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Topic Review
Clostridium thermocellum
Clostridium thermocellum, a Gram-positive, thermophilic anaerobic bacterium, exhibits an outstanding capability for degrading cellulolytic biomass to release fermentable sugars of different lengths by means of its powerful cellulosomes. 
  • 1.3K
  • 30 Aug 2021
Topic Review
Fossil Free Future for Track Work Machinery
Fossil free future for track work machinery indicates the possibility of achieving zero direct emissions during maintenance and construction work in railways by switching to alternative drives. Current railway track work machinery is mainly operated with diesel fuel. As a result, track maintenance of Austrian Federal Railways (OeBB) amounts to nearly 9000 t CO2 equivalent per year according to calculations from Graz University of Technology. OeBB’s total length of railway lines only accounts for 0.56% of the world’s length of lines. This indicates huge potential for mitigating greenhouse gas emissions considering the need for track maintenance worldwide. Environmental concerns have led to the introduction of alternative drives in the transport sector.
  • 1.3K
  • 11 Nov 2021
Topic Review
Bruton’s Tyrosine Kinase Inhibitors in Multiple Sclerosis
B cells play a central role in the pathogenesis of multiple sclerosis (MS), as demonstrated through the success of various B cell-depleting monoclonal antibodies. Bruton’s tyrosine kinase (BTK) is a critical molecule in intracellular signaling from the receptor of B cells and receptors expressed in the cells of the innate immune system. BTK inhibitors may be a non-cell-depleting alternative to B cell modulation.
  • 1.3K
  • 12 Nov 2021
Topic Review
Oklahoma Hard Red Winter Wheat
Wheat breeding continues to be an important component of agricultural innovations in the Great Plains region of the US. Over the past century, Oklahoma’s wheat yields have increased but the productivity gains have been offset in part due to increased yield variability. The shift to improved wheat varieties has resulted in increased susceptibility to plant disease and pest pressure. While a few varieties introduced over the past few decades have dominated the wheat seed market, recent trends indicate producers are adopting a more diverse range of wheat varieties. Producers’ concerns have expanded beyond demands for high yielding varieties to include more market oriented needs to increase protein content and test weight.
  • 1.3K
  • 02 Dec 2021
Topic Review
Roles/Mechanisms of Adipokines in Development of Metabolic Syndrome
Metabolic syndrome is a cluster of metabolic indicators that increase the risk of diabetes and cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue, adipokines, play critical roles in the development of metabolic syndrome. Although the adipokines leptin and adiponectin improve insulin sensitivity, others contribute to the development of glucose intolerance, including visfatin, fetuin-A, resistin, and plasminogen activator inhibitor-1 (PAI-1). Leptin and adiponectin increase fatty acid oxidation, prevent foam cell formation, and improve lipid metabolism, while visfatin, fetuin-A, PAI-1, and resistin have pro-atherogenic properties.
  • 1.3K
  • 21 Jan 2022
Topic Review
Catalytic Adsorptive Stripping Voltammetric Determination of Germanium
In organic free aqueous solutions, germanium is present in the form of Ge(OH)4 tetrahydroxide (pH < 7) or as H3GeO4−, which dominates in alkaline media (pH > 9). In the presence of many ligands containing carboxylic, di-orthophenolic, and polyalcoholic functional groups, Ge(IV) forms stable five-membered ring chelate complexes displaying coordination number 6.
  • 1.3K
  • 17 Feb 2022
Topic Review
BioMA
Modelling frameworks are used in modelling and simulation and can consist of a software infrastructure to develop and run mathematical models. They have provided a substantial step forward in the area of biophysical modelling with respect to monolithic implementations. The separation of algorithms from data, the reusability of I/O procedures and integration services, and the isolation of modelling solutions in discrete units has brought a solid advantage in the development of simulation systems. Modelling frameworks for agriculture have evolved over time, with different approaches and targets BioMA is a software framework developed focusing on platform-independent, re-usable components, including multi-model implementations at fine granularity.
  • 1.3K
  • 30 Sep 2022
Topic Review
Gastrointestinal Bleeding Due to NOACs Use
Novel oral anticoagulants (NOACs) are drugs selective for thrombin or activated factor Xa approved for the prevention and treatment of many thromboembolic conditions. They included venous thromboembolism in patients undergoing orthopedic surgery, such as hip or knee arthroplasty, atrial fibrillation, stroke prevention in nonvalvular patients, and pulmonary embolism. NOACs, such as apixaban, edoxaban, dabigatran, rivaroxaban and betrixaban, have become an alternative to vitamin K anticoagulants (i.e., warfarin).
  • 1.3K
  • 22 Nov 2022
Topic Review
Pectin-Based Hydrogels for Drug Delivery Applications
Among the various reported biopolymer-based hydrogel drug delivery systems, pectin (Pec) is an exceptional natural polymer due to its unique functionalities and excellent properties such as biocompatibility, biodegradability, low-cost, and simple gelling capability, which has received considerable interest in the drug delivery fields. 
  • 1.3K
  • 05 Jan 2023
Topic Review
Nanogrid Architectures, Control, and Converters
Environmental issues and the global need to extend sustainable access to electricity have fostered a huge amount of research in distributed generation by renewables. The challenges posed by the widespread deployment of distributed generation by renewables, such as intermittent power generation, low inertia, the need for energy storage, etc., call for the development of smart grids serving local specific areas or buildings, referred to as microgrids and nanogrids, respectively. This has led in the last decades to the proposal and actual implementation of a wide variety of system architectures and solutions, and along with that the issue of the power converters needed for interfacing the AC grid with DC micro- or nanogrids, and for DC regulation within the latter. 
  • 1.3K
  • 08 Feb 2023
Topic Review
Mechanisms Underlying SCFAs Protective Effect on Blood–Brain Barrier
Impairment of the blood–brain barrier (BBB) integrity is implicated in the numerous neurological disorders associated with neuroinflammation, neurodegeneration and aging. Short-chain fatty acids (SCFAs), mainly acetate, butyrate and propionate, produced by anaerobic bacterial fermentation of the dietary fiber in the intestine, have a key role in the communication between the gastrointestinal tract and nervous system and are critically important for the preservation of the BBB integrity under different pathological conditions.
  • 1.3K
  • 25 Jun 2023
Topic Review
Hidden World of Gut Microbiota
Metabolites generated from the gut microbiota play an essential role in the host’s health by regulating metabolic homeostasis. A disruption in this equilibrium can lead to the emergence of numerous illnesses and their etiology. Pesticides have been shown in a few recent studies to harm the host’s gut microbiome.
  • 1.3K
  • 12 Mar 2024
Topic Review
Postoperative Myocardial Infarction after Non-Cardiac Surgery
In patients undergoing major non-cardiac surgery, perioperative myocardial infarction (PMI) is a threatened complication. Every year, not less than 300 million non-cardiac surgery interventions are performed in the world. Perioperative mortality after non-cardiac surgery is estimated at 2% in patients over 45 years of age. Cardiovascular events account for half of these deaths, and most are due to perioperative myocardial infarction (MINS). The diagnosis of postoperative myocardial infarction, before the introduction of cardiac biomarkers, was based on symptoms and electrocardiographic changes and its incidence was largely underestimated. The incidence of MINS when a standard troponin assay is used ranges between 8 and 19% but increases to 20–30% with high-sensitivity troponin assays. Higher troponin values suggesting myocardial injury, both with or without a definite diagnosis of myocardial infarction, are associated with an increase in 30-day and 1-year mortality. 
  • 1.3K
  • 20 Mar 2024
Topic Review
Aquilaria sinensis Xylem
Authors analyzed the mechanism and the process of fungal-induced agarwood formation in Aquilaria sinensis and studied the functional changes in the xylem structure after the process. The microscopic structure of the white zone, transition zone, agarwood zone, and decay zone xylem was studied. The distribution of nuclei, starch grains, soluble sugars, sesquiterpenes, fungal propagules, and mycelium in xylem tissues was investigated by histochemical analysis. The results show that the process of agarwood formation was accompanied by apoptosis of parenchyma cells such as interxylary phloem, xylem rays, and axial parenchyma. Regular changes in the conversion of starch grains to soluble sugars, the production of sesquiterpenoids, and other characteristic components of agarwood in various types of parenchyma cells were also observed. The material transformation was concentrated in the interxylary phloem, providing a structural and material basis for the formation of agarwood. It is the core part of the production of sesquiterpenoids and other characteristic products of agarwood. 
  • 1.3K
  • 18 Jan 2022
Topic Review
Geothermal Energy Reservoirs
Geothermal is a renewable energy source, but this is not as often seen as other renewable energy sources, such as solar, wind, hydro, etc. Two different types of geothermal energy sources exist in the world: (1) high entropy and (2) low enthalpy geothermal energy reservoirs. Geological characteristics and local temperature are used to classify geothermal reservoirs. 
  • 1.3K
  • 12 Dec 2022
Topic Review
HDX-MS Applications on Membrane Proteins
Understanding the higher-order structure of membrane proteins (MPs), which are vital for numerous biological processes, is crucial for comprehending their function. Although several biophysical approaches have been used to study the structure of MPs, limitations exist owing to the proteins’ dynamic nature and heterogeneity. Mass spectrometry (MS) is emerging as a powerful tool for investigating membrane protein structure and dynamics.
  • 1.3K
  • 19 May 2023
Topic Review
Calcium in Apoptosis and Cancer
Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate variations in the duration and levels of intracellular Ca2+, which may be transient or sustained. These changes are then decoded by an elaborate toolkit of Ca2+-sensors, which translate Ca2+ signal to intracellular operational cell machinery, thereby regulating numerous Ca2+-dependent physiological processes. Alterations to Ca2+ homoeostasis and signaling are often deleterious and are associated with certain pathological states, including cancer. Altered Ca2+ transmission has been implicated in a variety of processes fundamental for the uncontrolled proliferation and invasiveness of tumor cells and other processes important for cancer progression, such as the development of resistance to cancer therapies.
  • 1.3K
  • 22 Sep 2021
Topic Review
Backgrounds of Agroforestry and Social Forestry in Indonesia
Smart agroforestry (SAF) is a set of agriculture and silviculture knowledge and practices that is aimed at not only increasing profits and resilience for farmers but also improving environmental parameters, including climate change mitigation and adaptation, biodiversity enhancement, and soil and water conservation, while assuring sustainable landscape management. Indonesia has the third largest area of tropical forest as well as the second largest biodiversity and the second highest number of indigenous medicinal plants in the world. It covers 10% of the global tropical forest with 50% of the world’s biodiversity, flora, mammals, amphibians, reptiles, primates, and birds, and provides 25% of the medicinal plants for human health. Social Forestry is a sustainable forest management system implemented in state forests or private/customary forests by local or traditional indigenous communities as the main actors to improve well-being, environmental balance, and sociocultural dynamics in the form of village forests, community forestry, community plantation forests, traditional forests, and forestry partnerships. Social and economic perspectives on SF development received more attention than environmental perspectives. Economic opportunities are deemed to be the main benefit of social forestry, while social and environmental challenges seem to be the major barriers to implementation. Three main keys in the SF program are how to improve the institutional governance, forest governance, and business governance. SF management needs innovation, technology, and collaboration to provide broader benefits for communities in terms of forest land and the use of forest products.
  • 1.3K
  • 16 Aug 2022
Topic Review
Reconstituted High-Density Lipoprotein Nanoparticles
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD). Mounting evidence supports that HDLs are atheroprotective, therefore, many therapeutic approaches have been developed to increase HDL cholesterol (HDL-C) levels. Nevertheless, HDL-raising therapies, such as cholesteryl ester transfer protein (CETP) inhibitors, failed to ameliorate cardiovascular outcomes in clinical trials, thereby casting doubt on the treatment of cardiovascular disease (CVD) by increasing HDL-C levels. Therefore, HDL-targeted interventional studies were shifted to increasing the number of HDL particles capable of promoting ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux. One such approach was the development of reconstituted HDL (rHDL) particles that promote ABCA1-mediated cholesterol efflux from lipid-enriched macrophages. Here, we explore the manipulation of rHDL nanoparticles as a strategy for the treatment of CVD. In addition, we discuss technological capabilities and the challenge of relating preclinical in vivo mice research to clinical studies. Finally, by drawing lessons from developing rHDL nanoparticles, we also incorporate the viabilities and advantages of the development of a molecular imaging probe with HDL nanoparticles when applied to ASCVD, as well as gaps in technology and knowledge required for putting the HDL-targeted therapeutics into full gear.
  • 1.3K
  • 01 Nov 2020
Topic Review
Single-Chain Amphiphilic Polymeric Nanoparticles
Here, we report the creation of amphiphilic polymers based on the presence of a high-molecular weight hydrophobic poly(epichlorohydrin) backbone and hydrophobic pendant oligomeric poly(ethylene glycol) chains, whereby a combination of hydrophilicity and hydrophobicity induce folding of an individual polymer chain into a single-chain polymeric nanoparticle (SCPN) (1) at high solution concentrations, (2) without requiring addition of catalysts and additives, (3) in the absence of external stimuli, and (4) under ambient aqueous conditions. Thus, this approach can be an effective way to generate water-soluble SCPNs; this breakthrough in the development of SCPNs may enable a significant advance in enabling the broad application of biomedical fields.
  • 1.3K
  • 09 Nov 2020
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