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Topic Review
Status Dynamic Psychotherapy
Status dynamic psychotherapy (SDT) is an approach to psychotherapy that was created by Peter G. Ossorio at the University of Colorado in the late 1960s as part of a larger system known as "descriptive psychology". Its distinguishing characteristic is that it does not focus on the factors traditionally targeted by psychotherapy such as the client’s behaviors, cognitions, insight into unconscious factors, and patterns of interaction with significant others. Instead, it focuses on bringing about changes in clients’ statuses; i.e., the positions that they occupy in relation to everything in their worlds, including themselves and aspects of themselves. Proponents of SDT maintain:
  • 1.2K
  • 08 Nov 2022
Topic Review
Resveratrol and TGF-β Signaling Pathway
Resveratrol (Res) is a well-known natural product that can exhibit important pharmacological activities such as antioxidant, anti-diabetes, anti-tumor, and anti-inflammatory. An evaluation of its therapeutic effects demonstrates that this naturally occurring bioactive compound can target different molecular pathways to exert its pharmacological actions. Transforming growth factor-beta (TGF-β) is an important molecular pathway that is capable of regulating different cellular mechanisms such as proliferation, migration, and angiogenesis. TGF-β has been reported to be involved in the development of disorders such as diabetes, cancer, inflammatory disorders, fibrosis, cardiovascular disorders, etc. 
  • 1.2K
  • 06 Jul 2021
Topic Review
Epithelial–Mesenchymal Transition for Breast Carcinogenesis
The transforming growth factor-β (TGF-β) signaling pathway plays multiple regulatory roles in the tumorigenesis and development of cancer. TGF-β can inhibit the growth and proliferation of epithelial cells and induce apoptosis, thereby playing a role in inhibiting breast cancer. Therefore, the loss of response in epithelial cells that leads to the inhibition of cell proliferation due to TGF-β is a landmark event in tumorigenesis. As tumors progress, TGF-β can promote tumor cell invasion, metastasis, and drug resistance. At present, the above-mentioned role of TGF-β is related to the interaction of multiple signaling pathways in the cell, which can attenuate or abolish the inhibition of proliferation and apoptosis-promoting effects of TGF-β and enhance its promotion of tumor progression. 
  • 1.2K
  • 31 Aug 2021
Topic Review
Gestalt Practice
Gestalt Practice is a contemporary form of personal exploration and integration developed by Dick Price at the Esalen Institute. The objective of the practice is to become more fully aware of the process of living within a unified field of body, mind, relationship, earth and spirit. Gestalt is a German word that denotes form, shape or configuration, and connotes wholeness. Practice is an ongoing program or process of development. Gestalt Practice is an ongoing process of integrating human awareness across a broad spectrum of consciousness. Initially, Gestalt was used as a psychological term in Gestalt psychology. Then Fritz Perls, Laura Perls and Paul Goodman applied it to psychotherapy when they developed Gestalt therapy, upon which Gestalt Practice was partially based. Alan Watts, who was a mentor of Dick Price, suggested combining practices from the cultures of East and West. The writings of Nyanaponika Thera and the nearby presence of Zen Roshi Shunryu Suzuki[notes 1] were sources of Buddhist meditation practice for Price. Gestalt Practice was the term he used to describe his combination of these Eastern and Western traditions. This term distinguished the practice Price taught from both Gestalt therapy and Buddhist practice.:172
  • 1.2K
  • 03 Nov 2022
Topic Review
Remission in Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) is a progressive disease with a growing prevalence, associated with an increased risk of complications. The introduction of new classes of antidiabetic drugs into clinical practice has dramatically changed the landscape of diabetes therapy. However, despite the progress made in the pharmacotherapy of T2DM, mitigating the burden of the disease on individuals, societies and health care systems remains a challenge. Remission has emerged as a therapeutic target in T2DM, achievable through a wide range of interventions. Studies have shown that extensive lifestyle changes, such as weight reduction, bariatric surgery, and intensive glucose lowering therapy, can prompt the remission of diabetes, but some unanswered questions remain regarding its long-term effects on diabetic complications. Metabolic surgery and novel classes of glucose-lowering medications are the most effective interventions to induce weight loss and by extension remission in patients with diabetes.
  • 1.2K
  • 02 Dec 2022
Topic Review
Histamine
Histamine [2-(4-imidazolyl)-ethylamine] is a biogenic amine that was first synthesized in the early 1900s. Histamine is a biogenic amine with numerous effects on many cell types, mediated by the activation of its four different histamine receptors (H1–H4Rs).
  • 1.1K
  • 08 Nov 2022
Topic Review
Western Diet, Insulin/IGF-I Signaling Pathway and Metabolic Syndrome
The metabolic syndrome is a cluster of overlapping conditions resulting in an increased incidence of type 2 diabetes, cardiovascular disease, and cancer. In the last few decades, prevalence of the metabolic syndrome in the Western world has reached epidemic proportions and this is likely due to alterations in diet and the environment as well as decreased physical activity. The Western diet and lifestyle (Westernization) plays an important etiological role in the pathogenesis of the metabolic syndrome  by exerting negative effects on activity of the insulin–insulin-like growth factor-I (insulin–IGF-I) system. Interventions that normalize/reduce activity of the insulin–IGF-I system may play a key role in the prevention and treatment of the metabolic syndrome. For successful prevention, limitation, and treatment of the metabolic syndrome, the focus should be primarily on changing our diets and lifestyle in accordance with our genetic make-up, formed in adaptation to Paleolithic diets and lifestyles during a period of several million years of human evolution.
  • 1.1K
  • 03 Mar 2023
Topic Review
Advanced Glycation End Products in Diabetes Mellitus
Diabetes is well established as a chronic disease with a high health burden due to mortality or morbidity from the final outcomes of vascular complications. An increased duration of hyperglycemia is associated with abnormal metabolism. Advanced glycation end products (AGEs) are nonenzymatic glycated forms of free amino acids that lead to abnormal crosslinking of extra-cellular and intracellular proteins by disrupting the normal structure. Furthermore, the interaction of AGEs and their receptors induces several pathways by promoting oxidative stress and inflammation. 
  • 1.1K
  • 09 Aug 2022
Topic Review
Focal Adhesion Kinase
Small-cell lung cancer (SCLC) represents 15% of all lung cancers and it is clinically the most aggressive type, being characterized by a tendency for early metastasis, with two-thirds of the patients diagnosed with an extensive stage (ES) disease and a five-year overall survival (OS) as low as 5%. There are still no effective targeted therapies in SCLC despite improved understanding of the molecular steps leading to SCLC development and progression these last years.
  • 1.1K
  • 19 Aug 2021
Topic Review
Familial Hypercholesterolaemia
Familial hypercholesterolaemia (FH) is a common inherited cause of premature cardiovascular disease, but the majority of patients remain undiagnosed. 
  • 1.1K
  • 15 May 2021
Topic Review
Writing Therapy
Writing therapy is a form of expressive therapy that uses the act of writing and processing the written word as therapy. Writing therapy posits that writing one's feelings gradually eases feelings of emotional trauma. Writing therapeutically can take place individually or in a group and it can be administered in person with a therapist or remotely through mailing or the Internet. The field of writing therapy includes many practitioners in a variety of settings. The therapy is usually administered by a therapist or counselor. Several interventions exist online. Writing group leaders also work in hospitals with patients dealing with mental and physical illnesses. In university departments they aid student self-awareness and self-development. When administered at a distance, it is useful for those who prefer to remain personally anonymous and are not ready to disclose their most private thoughts and anxieties in a face-to-face situation. As with most forms of therapy, writing therapy is adapted and used to work with a wide range of psychoneurotic issues, including bereavement, desertion and abuse. Many of these interventions take the form of classes where clients write on specific themes chosen by their therapist or counsellor. Assignments may include writing unsent letters to selected individuals, alive or dead, followed by imagined replies from the recipient, or a dialogue with the recovering alcoholic's bottle of alcohol.
  • 1.1K
  • 28 Sep 2022
Topic Review
Placental Abruption
Placental abruption is the separation of the placenta from the lining of the uterus before childbirth. It is an infrequent perinatal complication with serious after-effects and a marked risk of maternal and fetal mortality. Despite the fact that numerous placental abruption risk factors are known, the pathophysiology of this issue is multifactorial and not entirely clear.
  • 1.1K
  • 02 Jul 2021
Topic Review
Endometriosis in Menopause
Endometriosis, an estrogen-dependent inflammatory disease characterized by the ectopic presence of endometrial tissue, has been the topic of renewed research and debate in recent years. The paradigm shift from the belief that endometriosis only affects women of reproductive age has drawn attention to endometriosis in both premenarchal and postmenopausal patients. There is still scarce information in literature regarding postmenopausal endometriosis, the mostly studied and reported being the prevalence in postmenopausal women. Yet, other important issues also need to be addressed concerning diagnosis, pathophysiology, and management.
  • 1.1K
  • 13 Jul 2021
Topic Review
AML Diagnosis and Prognosis
The development of molecular studies to define the somatic genetic alterations has revolutionized the diagnostic and therapeutic management of acute myeloid leukemia (AML). AML is a highly heterogenous disease that includes many molecular subtypes; each subtype is heterogeneous both for the presence of variable co-mutations and complex combinations of clones and subclones, changing during disease evolution and in response to treatment. The treatment of AML is changing from standardized schemes of induction and consolidation chemotherapy to tailored approaches according to molecular and genetic profiles and to targeted therapy. Several molecularly targeted therapies have been approved for the treatment of some AML patients, including mutation-specific targeted drugs such as FLT3, IDH1 and IDH2 inhibitors, mutation-independent targeted drugs such as the Bcl2 inhibitor venetoclax, the hedgehog inhibitor glasdegib and the CD33-targeted drug gemtuzumab ozogamicin. Furthermore, recent studies have shown the feasibility of a personalized medicine approach for the treatment of AML patients, where the therapy decisions are guided by the results of genomic studies. 
  • 1.1K
  • 07 Apr 2021
Topic Review
Cognitive Behavioral Analysis System of Psychotherapy
The cognitive behavioral analysis system of psychotherapy (CBASP) is a talking therapy, a synthesis model of interpersonal and cognitive and behavioral therapies developed (and patented) by James P. McCullough Jr [2000, 2006] of Virginia Commonwealth University specifically for the treatment of all varieties of DSM-IV chronic depression. CBASP is often mistakenly labeled a variant of cognitive therapy (CT) or cognitive behavioral therapy (CBT) but it is not. McCullough writes that chronic depression (i.e., depressive disorder in adults that lasts continuously for two or more years; one year continuously in adolescents), particularly the type beginning during adolescence (early-onset), is essentially a refractory "mood disorder" arising from traumatic experiences or interpersonal psychological insults delivered by the patient's significant others (nuclear or extended family). The chronic depression mood disorder, at the core, is fueled by a generalized fear of others resulting in a lifetime history of interpersonal avoidance. The disorder rarely remits without proper treatment. Some basic assumptions underlying McCullough's approach to chronic depression and its treatment as a mood disorder are briefly described below.
  • 1.1K
  • 14 Oct 2022
Topic Review
Adipose-Derived Mesenchymal Stem Cells
Adipose-derived mesenchymal stem cells (AMSCs) are more accessible and easier to collect from subcutaneous tissue, they can be collected in large quantities, with less morbidity of the patients, via lipoaspirates or adipose tissue biposy, they are easily isolated, and can simply be expanded in vitro. Moreover, AMSCs have been shown to be immunoprivileged, with low risk of rejection, and more genetically stable in long term culture, with a greater proliferative rate than BM-MSCs.
  • 1.1K
  • 14 Jan 2022
Topic Review
Medical Uses of N-Acetylcysteine
N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to glutathione. It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in poisonings. There are numerous other uses or proposed uses in medicine that are still in preclinical and clinical investigations. NAC is also used in food supplements and cosmetics. Despite its abundant use, there are projections that the NAC global market will grow in the next five years; therefore, the purpose of this work is to provide a balanced view of further uses of NAC as a dietary supplement. Although NAC is considered a safe substance, the results among clinical trials are sometimes controversial or incomplete, like for many other antioxidants. More clinical trials are underway that will improve our understanding of NAC applicability.
  • 1.1K
  • 16 Aug 2021
Topic Review
Hydrolyzable Tannins' (Castanea Sativa) Mechanism of Action
Hydrolyzable tannins (HTs) deriving from chestnuts have demonstrated, through numerous studies, the ability to exert multiple beneficial effects, including antioxidant and antimicrobial effects, on the lipid metabolism and cancer cells. The latter effect is very fascinating, since different polyphenols deriving from chestnuts were able to synergistically induce the inhibition of cancerous cells through multiple pathways. Moreover, the main mechanisms by which tannins induce antioxidant functions include: the reduction in oxidative stress, the ability to scavenge free radicals, and the modulation of specific enzymes, such as superoxide dismutase. 
  • 1.1K
  • 03 Jan 2024
Topic Review
TRPM4 in Disease
Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca2+ sensitive and permeable for monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions; it regulates membrane potential and Ca2+ homeostasis in both excitable and non-excitable cells. 
  • 1.1K
  • 25 Jul 2024
Topic Review
sST2 in Acute Heart Failure and COVID-19 Infection
As a member of the interleukin-1 receptor superfamily, the protein ST2 (alternative name for “interleukin-1 receptor-like 1”) presents with a transmembrane (ST2L) and soluble (sST2) isoforms. Since the discovery of interleukin-33 (IL-33) in 2005 as the ST2L ligand, the molecule has been deeply considered in inflammatory conditions, fibroproliferative diseases, autoimmune diseases, trauma, sepsis, and most recently and significantly in pulmonary and cardiovascular diseases. 
  • 1.1K
  • 11 Aug 2022
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