidant enzyme levels then worsening pro-oxidant events. Opposite to haloperidol, second-generation antipsychotics (or atypical antipsychotics) such as risperidone, clozapine, and olanzapine exert a strong antioxidant activity in experimental models of schizophrenia by rescuing the antioxidant system, with an increase in superoxide dismutase and glutathione (GSH) serum levels. Second-generation antipsychotics also improve the antioxidant status and reduce lipid peroxidation in schizophrenic patients. Interestingly, second-generation antipsychotics, such as risperidone, paliperidone, and in particular clozapine, reduce oxidative stress induced by microglia overactivation, decreasing the production of microglia-derived free radicals, finally protecting neurons against microglia-induced oxidative stress. Further, long-term clinical studies are needed to better understand the link between oxidative stress and the clinical response to antipsychotic drugs and the therapeutic potential of antioxidants to increase the response to antipsychotics. 
  • 1.3K
  • 03 Feb 2021
Topic Review
Peptide Libraries with Antimicrobial Activity
Authors describe how by coupling emerging in silico and experimental tools it is possible to create novel peptide libraries with potential antimicrobial activity. This is in response to the growing public health concern pose by multiresistant microbial strains that take millions of lives annually on a global scale. The in silico tools include emerging artificial intelligence algorithms that allow searching for novel sequences in extremely large databases. Once identified, the required membrane activity can be estimated by looking at the interactions with model lipid bilayers via molecular dynamics (MD) simulations. Experimentally, the sequences can be expressed on the surface of yeasts by the surface display technology and subsequently screened in a high-throughput manner aided by microfluidic systems capable of separating out the most active peptides by precisely monitoring changes in optical properties in-line and real-time. 
  • 1.3K
  • 24 May 2021
Topic Review
Pathogenicity in Pseudomonas aeruginosa
Pseudomonas aeruginosa has the ability to infect not only humans, but also animals and plants. Given its role as an important human pathogen, several virulence factors have been studied, as well as their regulatory systems.
  • 1.3K
  • 10 Dec 2021
Topic Review
Soil Carbon Sequestration
Carbon sequestration is the process of capturing, securing, and storing carbon dioxide from the atmosphere. Carbon is sequestered in soil by plants through photosynthesis and can be stored as soil organic carbon (SOC). The amount of SOC accumulated in RMS was mostly influenced by the restoration age, vegetation type, and substrate or type of reclamation used.
  • 1.3K
  • 20 Jan 2022
Topic Review
Helminths of Erinaceus roumanicus
Among Eulipotyphla, the Erinaceinae subfamily containing the well-known hedgehogs of Eurasia and Africa deserves special attention. The helminth fauna of the Northern white-breasted hedgehog Erinaceus roumanicus was studied in the Republic of Mordovia (Russia) for the first time. A total of 54 parasite species were recorded across Erinaceus europaeus, E. roumanicus, E. concolor and E. amurensis. Among all the studied species of hedgehogs, E. europaeus (35 species) and E. roumanicus (36) have the richest helminth faunas. The diversity of the parasite communities of Erinaceus spp. is due to the wide distribution and varied diet of these mammals. Most of the helminths found in hedgehogs are transmitted along trophic chains.
  • 1.3K
  • 14 Mar 2022
Topic Review
Micro/Nanorobots for Medical Diagnosis and Disease Treatment
Micro/nanorobots are functional devices in microns, at nanoscale, which enable efficient propulsion through chemical reactions or external physical field, including ultrasonic, optical, magnetic, and other external fields, as well as microorganisms. Compared with traditional robots, micro/nanorobots can perform various tasks on the micro/nanoscale, which has the advantages of high precision, strong flexibility, and wide adaptability. In addition, such robots can also perform tasks in a cluster manner.
  • 1.3K
  • 30 May 2022
Topic Review
Artificial Neural Networks and Energy Forecasting
Load prediction with higher accuracy and less computing power has become an important problem in the smart grids domain in general and especially in demand-side management (DSM), as it can serve to minimize global warming and better integrate renewable energies. Indeed, artificial neural networks (ANN) are the most used methods in forecasting electrical load. They are widely employed in this field for their numerous advantages. In fact, the complexity of this task is considerable due to several factors/parameters, such as weather and holidays (linear and non-linear relationships), which is a well-suited problem for ANNs and their capacity to deal with non-linear relationships.
  • 1.3K
  • 21 Jun 2022
Topic Review
Fenretinide in Cancer and Neurological Disease
Cancer and neurodegeneration share leadership as causes of morbidity and death worldwide. They can be thought as disease mechanisms at opposite ends: while in neurodegeneration, induction of inflammatory genes and suppression of cell-cycle genes are the prominent signals; the opposite happens in cancer. Fenretinide (all-trans-N-(4-hydroxyphenyl) retinamide, 4-HPR) is a synthetic derivative of all-trans-retinoic acid initially proposed in anticancer therapy for its antitumor effects combined with limited toxicity. It is also studied in many other diseases for its ability to influence several biological pathways and provide a broad spectrum of pharmacological effects.
  • 1.3K
  • 18 Jul 2022
Topic Review
Plug-in Electric Vehicles in Pennsylvania
In recent years, the popularity of electric vehicles (EVs) has increased dramatically, as numerous manufacturers now have vehicles competing in the United States EV market. The state of Pennsylvania has focused some legislation on the spread of EVs as it plans to further decrease its carbon emissions in the transportation sector. Infrastructure updates including fast charging stations, sales and tax incentives are being rolled out to help facilitate this growth. In addition, there are also some alternatives to EV's that are more fuel efficient than traditional gasoline powered vehicles.
  • 1.3K
  • 13 Oct 2022
Topic Review
Electronic Leash
An electronic leash is the pairing (“leashing”) of one or more wireless devices to a host device that allows the user to find misplaced or out-of-sight objects by activating the host device such that the “leashed” object identifies itself. The system is identical in concept to a key pager, but offers multiple codes that allow a single user-operated device to send codes to a large number of objects. Leash systems generally also offer a form of distance measurement that raises an alarm if the leashed object travels more than a selected distance from the operator. An electronic leash with a paired devices usually includes a power source, transmitter and receiver. Optional elements can include tactile, auditory, or visual indicators to help the user realize the distance traveled from the object is past the maximum. Along with the physical elements, it is very common to have a computer program or mobile application to allow for modification of factory settings of distance allowed from source to receiver and the indication of this event occurring.
  • 1.3K
  • 29 Nov 2022
Topic Review
Emotion Recognition in Conversations
As a branch of sentiment analysis tasks, emotion recognition in conversation (ERC) aims to explore the hidden emotions of a speaker by analyzing the sentiments in utterance. In addition, emotion recognition in multimodal data from conversation includes the text of the utterance and its corresponding acoustic and visual data. By integrating features from various modalities, the emotion of utterance can be more accurately predicted.
  • 1.3K
  • 29 Dec 2023
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