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Topic Review
Hypoxia-inducible Factors
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.
  • 1.4K
  • 19 Oct 2022
Topic Review
Reliability of Aluminum Electrolytic Capacitors in Cold Environments
Aluminum electrolytic capacitors (AECs) are vital in efficiently operating switched-mode power supplies (SMPSs) by regulating energy storage and voltage. These capacitors are widely used due to their high capacitance and cost-effectiveness. However, their performance at low temperatures is a critical aspect that demands a thorough investigation, particularly in applications where SMPSs are subjected to sub-zero operating conditions. 
  • 1.4K
  • 30 Aug 2023
Topic Review
Canadian Lynx
The Canadian Lynx (Lynx canadensis) is a medium-sized wildcat species native to North America, predominantly found in boreal forests and mountainous regions. Recognizable for its distinctive tufted ears, thick fur coat, and short tail, this elusive carnivore is well-adapted to cold climates and dense forest habitats. Known for its stealthy hunting prowess and preference for snowshoe hares, the Canadian Lynx plays a vital role in regulating prey populations and maintaining ecosystem balance in its range.
  • 1.4K
  • 28 Feb 2024
Topic Review
17q12 Deletion Syndrome
17q12 deletion syndrome is a condition that results from the deletion of a small piece of chromosome 17 in each cell. The deletion occurs on the long (q) arm of the chromosome at a position designated q12.
  • 1.4K
  • 23 Dec 2020
Topic Review
Yersinia Species
Yersinia spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely Y. pestis, Y. enterocolitica and Y. pseudotuberculosis. Since infective endocarditis (IE) is rarely caused by Yersinia, the management of these infections can be problematic due to the lack of experience.
  • 1.4K
  • 25 Feb 2021
Topic Review
Cyclin-Dependent Kinase Inhibitors in Hematology
Genetically altered stem or progenitor cells feature gross chromosomal abnormalities, inducing modified ability of self-renewal and abnormal hematopoiesis. Cyclin-dependent kinases (CDK) regulate cell cycle progression, transcription, DNA repair and are aberrantly expressed in hematopoietic malignancies. Incorporation of CDK inhibitors (CDKIs) into the existing therapeutic regimens therefore constitutes a promising strategy. However, the complex molecular heterogeneity and different clinical presentation is challenging for selecting the right target and defining the ideal combination to mediate long-term disease control. Preclinical and early clinical data suggest that specific CDKIs have activity in selected patients, dependent on the existing rearrangements and mutations, potentially acting as biomarkers. Indeed, CDK6, expressed in hematopoietic cells, is a direct target of MLL fusion proteins often observed in acute leukemia and thus contributes to leukemogenesis. The high frequency of aberrancies in the retinoblastoma pathway additionally warrants application of CDKIs in hematopoietic neoplasms. In this review, we describe the preclinical and clinical advances recently made in the use of CDKIs. These include the FDA-approved CDK4/6 inhibitors, traditional and novel pan-CDKIs, as well as dual kinase inhibitors. We additionally provide an overview on molecular mechanisms of response vs. resistance and discuss open questions.
  • 1.4K
  • 11 Oct 2021
Topic Review
Remediation Solutions for AMDrainage
Acid Mine Drainage (AMD) is a toxic wastewater stream formed when oxygenated water comes into contact with exposed mine rock surfaces containing sulphide minerals. The formation of AMD is most prominent in abandoned mines where water accumulates in mine shafts and pits allowing exposure to sulphide minerals. The resulting AMD is typically characterised by a low pH with high concentrations of heavy metals and dissolved sulphate. When left untreated, AMD streams can cause severe environmental degradation, including the contamination of natural water bodies, destroying aquatic life and toxifying natural habitats. AMD remediation methods can be divided into two main categories, active treatment and passive treatment methods. Active treatment methods are characterised by process inputs such as energy, chemicals, labour and automated control, whereas passive remediation technologies require minimal process inputs and are mostly self-sustaining. Passive treatment methods are typically at source constructions comprising of a combination of naturally occurring geochemical, physical and biological processes.
  • 1.4K
  • 04 Aug 2021
Topic Review
Chemotherapy-Induced Gastrointestinal Mucositis and Anti-Infective Drugs
Gastrointestinal mucositis (GI-M) is a frequently observed side effect of chemotherapy in patients with cancer that affects the gastrointestinal microenvironment and potentially drug absorption. 
  • 1.4K
  • 15 Oct 2021
Topic Review
The Effect of International Traffic on Malaria Cases
The stagnation of international traffic due to countermeasures against COVID-19 potentially reduced malaria cases by 58% in 2020 in Japan. International traffic was stagnated due to the COVID-19 pandemic, but international travel is slowly picking up from very low levels. We need to promote the preparation for the rebound of imported malaria cases in response to the normalization of international traffic.
  • 1.4K
  • 17 Jan 2022
Topic Review
Sleep Deprivation Effects on Health and Immune System
Sleep health and its adaptation to individual and environmental factors are crucial to promote physical and mental well-being across animal species.
  • 1.4K
  • 06 Mar 2023
Topic Review
Malassezia Species as Commensals in Humans
Malassezia spp. are commensals of the skin, oral/sinonasal cavity, lower respiratory and gastrointestinal tract. Eighteen species have been recovered from humans, other mammals and birds. They can also be isolated from diverse environments, suggesting an evolutionary trajectory of adaption from an ecological niche in plants and soil to the mucocutaneous ecosystem of warm-blooded vertebrates.
  • 1.4K
  • 20 Jul 2022
Topic Review
Low Rate DDoS Detection Techniques in Software-Defined Networks
Software-defined networking (SDN) is a new networking paradigm that provides centralized control, programmability, and a global view of topology in the controller. SDN is becoming more popular due to its high audibility, which also raises security and privacy concerns. SDN must be outfitted with the best security scheme to counter the evolving security attacks. A Distributed Denial-of-Service (DDoS) attack is a network attack that floods network links with illegitimate data using high-rate packet transmission. Illegitimate data traffic can overload network links, causing legitimate data to be dropped and network services to be unavailable. Low-rate Distributed Denial-of-Service (LDDoS) is a recent evolution of DDoS attack that has been emerged as one of the most serious vulnerabilities for the Internet, cloud computing platforms, the Internet of Things (IoT), and large data centers. Moreover, LDDoS attacks are more challenging to detect because this attack sends a large amount of illegitimate data that are disguised as legitimate traffic. Thus, traditional security mechanisms such as symmetric/asymmetric detection schemes that have been proposed to protect SDN from DDoS attacks may not be suitable or inefficient for detecting LDDoS attacks. 
  • 1.4K
  • 08 Aug 2022
Topic Review
Effect of Grain Size on B4C and β-SiC
Nanocrystalline materials are categorized as having average grain sizes below 100 nm with a larger volume fraction of grain boundaries (GBs), leading to significant changes in their mechanical, physical, and chemical properties. Lightweight polycrystalline ceramics possess promising physical, chemical, and mechanical properties, which can be used in a variety of important structural applications. However, these ceramics with coarse-grained structures are brittle and have low fracture toughness due to their rigid covalent bonding (more often consisting of high-angle grain boundaries) that can cause catastrophic failures. Owing to these failure mechanisms in polycrystalline ceramics, a reduction in grain size to a nano-regime, which is expected to enhance the combination of hardness (or strength), toughness, and ductility, provides a promising nanomechanical research direction compared to counterpart micro-sized polycrystalline ceramics. Apart from the effects of grain size itself, the mechanical properties of B4C and SiC also show high dependency on their properties such as composition variation, anisotropy, density, etc.
  • 1.4K
  • 28 Sep 2022
Topic Review
Intelligent Speed Adaptation
Intelligent speed adaptation (ISA), also known as alerting, and intelligent authority, is any system that ensures that vehicle speed does not exceed a safe or legally enforced speed. In case of potential speeding, a human driver can be alerted, or the speed reduced automatically. Intelligent speed adaptation uses information about the road to determine the required speed. Information can be obtained from knowledge of the vehicle position, taking into account speed limits known for the position, and by interpreting road features such as signs. ISA systems are designed to detect and alert a driver when a vehicle has entered a new speed zone, or when different speed limits are in force according to time of day and conditions. Many ISA systems also provide information about driving hazards (e.g. high pedestrian movement areas, railway crossings, schools, hospitals, etc.) and limits enforced by speed and CCTV cameras at traffic lights. The purpose of ISA is to assist the driver to maintain a safe speed. Research has found that, in urban areas, the number of crashes causing casualties is doubled for each 5 km/h (3.1 mph) over the limit.
  • 1.4K
  • 27 Oct 2022
Topic Review
Comparison of High Definition Optical Disc Formats
This article compares the technical specifications of multiple high definition formats, including HD DVD and Blu-ray Disc; two mutually incompatible, high definition optical disc formats that, beginning in 2006, attempted to improve upon and eventually replace the DVD standard. The two formats remained in a format war until February 19, 2008 when Toshiba, HD DVD's creator, announced plans to cease development, manufacturing and marketing of HD DVD players and recorders. Other high-definition optical disc formats were attempted, including the multi-layered red-laser Versatile Multilayer Disc and a Chinese made format called EVD. Both appear to have been abandoned by their respective developers.
  • 1.4K
  • 15 Nov 2022
Biography
Lawrence N. Shaw
Lawrence N. Shaw (August 12, 1939 – August 19, 2017) was an American physicist, curator, artist and founder of Pi Day. Shaw worked at the San Francisco science museum The Exploratorium for 33 years, performing just about every function for the museum. He was a key member of the arts and technology community in the San Francisco Bay Area. Lawrence N. Shaw was born in Washington, D.C. on Aug
  • 1.4K
  • 25 Nov 2022
Biography
Domenico Grasso
Dr. Domenico Grasso (b. 1955 Worcester, Massachusetts) was provost of the University of Delaware. Prior to holding this position, he was Vice President for Research and Dean of the Graduate College at the University of Vermont. He did his secondary school education at St. John's High School (Massachusetts) and holds a B.Sc. from Worcester Polytechnic Institute, an M.S. from Purdue University and
  • 1.4K
  • 15 Dec 2022
Topic Review
General Characteristics of Paeonia × suffruticosa
P. × suffruticosa bark root - Moutan cortex is a medicinal raw material formerly known from traditional Chinese medicine (TCM) but less common in official European medicine. It was introduced for the first time in the European Pharmacopoeia Supplement 9.4 in 2018. P. × suffruticosa posses very valuable medicinal values, including antioxidant, cytoprotective, anti-cancer, anti-inflammatory, cardioprotective, anti-atherosclerotic, anti-diabetic and hepatoprotective activities. The scientific studies indicated that the profile of raw material activity is mainly due to paeonol, paeoniflorin and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose. Moreover, P. × suffruticosa finds increasing application in cosmetology due to research on its chronic dermatitis, anti-aging and brightening effects.
  • 1.4K
  • 20 Dec 2022
Topic Review
Mitigation of Peanut Allergenicity
Peanuts are the seeds of a legume crop grown for nuts and oil production. Peanut allergy has gained significant attention as a public health issue due to its increasing prevalence, high rate of sensitization, severity of the corresponding allergic symptoms, cross-reactivity with other food allergens, and lifelong persistence. Given the importance of peanuts in several sectors and taking into consideration the criticality of their high allergic potential, strategies aiming at mitigating their allergenicity are urgently needed. In this regard, most of the processing methods used to treat peanuts are categorized as either thermal or thermomechanical techniques. They differ in their effectiveness in alleviating the allergenicity, and in their capacity in preserving the structural integrity of the treated peanuts. Research data on this matter may open further perspectives for future relevant investigation ultimately aiming at producing hypoallergenic peanuts.
  • 1.4K
  • 27 Mar 2023
Topic Review
Health Effects of PM2.5
Particulate matter (PM) is a widespread air pollutant, consisting of a mixture of solid and liquid particles suspended in the air, covering a wide range of sizes and chemical compositions. Among ambient air pollutants most commonly investigated are PM with diameters < 10 μm and <2.5 μm (PM2.5, PM10).
  • 1.4K
  • 17 Apr 2023
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