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Topic Review
COVID19 Immunity To Immunology
Immunity is an important term directly related to prevent any kind of infection spreading -particularly Covid19 under this pandemic situation . The specs of immunity depends on various factors like Foods & Diets , Environment / Ecology , Good Habits , Natural Remedies like Herbs & Anti-Oxidant therapy. Now we will discuss the every aspects of Immunity for boosting it up for a natural prevention of Covid19 ! . It is our sociological consiousnrss to maintain  strictly our immune system will be strong enough to fight against this Viral Curse .In the Pandemic world of Covid19 there are 300 types of vaccine-evelopment works are ongoing . In india also we have seen SII ( Pune ) are under trial of Phase2-3 trials . AstraZeneca - Oxford university , Cansino , Pfizer are trying under trial vaccine . As we are all aware that it is a long way to  nd out the ethical trial ( Clinical eciency ) universally U.S.S.R has been under claim stage . We the common people are in good hope that the vaccination will get in success to stop such Spike Crown .Without the term immunity vaccination will not be effecrive to irradicate the viral infection .
  • 1.3K
  • 29 Oct 2020
Topic Review
Personalized Medicine in Cancer Therapy
Translational research has revolutionized how we develop new treatments for cancer patients. The change from an organ-centric concept guiding treatment choice towards deep molecular analysis, driving a personalized approach, is one of the most important advances of modern oncology. Several tools such as next generation sequencing and RNA sequencing have greatly improved the capacity to detect predictive and prognostic molecular alterations. Detection of gene mutations, amplifications, and fusions has therefore altered the history of several diseases in both a localized and metastatic setting. This shift in perspective, in which attention is focused on the specific molecular alterations of the tumor, has opened the door to personalized treatment.
  • 1.3K
  • 22 Dec 2020
Topic Review
Mast Cell Functions
Mast cells (MCs) are well-known as key effector cells of type I allergic reactions, commonly named anaphylactic responses.
  • 1.3K
  • 02 Feb 2021
Topic Review
Angiogenesis Inhibitors for Colorectal Cancer
Targeting angiogenesis, the formation of new blood vessels, is an integral part of many cancer treatments, including colorectal cancer. The overall clinical benefit is well documented but modest. It has been an ongoing task for the last decade to isolate patient and tumor characteristics instrumental in identifying the subgroups to truly benefit; so far with limited success. The introduction of immunotherapy has opened a new era for anti-angiogenic treatment, as these two therapeutic strategies seem to work in synergy. This review will highlight the clinical achievements of anti-angiogenic treatment of colorectal cancer since 2004 and elaborate on the perspectives of combining it with immunotherapy.  
  • 1.3K
  • 17 Mar 2021
Topic Review
Gut Microbiome and Liver Diseases
The important role of human gut microbiota in liver diseases has long been recognized as dysbiosis and the translocation of certain microbes from the gut to liver. With the development of high-throughput DNA sequencing, the complexity and integrity of the gut microbiome in the whole spectrum of liver diseases is emerging. Specific patterns of gut microbiota have been identified in liver diseases with different causes, including alcoholic, non-alcoholic, and virus induced liver diseases, or even at different stages, ranging from steatohepatitis, fibrosis, cirrhosis, to hepatocellular carcinoma. At the same time, the mechanism of how microbiota contributes to liver diseases goes beyond the traditional function of the gut–liver axis which could lead to liver injury and inflammation.
  • 1.3K
  • 11 May 2021
Topic Review
Regulatory SNPs
Regulatory SNPs are genetic variants that associated with various human traits and diseases map to a noncoding part of the genome and are enriched in its regulatory compartment, suggesting that many causal variants may affect gene expression. The leading mechanism of action of these SNPs consists in the alterations in the transcription factor binding via creation or disruption of transcription factor binding sites (TFBSs) or some change in the affinity of these regulatory proteins to their cognate sites.
  • 1.3K
  • 29 Jun 2021
Topic Review
Hepatitis E and Pregnancy
The adverse relationship between viral hepatitis and pregnancy in developing countries had been interpreted as a reflection of retrospectively biased hospital-based data collection by the West. However, the discovery of hepatitis E virus (HEV) as the etiological agent of an epidemic of non-A, non-B hepatitis in Kashmir, and the documenting of the increased incidence and severity of hepatitis E in pregnancy via a house-to-house survey, unmasked this unholy alliance. The pathogenesis of the association is complex and several mechanisms are under intense studies. Management is multidisciplinary and needs a close watch for the development and management of acute liver failure. The development of vaccine is seen as a breakthrough in the control of hepatitis E. 
  • 1.3K
  • 12 Oct 2021
Topic Review
Trends in Recent English-Language Literature (2015–2021)
Several recurring themes and discourses emerge within this literature, including identity/identity-politics, indigenous spiritualities and religion, and intercultural syncretisms (especially in the context of Euro–American Christianity). Many of these and other discourses intersect with notions of cultural purity and the overarching institution of Western colonialism, which significantly impacted indigenous peoples (and music) throughout the world, particularly over the course of the nineteenth and twentieth centuries. Ingalls et al. propose “musical localization” as an alternative to other syncretic discourses—namely, indigenization, contextualization, and inculturation—to better address “the complex ways music-making becomes locally useful”.
  • 1.3K
  • 15 Oct 2021
Topic Review
Caffeine and Epigallocatechin Gallate in Coffee Leaf Tea
Coffee leaf tea is prepared as an infusion of dried leaves of Coffea spp. in hot water. It is a traditional beverage in some coffee-producing countries. From the various ingredients contained in coffee leaves, only two were highlighted as possibly hazardous to human health, namely, caffeine and epigallocatechin gallate (EGCG). Depending on selection and processing (age of the leaves, drying, fermentation, roasting, etc.), coffee leaf tea may exhibit a wide variety of flavors, and its full potential is currently almost unexplored. 
  • 1.3K
  • 29 Mar 2022
Topic Review
Physiology and Pathology of Salivary Glands
Salivary glands are essential structures in the oral cavity. A variety of diseases, such as cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of these glands, greatly impacting the quality of life of patients. Understanding the cellular and molecular control of salivary glands function is highly relevant for therapeutic purposes. Three major salivary glands account for more than 90% of salivary secretion: the parotid gland (PG) is mainly composed of serous acini-secreting α-amylase-rich saliva; the sublingual gland (SL) secretes mucous, a viscous solution rich in mucins; the submandibular gland (SMG) is composed by a mixed population of acini with a mucous and serous function. 
  • 1.3K
  • 07 Feb 2022
Topic Review
Synthetic Progestins in Waste and Surface Waters
Synthetic progestins (PGs) are a large family of hormones used in continuously growing amounts in human and animal contraception and medicinal therapies. Because wastewater treatment plants (WWTPs) are unable to eradicate PGs after excretion, they are discharged into aquatic systems, where they can also be regenerated from conjugated PG metabolites. The PGs were considered of particular interest due to their wide use, activity, and hormonal derivation (from testosterone, progesterone, and spirolactone). It is concluded that PGs had been analysed in WWTPs influents and effluents and, to a lesser extent, in other matrices, including surface waters, where their concentrations range from ng/L to a few µg/L. Because of their high affinity for cell hormone receptors, PGs are endocrine disruptor compounds that may alter the reproductive fitness and development of biota.
  • 1.3K
  • 21 Apr 2022
Topic Review
Antioxidants in Arrhythmia Treatment
Antioxidants are substances that can prevent damage to cells caused by free radicals. Production of reactive oxygen species and the presence of oxidative stress play an important role in cardiac arrhythmias.
  • 1.3K
  • 15 Jun 2022
Topic Review
Marine Peptides in Prostate Cancer
Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. 
  • 1.3K
  • 29 Jul 2022
Topic Review
Tendinosis
Tendinosis means and is sometimes called chronic tendinitis, chronic tendinopathy, or chronic tendon injury. It is damage to a tendon at a cellular level (the suffix "osis" implies a pathology of chronic degeneration without inflammation). It is thought to be caused by microtears in the connective tissue in and around the tendon, leading to an increase in tendon repair cells. This may lead to reduced tensile strength, thus increasing the chance of tendon rupture. Tendinosis is often misdiagnosed as tendinitis because of the limited understanding of tendinopathies by the medical community. Classic characteristics of "tendinosis" include degenerative changes in the collagenous matrix, hypercellularity, hypervascularity, and a lack of inflammatory cells which has challenged the original misnomer "tendinitis".
  • 1.3K
  • 25 Oct 2022
Topic Review
List of Plants Used in Cherokee Ethnobotany
This is a list of plants documented to have been traditionally used by the Cherokee, and how they are used.
  • 1.3K
  • 10 Nov 2022
Topic Review
Broken/Astronomy
Astronomy (from Greek: ἀστρονομία) is a natural science that studies celestial objects and phenomena. It applies mathematics, physics, and chemistry in an effort to explain the origin of those objects and phenomena and their evolution. Objects of interest include planets, moons, stars, nebulae, galaxies, and comets; the phenomena also includes supernova explosions, gamma ray bursts, quasars, blazars, pulsars, and cosmic microwave background radiation. More generally, all phenomena that originate outside Earth's atmosphere are within the purview of astronomy. A branch of astronomy called cosmology is the study of the Universe as a whole. Astronomy is one of the oldest of the natural sciences. The early civilizations in recorded history, such as the Babylonians, Greeks, Indians, Egyptians, Nubians, Iranians, Chinese, Maya, and many ancient indigenous peoples of the Americas, performed methodical observations of the night sky. Historically, astronomy has included disciplines as diverse as astrometry, celestial navigation, observational astronomy, and the making of calendars, but professional astronomy is now often considered to be synonymous with astrophysics. Professional astronomy is split into observational and theoretical branches. Observational astronomy is focused on acquiring data from observations of astronomical objects, which is then analyzed using basic principles of physics. Theoretical astronomy is oriented toward the development of computer or analytical models to describe astronomical objects and phenomena. The two fields complement each other, with theoretical astronomy seeking to explain observational results and observations being used to confirm theoretical results. Astronomy is one of the few sciences in which amateurs still play an active role, especially in the discovery and observation of transient events. Amateur astronomers have made and contributed to many important astronomical discoveries, such as finding new comets.
  • 1.3K
  • 22 Nov 2022
Topic Review
Epigenetics of Anxiety and Stress-Related Disorders
Epigenetics of anxiety and stress-related disorders is the field studying the relationship between epigenetic modifications of genes and anxiety and stress-related disorders, including mental health disorders such as generalized anxiety disorder (GAD), post-traumatic stress disorder, obsessive-compulsive disorder (OCD), and more. Epigenetic modifications play a role in the development and heritability of these disorders and related symptoms. For example, regulation of the hypothalamus-pituitary-adrenal axis by glucocorticoids plays a major role in stress response and is known to be epigenetically regulated. As of 2015 most work has been done in animal models in laboratories, and little work has been done in humans; the work is not yet applicable to clinical psychiatry.
  • 1.3K
  • 29 Nov 2022
Topic Review
Self-Sovereign Identity Technology
Self-sovereign identity (SSI) is a set of technologies that build on core concepts in identity management, blockchain technology, and cryptography. SSI enables entities to create fraud-proof verifiable credentials and instantly verify the authenticity of a digital credential.
  • 1.3K
  • 29 Nov 2022
Topic Review
Bioplastic-Based Nanoparticles for Drug Delivery Systems
Plastics have changed human lives, finding a broad range of applications from packaging to medical devices. Biodegradable plastic materials have been introduced on the market. These polymers are biodegradable but also bioresorbable and, indeed, are fundamental tools for drug formulations, thanks to their transient ability to pass through biological barriers and concentrate in specific tissues.
  • 1.3K
  • 01 Nov 2023
Topic Review
AI-Based Conversational Large Language Models
The demand for psychological counselling has grown significantly in recent years, particularly with the global outbreak of COVID-19, which heightened the need for timely and professional mental health support. Online psychological counselling emerged as the predominant mode of providing services in response to this demand. The Psy-LLM framework, an AI-based assistive tool leveraging large language models (LLMs) for question answering in psychological consultation settings to ease the demand on mental health professions.
  • 1.3K
  • 02 Jan 2024
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