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Topic Review
MAPK Pathways in Cancer Metastasis
Metastasis is perhaps the most common reason for treatment failure in cancer patients, as well as the leading cause of cancer-related death. Mitogen-activated protein kinase (MAPK) are serine/threonine-protein kinases that can be activated by a variety of extracellular stimuli including growth factors, cytokines, insulin, environmental factors, and oxidative and genotoxic stress. It is becoming increasingly clear that MAPKs are involved in all the steps required for hyperproliferating cells to develop into metastatic tumors. However, scholars are currently lacking in vivo data to fully understand how MAPK signaling pathways can affect the progression of metastatic disease. 
  • 5.7K
  • 26 May 2022
Topic Review
Wearables in Higher Education
Wearable sensors have traditionally been used to measure and monitor vital human signs for well-being and healthcare applications. However, there is a growing interest in using and deploying these technologies to facilitate teaching and learning, particularly in a higher education environment. 
  • 5.7K
  • 25 Oct 2022
Topic Review
Spatial Memory
In cognitive psychology and neuroscience, spatial memory is a form of memory responsible for the recording of information about one's environment and spatial orientation. For example, a person's spatial memory is required in order to navigate around a familiar city, just as a rat's spatial memory is needed to learn the location of food at the end of a maze. It is often argued that in both humans and animals, spatial memories are summarized as a cognitive map. Spatial memory has representations within working, short-term memory and long-term memory. Research indicates that there are specific areas of the brain associated with spatial memory. Many methods are used for measuring spatial memory in children, adults, and animals.
  • 5.7K
  • 04 Nov 2022
Topic Review
Clinical Overview of Oral Cavity Cancer
Head and neck cancers are the 6th most common cancers in the United States and responsible for nearly 2% of all deaths related to cancer. Approximately 95% of all head and neck cancers are squamous cell carcinoma (SCC); of which, oral cavity SCC is the most common (excluding non-melanoma cutaneous cancers). The incidence of oral cavity cancer has gradually increased over the past 20 years. Globally, there were more than 375,000 new cases of oral cavity cancers (including cancers of the lip) and more than 175,000 deaths in 2020.
  • 5.7K
  • 10 Jan 2022
Topic Review
Maritime Southeast Asia
Maritime Southeast Asia comprises the countries of Brunei, East Timor, Indonesia, Malaysia, the Philippines and Singapore. Maritime Southeast Asia is sometimes also referred to as Island Southeast Asia, Insular Southeast Asia or Oceanic Southeast Asia. The 16th-century term "East Indies" and the later 19th-century term "Malay Archipelago" are also used to refer to Maritime Southeast Asia. In Indonesia and Malaysia, the Old Javanese term "Nusantara" is also used as a synonym for Maritime Southeast Asia. The term, however, is nationalistic and has shifting boundaries. It usually only encompasses the Malay Peninsula, the Sunda Islands, Maluku, and often Western New Guinea and excludes the Philippines . Stretching for several thousand kilometres, the area features a very large number of islands and boasts some of the richest marine, flora and fauna biodiversity on Earth. The main demographic difference that sets Maritime Southeast Asia apart from modern Mainland Southeast Asia is that its population predominantly belongs to Austronesian groups. The region contains some of the world's most highly urbanized areas—Greater Jakarta, Greater Kuala Lumpur, Metro Manila, and Singapore—and yet a majority of islands in this vast region remain uninhabited by humans.
  • 5.7K
  • 28 Nov 2022
Topic Review Peer Reviewed
Amanita muscaria: Ecology, Chemistry, Myths
Amanita muscaria is the most emblematic mushroom in the popular representation. It is an ectomycorrhizal fungus endemic to the cold ecosystems of the northern hemisphere. The basidiocarp contains isoxazoles compounds that have specific actions on the central nervous system, including hallucinations. For this reason, it is considered an important entheogenic mushroom in different cultures whose remnants are still visible in some modern-day European traditions. In Siberian civilizations, it has been consumed for religious and recreational purposes for millennia, as it was the only inebriant in this region.
  • 5.7K
  • 13 Apr 2022
Topic Review
List of Methods of Torture
A list of torture methods and devices includes:
  • 5.7K
  • 19 Oct 2022
Topic Review
Ras Al Khaimah
Ras Al Khaimah (Arabic: رأس الخيمة; IPA: [raʔs alˈxajma]), historically known as Julfar, is one of the seven emirates that make up the United Arab Emirates (UAE). The capital city and home of most residents is also called Ras Al Khaimah, sometimes abbreviated as RAK city. Its name could be taken to mean "headland of the small huts", which can be attributed to the indigenous buildings that existed along the coast. The emirate is in the northern part of the UAE, bordering Oman's exclave of Musandam. It covers an area of 2,486 km2 (960 sq mi). The emirate had a population of 210,063 at the 2005 Census, of which 41.82 percent or 87,848 were Emirati citizens. Latest estimates put the total population at between 250,000 and 300,000. Locals accounted for 97,529 in the population estimate for 2010. Its capital city RAK city has two main sections, Old Ras Al Khaimah and Nakheel, on either side of a creek. It is served by the Ras Al Khaimah International Airport. It consists of a northern part (where the city of Ras al-Khaimah is situated), and a large inland exclave in the south (near Hatta), and a few small islands in the Persian Gulf. Ras Al Khaimah has the most fertile soil in the country, due to a larger share in rainfall and underground water streams from Omani mountains.
  • 5.7K
  • 19 Oct 2022
Topic Review
Gallium Nitride High-Electron-Mobility Transistor
In recent years, GaN-based devices have been widely used in a variety of application fields. GaN-based high-electron-mobility transistors (HEMTs) are superior to conventional silicon (Si) based devices in terms of switching frequency, power rating, thermal capability and efficiency, which are crucial factors to enhance the performances of advanced power converters. This paper addresses some fundamental issues concerning intrinsic features of GaN material and key technology in practical application of GaN-based power switching devices.
  • 5.7K
  • 30 Jul 2020
Topic Review
Bharat Stage Emission Standards
Bharat stage emission standards (BSES) are emission standards instituted by the Government of India to regulate the output of air pollutants from internal combustion engines and Spark-ignition engines equipment, including motor vehicles. The standards and the timeline for implementation are set by the Central Pollution Control Board under the Ministry of Environment & Forests and climate change. The standards, based on European regulations were first introduced in 2000. Progressively stringent norms have been rolled out since then. All new vehicles manufactured after the implementation of the norms have to be compliant with the regulations. Since October 2010, Bharat Stage (BS) III norms have been enforced across the country. In 13 major cities, Bharat Stage IV emission norms have been in place since April 2010 and it has been enforced for entire country since April 2017. In 2016, the Indian government announced that the country would skip the BS-V norms altogether and adopt BS-VI norms by 2020. On November 15, 2017 The Petroleum Ministry of India in consultation with Public Oil Marketing Companies decided to bring forward the date of BS-VI grade auto fuels in NCT of Delhi with effect from April 1, 2018 instead of April 1, 2020. In fact, Petroleum Ministry OMCs were asked to examine the possibility of introduction of BS-VI auto fuels in the whole of NCR area from April 1, 2019. This huge step was taken due the heavy problem of air pollution faced by Delhi which became worse around this year. The decision was met with disarray by the automobile companies as they had planned the development according to roadmap for 2020. The phasing out of 2-stroke engine for two wheelers, the cessation of production of Maruti 800 & introduction of electronic controls have been due to the regulations related to vehicular emissions. While the norms help in bringing down pollution levels, it invariably results in increased vehicle cost due to the improved technology & higher fuel prices. However, this increase in private cost is offset by savings in health costs for the public, as there is lesser amount of disease causing particulate matter and pollution in the air. Exposure to air pollution can lead to respiratory and cardiovascular diseases, which is estimated to be the cause for 6.2 lakh early deaths in 2010, and the health cost of air pollution in India has been assessed at 3% of its GDP.
  • 5.7K
  • 09 Nov 2022
Topic Review
Porous Carbon
Porous carbons are an important class of porous materials that have grown rapidly in recent years. They have the advantages of a tunable pore structure, good physical and chemical stability, a variable specific surface, and the possibility of easy functionalization.   
  • 5.7K
  • 29 Dec 2020
Topic Review
Talkboy
Talkboy is a line of handheld voice recorder and sound novelty toys manufactured by Tiger Electronics (now owned by Hasbro) in the 1990s. The Talkboy was originally conceived as a cassette recorder and player prop for the 1992 film Home Alone 2: Lost in New York. At the request of director John Hughes and 20th Century Fox, Tiger designed and built the prop, and was given permission by the movie studio to sell a retail version of the toy. Two cassette recorders modeled after the film prop were released in 1992 and 1993, respectively. The original model did not have the variable-speed voice changer of the film version and sold only moderately during the 1992 holiday shopping season. In April 1993, Tiger released the Deluxe model, which added the voice-changing feature. Following the release of Home Alone 2 on home video in July with an insert advertising the Deluxe Talkboy, interest in the toy spiked. Retailers had severely underestimated demand, and as a result the Deluxe Talkboy was one of the most highly sought-after toys during the 1993 holiday shopping season, selling out of stores across the United States. A pink version of the cassette recorder called "Deluxe Talkgirl" was released in 1995. The success of the Talkboy cassette recorders spawned a product line of electronic toys. Tiger transitioned to digital recorders for subsequent devices, using solid-state storage and adding sound effects, beginning with "Talkboy/Talkgirl F/X+" pens in 1995, which sold more than a million units in 45 days.
  • 5.7K
  • 29 Nov 2022
Biography
Bahá'u'lláh
Bahá'u'lláh (Arabic: بهاء الله; 12 November 1817 – 29 May 1892), was a Persian religious leader and the founder of the Bahá'í Faith, which advocates universal peace and unity among all races, nations, and religions. At the age of 27, Bahá'u'lláh became a follower of the Báb, a Persian merchant who began preaching that God would soon send a new prophet similar to Jesus or Muham
  • 5.7K
  • 16 Mar 2025
Topic Review
Vulnerability of Buildings
Vulnerability is defined for buildings as the degree of loss resulting from a hazard at a certain severity level and depends on the reduction in resistance and the level of decay in the structures as a result of constant exposure to environmental factors (such as seismic actions). 
  • 5.7K
  • 23 Nov 2021
Topic Review
Neutrophils in Pregnancy, Term and Preterm Labour
Neutrophils are surveillance cells, and the first to react and migrate to sites of inflammation and infection following a chemotactic gradient. Neutrophils play a key role in both sterile inflammation and infection, performing a wide variety of effector functions such as degranulation, phagocytosis, ROS production and release of neutrophil extracellular traps (NETs). Healthy term labour requires a sterile pro-inflammatory process, whereas one of the most common causes of spontaneous preterm birth is microbial driven. Peripheral neutrophilia has long been described during pregnancy, and evidence exists demonstrating neutrophils infiltrating the cervix, uterus and foetal membranes during both term and preterm deliveries. Their presence supports a role in tissue remodelling via their effector functions.
  • 5.7K
  • 30 Oct 2022
Topic Review
Niobium Oxides
Niobium oxides (NbO, NbO2, Nb2O5), being a versatile material has achieved tremendous popularity to be used in a number of applications because of its outstanding electrical, mechanical, chemical, and magnetic properties. NbxOy films possess a direct band gap within the ranges of 3.2–4.0 eV, with these films having utility in different applications which include; optical systems, stainless steel, ceramics, solar cells, electrochromic devices, capacitor dielectrics, catalysts, sensors, and architectural requirements. With the purpose of fulfilling the requirements of a vast variety of the named applications, thin films having comprehensive properties span described by film composition, morphology, structural properties, and thickness are needed.
  • 5.7K
  • 06 Jan 2021
Topic Review
Geopolymer Concrete (GPC)
Geopolymer concrete (GPC) is a new material in the construction industry, with different chemical compositions and reactions involved in a binding material. The pozzolanic materials (industrial waste like fly ash, ground granulated blast furnace slag (GGBFS), and rice husk ash), which contain high silica and alumina, work as binding materials in the mix. The sustainable development can be achieved by employing geopolymers in construction industries, because it results in lower CO2 emissions, optimum utilization of natural resources, utilization of waste materials, low energy consumption, thermally stability, more cost-effective in long life infrastructure construction, and, socially, financial benefits and employment generation
  • 5.7K
  • 18 Apr 2022
Topic Review
Policy Evolution of Chinese New Energy Vehicle Industry
The Chinese new energy vehicle industry policy is divided into three development periods: 2004–2008—promotion policy and technological policy; 2009–2013—financial policy; and 2014–2020—charging infrastructure policy. 
  • 5.7K
  • 29 Jun 2022
Topic Review
Child-Selling
Child-selling is the practice of selling children, usually by parents, legal guardians, or subsequent masters or custodians. After a sale, when the subsequent relationship with the child is essentially non-exploitative, the usual purpose of child-selling is to permit adoption.
  • 5.7K
  • 21 Oct 2022
Topic Review
Lactic Acid Production Technologies
The lactic acid annual global market in 2020 was valued at 1.1 billion US dollars and is expected to have a compound annual growth rate (CAGR) of 8% from 2021 to 2028. Lactic acid usage in end-use industries such as pharmaceuticals, biomedicals, foods, and beverages drives demand over the forecast period. Lactic acid is produced through chemical or microbial fermentative processes.
  • 5.7K
  • 10 Mar 2023
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