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Topic Review
Material Passport
A material passport is a document consisting of all the materials that are included in a product or construction. It consist of a set of data describing defined characteristics of materials in products, which give them value for recovery, recycling and re-use. The core idea behind the concept is that a material passport will contribute to a more "circular economy", in which materials are being recovered, recycled and/or re-used in an open traded material market. The concept of the 'material passport’ is currently being developed by multiple parties in mainly European countries. A possible second-hand material market or material-bank could become a reality in the future. Similar concepts are being developed by several parties. Other names for the material passport are: circularity passport, cradle-to-cradle passport, product passport.
  • 1.3K
  • 11 Oct 2022
Topic Review
Primary and Acquired Resistance to Immune Checkpoint Inhibitors
Hepatocellular carcinoma (HCC) is the most common liver cancer and a relevant global health problem. Immune checkpoint inhibitors (ICIs) represent the most effective systemic treatment for HCC. However, due to primary resistance, approximately 40% of HCC patients do not achieve a disease control with ICIs. Moreover, a similar proportion will experience disease progression after an initial response caused by secondary resistance. 
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  • 18 Oct 2022
Topic Review
Very-Large-Scale Integration
User:RMCD bot/subject notice Very Large Scale Integration (VLSI) is the process of creating an integrated circuit (IC) by combining hundreds of thousands of transistors or devices into a single chip. VLSI began in the 1970s when complex semiconductor and communication technologies were being developed. The microprocessor is a VLSI device. Before the introduction of VLSI technology most ICs had a limited set of functions they could perform. An electronic circuit might consist of a CPU, ROM, RAM and other glue logic. VLSI lets IC designers add all of these into one chip.
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  • 26 Oct 2022
Topic Review
List of Conjunctions
This is a list of the Solar System's recent and forthcoming planetary conjunctions (in other words, when two planets look close together). In astronomy, a conjunction is an event, defined only when using either an equatorial or an ecliptic celestial coordinate system, in which any two astronomical objects (e.g. asteroids, moons, planets, stars) have the same celestial longitude, normally as when observed from the Earth (geocentric). In the case of a geocentric conjunction of two of the Solar System's planets, since the Solar System's planets appear to travel "along the same line" (the ecliptic), the two planets appear to an Earthbound observer as being near one another in the sky around the time of the conjunction. The list below presents instances during the period 2005–2020 in which two Solar System's planets are in conjunction according to the equatorial coordinate system (in which the celestial longitude is termed right ascension).
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  • 27 Oct 2022
Topic Review
Competency-Based Performance Management
Performance management is about achieving results in a manner that is consistent with organizational expectations. Integrating competencies within the performance management process supports the provision of feedback to employees not only on "what" they have accomplished (i.e., performance goals), but also "how" the work was performed, using competencies for providing feedback. Assessing competencies as a part of performance management is an important means of assisting employees in understanding performance expectations and enhancing competencies. Multi-source feedback, while not an HR application per se, is a method that is often used in performance management to assess and provide employees with feedback on "how" they performed their work (i.e., their demonstration of the competencies).competency
  • 1.3K
  • 04 Nov 2022
Topic Review
Environmentally Extended Input-Output Analysis
Environmentally extended input-output analysis (EEIOA) is used in environmental accounting as a tool which reflects production and consumption structures within one or several economies. As such, it is becoming an important addition to material flow accounting.
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  • 11 Nov 2022
Topic Review
Saffron Authentication and By-Products
Plants and vegetables are major sources of food bioactives. Spices and herbs are plant materials that provide a wide range of biologically active compounds. In addition to being used as sources of aroma, flavor, and color and as preservatives, spices and herbs have been used for medicinal purposes and health and wellness for centuries. Aromatic spices can be added to food in their natural state as a powder or extract. In the food industry, it is not only the active parts of vegetables or plants that are important since there are several uses for their waste or by-products as ingredients in different food formulations. Saffron is the commercial name for the dried red stigmas of the Crocus sativus L. flower. It owes its sensory and functional properties mainly to the presence of its carotenoid derivatives, synthesized throughout flowering and also during the whole production process. 
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  • 14 Nov 2022
Topic Review
Co-Redemptrix
Co-Redemptrix is a title used by some Roman Catholics for the Blessed Virgin Mary, as well as a Catholic theological concept referring to Mary's role in the redemption of all peoples. It has always been controversial and has never formed part of the dogma of the Church. According to those who use the term, Co-Redemptrix refers to a subordinate but essential participation by the Blessed Virgin Mary in redemption, notably that she gave free consent to give life to the Redeemer, which meant sharing his life, suffering, and death, which were redemptive for the world. Related to this belief is the concept of Mary as Mediatrix, which is a separate concept but regularly included by Catholics who use the title Co-Redemptrix.
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  • 22 Nov 2022
Topic Review
Properties and Applications of Geopolymer Mortar
Classic cement mortar is often utilised as a standard binding and repairing material in various engineering structures. Many scholars have addressed GPM’s viability and potential applications as a suitable replacement for regular cement mortar. Sathonsaowaphak was the first to investigate geopolymer mortar and studied the properties of bottom ash fineness, ash/liquid alkali ratio, NaOH/Na2SiO3 ratio, NaOH dosage, water to ash ratio, and superplasticiser on the behaviour in terms of workability and compressive strength of GPM. Geopolymer mortar has a mechanical strength of 24–58 MPa, and adding NaOH solution improves the workability performance of GPM without reducing strength. According to the results of Detphan and Chindaprasirt, who prepared GPC using rice husk ash and fly ash and activated by NaOH and NaSiO3 solution as a liquid for the mix, they found that the maximum strength of GPM is acquired by employing a Na2SiO3-to-NaOH mass ratio of four. Moreover, more discussion about geopolymer mortar properties is reported in the following Content.
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  • 05 Dec 2022
Topic Review
Environmentalization and Waldorf Education: Dialogues and Practices
Owing to concerns regarding degradation and exploitation of nature, different Environmental Education initiatives have been developed over the years with and in the context of basic education, aiming to help confront the environmental crisis. Based on this scenario, this study aimed to understand the environmentalization process of a Brazilian Waldorf school in dialogue with Steiner principles, as well as an analysis of the concepts and practices linked to the socio-environmental issue.
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  • 03 Jan 2023
Topic Review
The Interplay between Calcium and Reactive Oxygen Species
Mitochondria are key players in energy production, critical activity for the smooth functioning of energy-demanding organs such as the muscles, brain, and heart. Therefore, dysregulation or alterations in mitochondrial bioenergetics primarily perturb these organs. Within the cell, mitochondria are the major site of reactive oxygen species (ROS) production through the activity of different enzymes since it is one of the organelles with the major availability of oxygen.
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  • 16 Feb 2023
Topic Review
Obstacles of Alkali-Activated Binders as a Sustainable Alternative
Alkali-activated binders (AABs) are prepared from solid low- or high-calcium aluminosilicate precursors in a strongly alkaline environment, thus generating hardened binders with cement-like properties. In the contemporary literature, the issue of the necessity of distinguishing between AABs and geopolymers has been widely discussed. A geopolymer is defined as a polymer created by the partial dissolution of an aluminosilicate source in a user-friendly alkaline or acidic medium to construct three-dimensional polymeric networks. On the other hand, the mechanism for the creation of AABs is similar to that of ordinary Portland cement (OPC), where, instead of calcium silicate hydrate gel, potassium or sodium aluminosilicate hydrate is available. Davidovits makes a distinction even between a geopolymer cement and a binder, stating that cement refers to a binding system that hardens at room temperature (e.g., OPC), while a binder requires heat setting.
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  • 29 May 2023
Topic Review
Non-Pharmacological Interventions for Pain Management in Hemodialysis
Acupuncture demonstrated considerable promise as a benign and efficacious supplementary therapy for managing pain, enhancing functional capacity and muscular strength, lessening symptoms of restless leg syndrome and uremic pruritus, and bettering the quality of life (QOL) of patients on hemodialysis. Additional investigations are imperative to confirm these results and define the ideal parameters for treatment. Cognitive behavioral therapy also exhibited the potential to ameliorate diverse facets of wellness in hemodialysis patients, including social support, QOL, and mental health outcomes. Cognitive behavioral therapy (CBT) proved successful in attenuating depressive symptom severity, enhancing therapy adherence, and diminishing depression. Internet-based CBT could potentially enhance the accessibility and effectiveness of these interventions for this patient population. Relaxation techniques, encompassing progressive muscle relaxation, guided imagery, deep breathing exercises, and mindfulness meditation, appear to hold potential in managing pain, fatigue, stress, and sleep patterns, as well as in promoting well-being and QOL for hemodialysis patients. Emerging as an innovative immersive technology, virtual reality has demonstrated potential benefits in pain management for individuals undergoing hemodialysis.
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  • 23 Aug 2023
Topic Review
Robotic Surgery
The advent of robotic surgical systems had a significant impact on every surgical area, especially urology, gynecology, and general and cardiac surgery. 
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  • 30 Aug 2023
Topic Review
Ethnicity Classification
Ethnic conflicts frequently lead to violations of human rights, such as genocide and crimes against humanity, as well as economic collapse, governmental failure, environmental problems, and massive influxes of refugees. Many innocent people suffer as a result of violent ethnic conflict. People’s ethnicity can pose a threat to their safety. There have been many studies on the topic of how to categorize people by race.
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  • 19 Sep 2023
Topic Review
Student Experience and Communication during the COVID-19 Pandemic
The COVID-19 pandemic in 2020 prompted higher education institutions in the United Arab Emirates (UAE) to switch to online learning for the safety of their citizens.
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  • 21 Dec 2023
Topic Review
Brain Cancer Chemotherapy Using Monoclonal Antibody Conjugates
Central nervous system (CNS) drug delivery into the brain across the endothelium is difficult due to the blood-brain barrier (BBB), which is composed mainly of tight junctions and efflux transporters, such as multiple drug resistance 1 (MDR1) (P-glycoprotein). On the other hand, the development of anti-cancer drugs is a challenging task due to their frequent off-target side effects and the complicated mechanisms of cancer pathogenesis and progression. Brain cancer treatment options are surgery, radiation therapy, and chemotherapy. It is difficult to remove all tumor cells, even by surgical removal after a craniotomy. Accordingly, innovative brain cancer drugs are needed. Currently, antibody (Ab) drugs that show high therapeutic effects are often used clinically. Furthermore, antibody-drug conjugates (ADCs), such as trastuzumab deruxtecan, an anti-HER2 (human epidermal receptor 2) ADC with low-molecular cancer drugs through the suitable linker, have been developed. In the case of trastuzumab deruxtecan, it is internalized into cancer cells across the membrane via receptor-mediated endocytosis. Moreover, it is reported that drug delivery into the brain across the BBB was carried out via receptor-mediated transcytosis (RMT), using anti-receptor Abs as a vector against the transferrin receptor (TfR) or insulin receptor (InsR). Thus, anti-TfR ADCs with cancer drugs are promising brain cancer agents due to their precise distribution and low side effects.
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  • 20 Jul 2022
Topic Review
Secretory Immunoglobulin A Immunity in COPD
Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct respiratory diseases that share features such as the obstruction of small airways and disease flare-ups that are called exacerbations and are often caused by infections. Along the airway epithelium, immunoglobulin (Ig) A contributes to first line mucosal protection against inhaled particles and pathogens. Dimeric IgA produced by mucosal plasma cells is transported towards the apical pole of airway epithelial cells by the polymeric Ig receptor (pIgR), where it is released as secretory IgA. Secretory IgA mediates immune exclusion and promotes the clearance of pathogens from the airway surface by inhibiting their adherence to the epithelium. 
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  • 27 Jul 2022
Topic Review
May 27: Opening of the Golden Gate Bridge
On May 27, 1937, San Francisco's Golden Gate Bridge was officially opened to the public for "Pedestrian Day," marking the start of a week-long celebration known as the "Golden Gate Bridge Fiesta." This event inaugurated one of the most iconic and enduring feats of civil engineering in the 20th century. Spanning the mile-wide Golden Gate Strait—the entrance to the San Francisco Bay from the Pacific Ocean—the bridge connected San Francisco with Marin County and fundamentally reshaped transportation and regional development in California. Beyond its technical brilliance, the Golden Gate Bridge came to symbolize human ambition, resilience during economic hardship, and the transformative power of infrastructure.
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  • 22 May 2025
Topic Review
New role for insurers
The recent pandemic and the recommendations of the WHO regarding the systematic nature that will characterize the spread of the future pandemic in the world require a deep rethinking of economic-social logics. ESG (Environmental Social Governance) strategies will play a key role in all sectors to ensure sustainable development together with the reduction of social inequalities. In this context, the insurance sector cannot fail to be a proactive and resilient player.
  • 1.3K
  • 07 Dec 2020
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