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Topic Review
Sensors for Health Monitoring
The use of wearable equipment and sensing devices to monitor physical activities, whether for well-being, sports monitoring, or medical rehabilitation, has expanded rapidly due to the evolution of sensing techniques, cheaper integrated circuits, and the development of connectivity technologies. In this scenario, this paper presents a state-of-the-art review of sensors and systems for rehabilitation and health monitoring. Although we know the increasing importance of data processing techniques, our focus was on analyzing the implementation of sensors and biomedical applications. Although many themes overlap, we organized this review based on three groups: Sensors in Healthcare, Home Medical Assistance, and Continuous Health Monitoring; Systems and Sensors in Physical Rehabilitation; and Assistive Systems.
  • 22.5K
  • 19 Feb 2021
Topic Review
Yield
In chemistry, yield, also referred to as reaction yield, is a measure of the quantity of moles of a product formed in relation to the reactant consumed, obtained in a chemical reaction, usually expressed as a percentage. Yield is one of the primary factors that scientists must consider in organic and inorganic chemical synthesis processes. In chemical reaction engineering, "yield", "conversion" and "selectivity" are terms used to describe ratios of how much of a reactant was consumed (conversion), how much desired product was formed (yield) in relation to the undesired product (selectivity), represented as X, Y, and S.
  • 17.1K
  • 18 Oct 2022
Topic Review
Wearable Devices for Stroke Prediction
Stroke ranks as one of the top first leading causes of death and disability worldwide, particularly for the most populous countries in Asia, Europe, and North America. The emerging wearable devices intended to monitor the physiological parameters, and the growth of machine learning applied to predict diseases, are promising solutions to prevent stroke and eventually predict stroke risk.
  • 9.1K
  • 30 Sep 2021
Topic Review
Applications of polydimethylsiloxane (PDMS) in Engineering
Polydimethylsiloxane (PDMS) is an elastomer with excellent optical, electrical and mechanical properties, which makes it well-suited for several engineering applications. Due to its biocompatibility, PDMS is widely used for biomedical purposes. Some properties can be improved by adding additives.
  • 7.9K
  • 12 Jan 2022
Topic Review
Luffa Natural Fiber Composites
Natural fiber composites (NFCs) are an evolving area in polymer sciences. Fibers extracted from natural sources hold a wide set of advantages such as negligible cost, significant mechanical characteristics, low density, high strength-to-weight ratio, environmental friendliness, recyclability, etc. Luffa cylindrica, also termed luffa gourd or luffa sponge, is a natural fiber that has a solid potential to replace synthetic fibers in composite materials in diverse applications like vibration isolation, sound absorption, packaging, etc. Recently, many researches have involved luffa fibers as a reinforcement in the development of NFC, aiming to investigate their performance in selected matrices as well as the behavior of the end NFC.
  • 7.4K
  • 25 Sep 2020
Topic Review
Extraction of Peanut Skins
In addition to the edible kernel, the peanut seed consists of the woody outer shell and a paper-like substance that surrounds the kernel itself known as the testa or skin.
  • 5.7K
  • 28 Jan 2021
Topic Review
Colorimetric Sensors
Colorimetric analysis has become of great importance in recent years to improve the operationalization of plasmonic-based biosensors. The unique properties of nanomaterials have enabled the development of a variety of plasmonics applications on the basis of the colorimetric sensing provided by metal nanoparticles. In particular, the extinction of localized surface plasmon resonance (LSPR) in the visible range has permitted the exploitation of LSPR colorimetric-based biosensors as powerful tools for clinical diagnostics and drug monitoring. This review summarizes recent progress in the biochemical monitoring of clinical biomarkers by ultrasensitive plasmonic colorimetric strategies according to the distance- or the morphology/size-dependent sensing modes. Colorimetric analysis has become of great importance in recent years to improve the operationalization of plasmonic-based biosensors. The unique properties of nanomaterials have enabled the development of a variety of plasmonics applications on the basis of the colorimetric sensing provided by metal nanoparticles. In particular, the extinction of localized surface plasmon resonance (LSPR) in the visible range has permitted the exploitation of LSPR colorimetric-based biosensors as powerful tools for clinical diagnostics and drug monitoring. This review summarizes recent progress in the biochemical monitoring of clinical biomarkers by ultrasensitive plasmonic colorimetric strategies according to the distance- or the morphology/size-dependent sensing modes. 
  • 5.5K
  • 03 Nov 2020
Topic Review
Current Applications of Membrane Bioreactors
A membrane bioreactor (MBR) can be described as a chamber designed for a biochemical transformation combined with a membrane separation process. The membrane can be used for different purposes inside the bioreactor, such as the addition of a reactant or the selective removal of one of the reaction products. Moreover, membranes can be utilized to retain the biocatalyst or act as the support for the biocatalyst or for the separation of enzymes by size exclusion.
  • 5.2K
  • 21 Oct 2020
Topic Review
Biocoagulant/bioflocculant application for drinking water
The utilization of metal-based conventional coagulants/flocculants to remove suspended solids from drinking water and wastewater is currently leading to new concerns. Alarming issues related to the prolonged effects on human health and further pollution to aquatic environments from the generated nonbiodegradable sludge are becoming trending topics. The utilization of biocoagulants/bioflocculants does not produce chemical residue in the effluent and creates nonharmful, biodegradable sludge.
  • 4.5K
  • 25 Dec 2020
Topic Review
Electronic Skin
Mimicking skin sensorial properties, the development of “electronic skin” (e-skin) holds the promise of developing medical monitoring and highly sensitive prosthetic devices, biocompatible compliant medical implants, enhanced robotics, and more. The e-skin-related research field is a robust interdisciplinary approach, which combines micro-/nanoelectronics, material science, biotechnology, data transmission, and data processing technologies. The potential of epidermal electronics as biomimetic sensors, soft neural probes, prosthetics, implantable biomedical electronics, robotics, and a whole range of other skin-inspired devices show great potential to change the world. Its feasibility, however, relies on the desired e-skin characteristics such as flexibility, stretchability, self-healing ability, self-powering, biocompatibility, biodegradability and last, but not least, the reliability of large-scale manufacturing processes. 
  • 4.4K
  • 18 Oct 2021
Topic Review
Contact Lens Materials - A Materials Science Perspective
Contact lens materials are typically based on polymer- or silicone-hydrogel, with additional manufacturing technologies employed to produce the final lens. These processes are simply not enough to meet the increasing demands from CLs and the ever-increasing number of contact lens (CL) users. New materials and engineering offer increasing functionality or improved properties over previous generations.
  • 4.2K
  • 27 Jan 2022
Topic Review
Sesquiterpene Lactones
Sesquiterpene lactones, a vast group of terpenoids isolated from Asteraceae family species, exhibit a wide variety of biological activities and several of them are already available on the medicines market, such as artemisinin. Here are presented and discussed the most recent and impactful results in vivo, preclinical and clinical studies, involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) and some of their derivatives.
  • 4.1K
  • 28 Oct 2020
Topic Review
Twin-Screw Granulation
Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms. The technology has evolved rapidly due to the flexibility of the equipment design, the selection of the process variables and the wide range of processed materials. Most importantly, TSG offers the benefits of both batch and continuous manufacturing for pharmaceutical products, accompanied by excellent process control, high product quality which can be achieved through the implementation of Quality by Design (QbD) approaches and the integration of Process Analytical Tools (PAT). 
  • 4.1K
  • 18 May 2021
Topic Review
Digital twins in pharmaceutical manufacturing
The development and application of emerging technologies of Industry 4.0 enable the realization of digital twins (DT), which facilitates the transformation of the manufacturing sector to a more agile and intelligent one. DTs are virtual constructs of physical systems that mirror the behavior and dynamics of such physical systems. A fully developed DT consists of physical components, virtual components, and information communications between the two. Integrated DTs are being applied in various processes and product industries. Although the pharmaceutical industry has evolved recently to adopt Quality-by-Design (QbD) initiatives and is undergoing a paradigm shift of digitalization to embrace Industry 4.0, there has not been a full DT application in pharmaceutical manufacturing. Therefore, there is a critical need to examine the progress of the pharmaceutical industry towards implementing DT solutions. The aim of this entry is to give an overview of the current status of DT development and its application in pharmaceutical and biopharmaceutical manufacturing. State-of-the-art Process Analytical Technology (PAT) developments, process modeling approaches, and data integration studies are reviewed. Challenges and opportunities for future research in this field are also discussed.
  • 3.9K
  • 09 Mar 2022
Topic Review
Electrocardiogram Sensor
It is well-known that cardiovascular disease is one of the major causes of death worldwide nowadays. Electrocardiogram (ECG) sensor is one of the tools commonly used by cardiologists to diagnose and detect signs of heart disease with their patients. Since fast, prompt and accurate interpretation and decision is important in saving the life of patients from sudden heart attack or cardiac arrest, many innovations have been made to ECG sensors. However, the use of traditional ECG sensors is still prevalent in the clinical settings of many medical institutions.
  • 3.5K
  • 10 Feb 2021
Topic Review
Capillary-Driven Flow Microfluidics
Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patients at the point-of-need. Microfluidics plays an important role in the development of POC devices. However, requirements of handling expertise, pumping systems and complex fluidic controls make the technology unaffordable to the current healthcare systems in the world. In recent years, capillary-driven flow microfluidics has emerged as an attractive microfluidic-based technology to overcome these limitations by offering robust, cost-effective and simple-to-operate devices. The internal wall of the microchannels can be pre-coated with reagents, and by merely dipping the device into the patient sample, the sample can be loaded into the microchannel driven by capillary forces and can be detected via handheld or smartphone-based detectors. The capabilities of capillary-driven flow devices have not been fully exploited in developing POC diagnostics, especially for antimicrobial resistance studies in clinical settings. The purpose of this review is to open up this field of microfluidics to the ever-expanding microfluidic-based scientific community.
  • 3.3K
  • 24 Jul 2020
Topic Review
Surfactants versus Biosurfactants
Based on their origin and composition, surfactants can be divided into three different categories: (i) synthetic surfactants; (ii) bio-based surfactants; and (iii) microbial biosurfactants. The first group is the most widespread and cost-effective. It is composed of surfactants, which are synthetically produced, using non-renewable sources, with a final structure that is different from the natural components of living cells. The second category comprises surfactants of intermediate biocompatibility, usually produced by chemical synthesis but integrating fats, sugars or amino acids obtained from renewable sources into their structure. Finally, the third group of surfactants, designated as microbial biosurfactants, are considered the most biocompatible and eco-friendly, as they are produced by living cells, mostly bacteria and yeasts, without the intermediation of organic synthesis.
  • 3.3K
  • 14 Mar 2021
Topic Review
Blood Pressure Sensors
In our unique transdisciplinary approach, we studied the fundamentals of blood pressure and examined its measuring modalities while focusing on their clinical use and sensing principles to identify material functionalities. Then, we carefully reviewed various categories of functional materials utilized in sensor building blocks allowing for comparative analysis of the performance of a wide range of materials throughout the sensor operational-life cycle. Not only this provides essential data to enhance the materials’ properties and optimize their performance, but also, it highlights new perspectives and provides suggestions to develop the next generation pressure sensors for clinical use.
  • 3.1K
  • 10 Apr 2021
Topic Review
Applications of Quartz Crystal Microbalance
Quartz Crystal Microbalance (QCM) is one of the many acoustic transducers. It is the most popular and widely used acoustic transducer for sensor applications. It has found wide applications in chemical and biosensing fields owing to its high sensitivity, robustness, small sized-design, and ease of integration with electronic measurement systems.
  • 3.1K
  • 18 Jan 2022
Topic Review
Electrochemical Biosensors for Hormone Detection
Hormones are secreted primarily by glands or specific cells, circulate in the bloodstream, and specialize in targeting cells. The electrochemical biosensing of hormones has emerged for treating human diseases and performing clinical diagnosis.
  • 3.1K
  • 13 Jan 2021
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