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Topic Review
Out-of-Hospital Cardiac Arrest Management during the COVID-19 Pandemic
Out-of-hospital cardiac arrest (OHCA) is a prominent cause of death worldwide. As indicated by the high proportion of COVID-19 suspicion or diagnosis among patients who had OHCA, this issue could have resulted in multiple fatalities from coronavirus disease 2019 (COVID-19) occurring at home and being counted as OHCA.
  • 995
  • 13 Jan 2023
Topic Review
Safety Culture
Safety culture is considered to be the result of personal and collective attitudes, beliefs, and behaviour patterns, and it determines the commitment, willingness, style, and ability of organizations to manage health and safety issues. 
  • 994
  • 20 Aug 2021
Topic Review
Safety Management in Industry 5.0 Manufacturing
Safety management is a priority to guarantee human-centered manufacturing processes in the context of Industry 5.0, which aims to realize a safe human–machine environment based on knowledge-driven approaches. The traditional approaches for safety management in the industrial environment include staff training, regular inspections, warning signs, etc. Despite the fact that proactive measures and procedures have exceptional importance in the prevention of safety hazards, human–machine–environment coupling requires more sophisticated approaches able to provide automated, reliable, real-time, cost-effective, and adaptive hazard identification in complex manufacturing processes.
  • 991
  • 07 Mar 2024
Topic Review
Stability Modelling of mRNA Vaccine Quality
The vaccine distribution chains in several low- and middle-income countries are not adequate to facilitate the rapid delivery of high volumes of thermosensitive COVID-19 mRNA vaccines at the required low and ultra-low temperatures. COVID-19 mRNA vaccines are currently distributed along with temperature monitoring devices to track and identify deviations from predefined conditions throughout the distribution chain. These temperature readings can feed into computational models to quantify mRNA vaccine critical quality attributes (CQAs) and the remaining vaccine shelf life more accurately. Here, a kinetic modelling approach is proposed to quantify the stability-related CQAs and the remaining shelf life of mRNA vaccines. The CQA and shelf-life values can be computed based on the conditions under which the vaccines have been distributed from the manufacturing facilities via the distribution network to the vaccination centres.
  • 985
  • 28 Feb 2022
Topic Review
Exposure to PM-bound PAHs
Particulate matter (PM) is a major factor contributing to air quality deterioration that enters the atmosphere as a consequence of various natural and anthropogenic activities. In PM, polycyclic aromatic hydrocarbons (PAHs) represent a class of organic chemicals with at least two aromatic rings that are mainly directly emitted via the incomplete combustion of various organic materials. Numerous toxicological and epidemiological studies have proven adverse links between exposure to particulate matter-bound (PM-bound) PAHs and human health due to their carcinogenicity and mutagenicity. Among human exposure routes, inhalation is the main pathway regarding PM-bound PAHs in the atmosphere. Moreover, the concentrations of PM-bound PAHs differ among people, microenvironment, and areas. Hence, understanding the behaviour of PM-bound PAHs in the atmosphere is crucial.
  • 979
  • 23 Apr 2021
Topic Review
Oxidative Stress during Pregnancy
Pregnancy is accompanied by an increased need for oxygen in the mitochondria of the placenta and a tendency to develop oxidative stress. Oxidative stress represents a disturbance in the balance of oxidation–reduction processes in the body that occurs due to the excessive production of free oxygen radicals that cellular homeostatic mechanisms are unable to neutralize. When the balance with the antioxidant system is disturbed, which happens when free oxygen radicals are in high concentrations, serious damage to biological molecules occurs, resulting in a series of pathophysiological and pathological changes, including cell death. Therefore, oxidative stress plays a significant role in the pathogenesis of many complications that can occur during pregnancy. 
  • 974
  • 02 Aug 2023
Topic Review
Work-Related Exhaustion in East and West Germany
Chronic exhaustion is a consequence of detrimental working conditions and demands, as well as inadequate coping techniques, potentially resulting in burnout. Previous research has studied occupational environment and individual factors as predictors of exhaustion. These differ between former East and West German states, the regional distinction regarding exhaustion has been neglected. 
  • 973
  • 23 Sep 2022
Topic Review
Facebook and Suicidal Behaviour
Facebook represents a new dimension for global information sharing. Suicidal behaviours and attempts are increasingly reported on Facebook. Facebook impacts on suicidal behaviours in different aspects. Announcing suicides through sharing notes or personal information may lead to the prediction of suicide but be harmful to the online audience. Live-streaming videos of suicide is another aspect that questions Facebook’s ability to monitor shared contents that can negatively affect the audience. A positive impact is helping bereaved families to share feelings and seek support online, commemorating the lost person by sharing their photos. Moreover, it can provide real-world details of everyday user behaviours, which help predict suicide risk, primarily through novel machine-learning techniques, and provide early warning and valuable help to prevent it. It can also provide a timeline of the user’s activities and state of mind before suicide. Social media can detect suicidal tendencies, support those seeking help, comfort family and friends with their grief, and provide insights via timelining the users’ activities leading to their suicide. One of the limitations was the lack of quantitative studies evaluating preventative efforts on Facebook. The creators’ commitment and the users’ social responsibility will be required to create a mentally healthy Facebook environment.
  • 968
  • 28 Oct 2022
Topic Review
Mechanisms, Techniques and Devices of Airborne Virus Detection
Airborne viruses, such as COVID-19, cause pandemics all over the world. Virus-containing particles produced by infected individuals are suspended in the air for extended periods, actually resulting in viral aerosols and the spread of infectious diseases. Aerosol collection and detection devices are essential for limiting the spread of airborne virus diseases. 
  • 966
  • 25 Apr 2023
Topic Review
Factors Influencing Vaccine Hesitancy among Visible Minority Groups
Vaccine hesitancy is one of the top ten threats to global health and is defined as the “delay in acceptance or refusal of vaccines despite availability of vaccine services”. It remains a major threat as it prevents the reduction of vaccine-preventable diseases.
  • 965
  • 29 Dec 2021
Topic Review
COVID-19 Vaccination Hesitancy among Healthcare Workers
The COVID-19 pandemic and its associated vaccine have highlighted vaccine hesitancy among healthcare workers (HCWs). Vaccine hesitancy among this group existed prior to the pandemic and particularly centered around influenza vaccination. Being a physician, having more advanced education, and previous vaccination habits are frequently associated with vaccine acceptance. Reasons for hesitancy include concerns about safety and efficacy, mistrust of government and institutions, waiting for more data, and feeling that personal rights are being infringed upon.
  • 962
  • 28 Apr 2023
Topic Review
HPV Vaccination among KA and Koreans
Koreans and Korean Americans (KAs) have limited HPV knowledge and awareness.
  • 961
  • 05 Jan 2022
Topic Review
Pollutants Generated in Piggeries
Reducing the sources of stress on farms allows for enhanced animal welfare and productivity. Aerial contaminants and pollutants that can be found in indoor animal houses are among these stressors. In Italy, the guidelines to assess animal welfare in pig farming are displayed in a protocol named “ClassyFarm”, based on European legislation. Specific indications are given on the microclimatic conditions of livestock indoor environments (temperature, relative humidity, dustiness) and air quality, especially regarding harmful gases such as ammonia (NH3) and carbon dioxide (CO2). Nevertheless, the recommended measurement techniques for dust and harmful gases are not satisfactory.
  • 960
  • 25 Jul 2023
Topic Review
Sex and COVID-19 Mortality
Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan-Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies.
  • 954
  • 08 Oct 2021
Topic Review
Environmental Stressors and the PINE Network
Both psychosocial and physical environmental stressors have been linked to chronic mental health and chronic medical conditions. The psycho-immune-neuroendocrine (PINE) network details metabolomic pathways which are responsive to varied stressors and link chronic medical conditions with mental disorders, such as major depressive disorder via a network of pathophysiological pathways. Biological links have been established between particulate matter (PM) exposure, key sub-networks of the PINE model and mental health sequelae, suggesting that in theory, long-term mental health impacts of PM exposure may exist, driven by the disruption of these biological networks. This disruption could trans-generationally influence health; however, long-term studies and information on chronic outcomes following acute exposure event are still lacking, limiting what is known beyond the acute exposure and all-cause mortality. More empirical evidence is needed, especially to link long-term mental health sequelae to PM exposure, arising from PINE pathophysiology. 
  • 954
  • 20 Dec 2022
Topic Review
One Health, Food-Borne Zoonoses and EU Green Policies
Zoonotic agents are pathogens with an unrestricted host spectrum. In nature, their survival occurs in reservoir animal species, which generally do not present clinical symptoms and, therefore, are difficult to identify. Promiscuity between farmed animals and wildlife increases the risk of transmission of pathogens and their consequent adaptation to new host species, including human beings. Therefore, promiscuity increases the risk of emergence of new zoonoses. According to the World Organisation for Animal Health (OIE), zoonoses represent 60% of human infectious diseases and 75% of the emerging ones; 80% of pathogens of animal origin have strong potential as bioterrorism agents. Deforestation and destruction of natural areas produce promiscuity, pushing wild species to invade new areas and to arrive in anthropic environments. In high-income countries, domesticated animals are as much a potential reservoir of high-risk zoonoses as the wildlife animals in equatorial rainforests or wet markets.
  • 953
  • 22 Sep 2022
Topic Review
Walking Needs and COVID-19
More than 150 cities around the world have expanded emergency cycling and walking infrastructure to increase their resilience in the face of the COVID 19 pandemic. This tendency toward walking has led it to becoming the predominant daily mode of transport that also contributes to significant changes in the relationships between the hierarchy of walking needs and walking behaviour. These changes need to be addressed in order to increase the resilience of walking environments in the face of such a pandemic.
  • 950
  • 26 Jul 2021
Topic Review
Active Aging and Smart Public Parks
The global population is aging, with the percentage of people over 60 expected to rise from 12% to 22% and 33% residing in developed countries. However, most cities lack the appropriate infrastructure to support aging citizens in active aging and traversing the urban landscape, negatively impacting their quality of life. Studies have shown that public parks and green spaces can contribute to a higher quality of life and wellbeing. Also, smart cities are intended to improve the wellbeing and health of their inhabitants. However, most solutions are typically implemented indoors and tend to overlook the needs of older adults. A smart city should consider the increasing rate of aging and give more importance to outdoor environments as a key aspect of quality of life. 
  • 949
  • 04 Dec 2023
Topic Review
Dissecting Polygenic Etiology of Ischemic Stroke
Ischemic stroke (IS), the leading cause of death and disability worldwide, is caused by many modifiable and non-modifiable risk factors. This complex disease is also known for its multiple etiologies with moderate heritability. Polygenic risk scores (PRSs), which have been used to establish a common genetic basis for IS, may contribute to IS risk stratification for disease/outcome prediction and personalized management. Statistical modeling and machine learning algorithms have contributed significantly to this field. For instance, multiple algorithms have been successfully applied to PRS construction and integration of genetic and non-genetic features for outcome prediction to aid in risk stratification for personalized management and prevention measures. PRS derived from variants with effect size estimated based on the summary statistics of a specific subtype shows a stronger association with the matched subtype. The disruption of the extracellular matrix and amyloidosis account for the pathogenesis of cerebral small vessel disease (CSVD). Pathway-specific PRS analyses confirm known and identify novel etiologies related to IS.
  • 946
  • 20 Oct 2022
Topic Review
Sense of Coherence and Well-Being in Care Professionals
Job-related stress affects the physical and psychological health of professionals dedicated to care, and consequently affects the effectiveness of the entities for which they work. It is important to determine the relationships between a sense of coherence (SOC) and work stress and well-being perceived by care professionals. 
  • 934
  • 17 Oct 2023
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