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Topic Review
Microfluidics to Study Membrane Filtration
Membrane filtration processes are best known for their application in the water, oil, and gas sectors, but also in food production they play an eminent role. Filtration processes are known to suffer from a decrease in efficiency in time due to e.g., particle deposition, also known as fouling and pore blocking. Although these processes are not very well understood at a small scale, smart engineering approaches have been used to keep membrane processes running. Microfluidic devices have been increasingly applied to study membrane filtration processes and accommodate observation and understanding of the filtration process at different scales, from nanometer to millimeter and more. In combination with microscopes and high-speed imaging, microfluidic devices allow real time observation of filtration processes.
  • 1.4K
  • 24 Nov 2020
Topic Review
Smart Grids
The Smart Grid is a modern intelligent network adapted to a new global paradigm. Intelligent systems bring together energy and information and communication technologies, improving performance, quality, generation, transmission, distribution, and marketing services. Regarding the influence of intelligent networks in the transformation of human activities, it is essential to know the resources and systems of sensors, IoT and, in general, the devices that improve people’s quality of life. Today, there is a growing need for society to take care of its health by integrating the use of technology. Human Activity Recognition (HAR) allows monitoring of people’s quality of life and, in time, more features and functionalities emerge in this area, relying on a wide repertoire of hardware and software components. Proof of this is the implementation of several solutions in indoor environments, which capture the data generated from people’s interactions with an intelligent environment. Data collected from heterogeneous sensors implemented in intelligent environments or from sensors connected to the body (wearables) are stored in datasets and the information obtained from intelligent devices is integrated into a larger set, the intelligent network that brings together an environment, a community, a city, and, in general, a joint strategy to improve the quality of technology and life in our society.
  • 1.4K
  • 07 Dec 2020
Topic Review
Essential Pentosuria
Essential pentosuria is a condition characterized by high levels of a sugar called L-xylulose in urine.
  • 1.4K
  • 25 Dec 2020
Topic Review
TGFB2 Gene
transforming growth factor beta 2
  • 1.4K
  • 25 Dec 2020
Topic Review
PIK3CA Gene
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  • 1.4K
  • 25 Dec 2020
Topic Review
Atrioventricular Septal Defect
Robert Anderson has made a huge contribution to almost all aspects of morphology and under-standing of congenital cardiac malformations, none more so than the group of anomalies that many of those in the practice of paediatric cardiology and adult congenital heart disease now call ‘Atrioventricular Septal Defect’ (AVSD). In 1982, with Anton Becker working in Amsterdam, their hallmark ‘What’s in a name?’ editorial was published in the Journal of Thoracic and Cardio-vascular Surgery. At that time most described the group of lesions as ‘atrioventricular canal mal-formation’ or ‘endocardial cushion defect’. Perhaps more significantly, the so-called ostium pri-mum defect was thought to represent a partial variant. It was also universally thought, at that time, that the left atrioventricular valve was no more than a mitral valve with a cleft in the aortic leaflet. In addition to this, lesions such as isolated cleft of the mitral valve, large ventricular septal defects opening to the inlet of the right and hearts with straddling or overriding tricuspid valve were variations of the atrioventricular canal malformation. Anderson and Becker emphasised the differences between the atrioventricular junction in the normal heart and those with a common junction for which they recommended the generic name, ‘atrioventricular septal defect’.
  • 1.4K
  • 08 Mar 2021
Topic Review
Ion Channels of Nociception
Acute pain plays the vital role protecting our health whereas chronic and pathological pain are debilitating conditions.  However molecular mechanisms of pain which are the keys for pain relief remain largely unaddressed. Nevertheless, new molecular actors with important roles in pain mechanisms are being characterized, such as the mechanosensitive Piezo ion channels. This study presents modern trends and promising advances in the field of molecular mechanisms of pain. 
  • 1.4K
  • 24 Mar 2021
Topic Review
Triazolo-Thiadiazole Derivatives
The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties. A series of 1,2,4-triazolo[3,4-b]-1,2,4-thiadiazoles was synthesized and tested for its enzyme inhibition potential and anticancer activity. The results show that 1,2,4-triazolo[3,4-b]-1,2,4-thiadiazoles display potent anticancer properties in vitro against a panel of cancer cells and in vivo efficacy in HT-29 human colon tumor xenograft in CB17 severe combined immunodeficient (SCID) mice.
  • 1.4K
  • 20 Apr 2021
Topic Review
Chitosan Nanostructures
Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. 
  • 1.4K
  • 04 Nov 2021
Topic Review
Aducanumab for Low- and Middle-Income Countries
Aducanumab is a human monoclonal antibody that works to reduce Aβ load in the brain; it is the first disease-modifying therapy to be approved for AD treatment. Current AD treatment is centered on supportive care to manage the debilitating symptoms of dementia, and pharmacotherapy goals of mainstay classes of drugs, such as cholinesterase inhibitors (ChEIs) and N-methyl-D-aspartate (NMDA) receptor antagonists, do not modify the course of the disease. A substantial proportion of patients with Alzheimer’s disease live in low- and middle-income countries (LMICs), and the debilitating effects of this disease exerts burdens on patients and caregivers in addition to the significant economic strains many nations bear.
  • 1.4K
  • 22 Mar 2022
Topic Review
NK Cells in Viral Infections
NK cells are usually defined as immune cells that belong to the innate immune response. They were described as cells capable of killing several tumour cell lines without previous antigen presentation. It was shown then that NK cells lack the TCR and BCR receptors capable of binding specific antigens, and consequently, it was assumed that these cells lack antigen recognition.
  • 1.4K
  • 12 Jan 2022
Topic Review
Procedures in Mathematical Problems and Video Games
Video game use is widespread among all age groups, from young children to older adults. The wide variety of video game genres, which are adapted to all tastes and needs, is one of the factors that makes them so attractive. In many cases, video games function as an outlet for stress associated with everyday life by providing an escape from reality. The recreational aspect of video games is more important than the educational aspect. However, the students were not aware of using the problem-solving procedures they learned at school to solve different challenges in the video games. Furthermore, overcoming video game challenges stimulates positive emotions as opposed to the negative emotions generated when solving mathematical problems. 
  • 1.4K
  • 24 Mar 2022
Topic Review
In Vitro Models of Immune Dysfunction in Space
Spaceflight affects the body on every level. Reports on astronaut health identify bone marrow remodelling and dysfunction of the innate immune system as significant health risks of long-term habitation in space. Microgravity-induced alterations of the bone marrow induce physical changes to the bone marrow stem cell niche. Downstream effects on innate immunity are expected due to impaired hematopoiesis and myelopoiesis. To date, few studies have investigated these effects in real microgravity and the sparsely available literature often reports contrasting results. This emphasizes a need for the development of physiologically relevant in vitro models of the bone marrow stem cell niche, capable of delivering appropriate sample sizes for robust statistics.
  • 1.4K
  • 07 Apr 2022
Topic Review
Materials Design for N2O/CO2 Capture and Separation
The adsorption of greenhouse gases (GHG) as a method to reduce their emissions into the atmosphere is an alternative that is easier to implement industrially and cheaper than other existing technologies, such as chemical capture, cryogenic separation, or membrane separation. The vast majority of works found in the literature have focused their efforts on capturing CO2 as it is the largest GHG.
  • 1.4K
  • 22 Feb 2023
Topic Review
Functional Roles of ISG15/ISGylation in Cancer
The protein ISG15 encoded by interferon-stimulated gene (ISG) 15 is the first identified member of the ubiquitin-like protein family and exists in the form of monomers and conjugated complexes. Like ubiquitin, ISG15 can mediate an ubiquitin-like modification by covalently modifying other proteins, known as ISGylation. There is growing evidence showing that both the free and conjugated ISG15 are involved in multiple key cellular processes, including autophagy, exosome secretion, DNA repair, immune regulation, and cancer occurrence and progression.
  • 1.4K
  • 17 Feb 2023
Topic Review
Heavy Metals Biosorption by Algae
Seaweeds are mostly used in the wastewater treatment for removing toxic heavy metals.
  • 1.4K
  • 10 Apr 2023
Topic Review
Classification of Genetic Load
The term “genetic load” refers to the accumulation of lethal and sublethal harmful mutations that significantly reduce an individual’s viability or result in their death when the mutation enters a homozygous state. Each type of genetic load in farm animals correlates with a certain type of natural or artificial selection in them. In animal husbandry, four types of genetic load are generally distinguished: mutation, immigration, segregation, and substitution.
  • 1.4K
  • 20 May 2023
Topic Review
Workflow of Materials Machine Learning for Perovskite Materials
Perovskite materials have been one of the most important research objects in materials science due to their excellent photoelectric properties as well as correspondingly complex structures. Machine learning (ML) methods have been playing an important role in the design and discovery of perovskite materials, while feature selection as a dimensionality reduction method has occupied a crucial position in the ML workflow.
  • 1.4K
  • 26 Apr 2023
Topic Review
Types of Cyber Attacks on Critical Infrastructure
Several critical infrastructures are integrating information technology into their operations, and as a result, the cyber attack surface extends over a broad range of these infrastructures. Cyber attacks have been a serious problem for industries since the early 2000s, causing significant interruptions to their ability to produce goods or offer services to their clients. The thriving cybercrime economy encompasses money laundering, black markets, and attacks on cyber-physical systems that result in service disruptions. Furthermore, extensive data breaches have compromised the personally identifiable information of millions of people.
  • 1.4K
  • 06 May 2023
Topic Review
Tannery Solid Wastes for Animal Feed
The animal food industry boasted a remarkable global trade value of USD 40.9 billion in 2021. Out of 1217 traded products, it secured the 110th spot, meaning that animal food represents a commanding presence, accounting for the top 9% of all traded commodities.
  • 1.4K
  • 20 Oct 2023
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