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Topic Review
Psychological Manipulation
Psychological manipulation is a type of social influence that aims to change the behavior or perception of others through abusive, deceptive, or underhanded tactics. By advancing the interests of the manipulator, often at another's expense, such methods could be considered exploitative, abusive, devious, and deceptive. Social influence is not necessarily negative. For example, people such as friends, family and doctors, can try to persuade to change clearly unhelpful habits and behaviors. Social influence is generally perceived to be harmless when it respects the right of the influenced to accept or reject it, and is not unduly coercive. Depending on the context and motivations, social influence may constitute underhanded manipulation.
  • 43.0K
  • 28 Oct 2022
Topic Review
Ivermectin as Broad-Spectrum Host-Directed Antiviral
The small molecule macrocyclic lactone ivermectin, approved by the US Food and Drug Administration for parasitic infections, has received attention in the last eight years due to its exciting potential as an antiviral. It was identified in a high-throughput chemical screen as inhibiting recognition of the nuclear localizing Human Immunodeficiency Virus 1 (HIV-1) integrase protein by the host heterodimeric importin (IMP) α/β1 complex, and has since been shown to bind directly to IMPα to induce conformational changes that prevent its normal function in mediating nuclear import of key viral and host proteins. Excitingly, cell culture experiments show robust antiviral action towards HIV-1, dengue virus (DENV), Zika virus, West Nile virus, Venezuelan equine encephalitis virus, Chikungunya virus, Pseudorabies virus, adenovirus, and SARS-CoV-2 (COVID-19). Phase III human clinical trials have been completed for DENV, with >60 trials currently in progress worldwide for SARS-CoV-2.
  • 14.6K
  • 30 Sep 2020
Topic Review
Tachypsychia
Tachypsychia is a neurological condition that alters the perception of time, usually induced by physical exertion, drug use, or a traumatic event. For someone affected by tachypsychia, time perceived by the individual either lengthens, making events appear to slow down, or contracts, objects appearing as moving in a speeding blur. It is believed that tachypsychia is induced by a combination of high levels of dopamine and norepinephrine, usually during periods of great physical stress or in violent confrontation. Interestingly, a controlled experiment from 2007 suggests the subjective experience of time slowing down is actually an artifact of memory, not an actual trait of real-time perception. However, newer research seems to contradict this, with results showing that during high stress events a focus on action preparation actually does increase information processing, slowing down time perception. A 2012 review of most current research (including the 2007 study) seems to support this as well. Due to the contradictory research results and difficulty of accurately replicating the natural conditions in which the phenomenon occurs, there is still no set consensus on how tachypsychia functions.
  • 13.2K
  • 07 Nov 2022
Topic Review
World Index of Moral Freedom
{{Multiple issues| The World Index of Moral Freedom is sponsored and published by the Foundation for the Advancement of Liberty, a libertarian think tank based in Madrid, Spain . The Index is an international index ranking one hundred and sixty countries on their performance on five categories of indicators: The WIMF's first edition was published on 2 April 2016, co-authored by Foundation researchers Andreas Kohl and Juan Pina. A second edition was published by the same foundation in July 2018, this time authored by Juan Pina and Emma Watson.
  • 13.1K
  • 29 Sep 2022
Topic Review
Hormonal Breast Enhancement
Hormonal breast enhancement or augmentation is a highly experimental potential medical treatment for the breasts in which hormones or hormonal agents such as estrogen, progesterone, growth hormone (GH), and insulin-like growth factor 1 (IGF-1) are utilized or manipulated to produce breast enlargement in women. It is a possible alternative or supplement to surgical breast augmentation with breast implants or fat transfer and other means of medical breast enlargement. In addition to pharmaceuticals, some herbal breast enlargement supplements contain phytoestrogens such as 8-prenylnaringenin (found in hops) and miroestrol (a constituent of Pueraria mirifica) and thus may be regarded as a form of hormonal breast enhancement. However, evidence of their effectiveness, as well as safety data, are lacking.
  • 13.0K
  • 24 Oct 2022
Topic Review
List of Anatomy Mnemonics
This is a list of human anatomy mnemonics, categorized and alphabetized. For mnemonics in other medical specialties, see this list of medical mnemonics.
  • 10.8K
  • 24 Nov 2022
Topic Review
Timeline of Biotechnology
The historical application of biotechnology throughout time is provided below in chronological order. These discoveries, inventions and modifications are evidence of the application of biotechnology since before the common era and describe notable events in the research, development and regulation of biotechnology.
  • 10.2K
  • 05 Dec 2022
Topic Review
Physiological Effects of Marijuana
To understand the impact of marijuana on the cardiovascular system, it is imperative to understand the endocannabinoid system. The endocannabinoid system (ECS) is comprised of the endocannabinoids anandamide and 2-arachidonylglycerol (both of which are endogenous lipid mediators), their metabolic enzymes, and G-protein coupled cannabinoid receptor 1 (CB1R) plus G-protein coupled cannabinoid receptor 2 (CB2R) [24]. CB1R is the primary receptor that mediates the effects of marijuana. CB1R is present in the brain, heart, vascular smooth muscle, and peripheral nervous system [6]. Its extensive presence in the human body makes its activation wide-reaching and impacts multiple systems.
  • 10.0K
  • 06 Nov 2020
Topic Review
Shallow Affect
Reduced affect display, sometimes referred to as emotional blunting, is a condition of reduced emotional reactivity in an individual. It manifests as a failure to express feelings (affect display) either verbally or nonverbally, especially when talking about issues that would normally be expected to engage the emotions. Expressive gestures are rare and there is little animation in facial expression or vocal inflection. Reduced affect can be symptomatic of autism, schizophrenia, depression, posttraumatic stress disorder, depersonalization disorder, schizoid personality disorder or brain damage. It may also be a side effect of certain medications (e.g., antipsychotics and antidepressants). Reduced affect should be distinguished from apathy and anhedonia, which explicitly refer to a lack of emotion, whereas reduced affect is a lack of emotional expression (affect display) regardless of whether emotion (underlying affect) is actually reduced or not.
  • 9.8K
  • 24 Oct 2022
Topic Review
Protection Motivation Theory
Protection motivation theory (PMT) was originally created to help understand individual human responses to fear appeals. Protection motivation theory proposes that people protect themselves based on two factors: threat appraisal and coping appraisal. Threat appraisal assesses the severity of the situation and examines how serious the situation is, while coping appraisal is how one responds to the situation. Threat appraisal consists of the perceived severity of a threatening event and the perceived probability of the occurrence, or vulnerability. Coping appraisal consists of perceived response efficacy, or an individual's expectation that carrying out the recommended action will remove the threat, and perceived self efficacy, or the belief in one's ability to execute the recommended courses of action successfully. PMT is one model that explains why people engage in unhealthy practices and offers suggestions for changing those behaviors. It is educational and motivational. Primary prevention: taking measures to combat the risk of developing a health problem. (e.g., controlling weight to prevent high blood pressure). Secondary prevention: taking steps to prevent a condition from becoming worse. (e.g., remembering to take daily medication to control blood pressure). Another psychological model that describes self-preservation and processing of fear is terror management theory.
  • 9.1K
  • 09 Oct 2022
Topic Review
Sati (Buddhism)
Sati (from Pali: सति; Sanskrit: स्मृति smṛti) is mindfulness or awareness, a spiritual or psychological faculty (indriya) that forms an essential part of Buddhist practice. It is the first factor of the Seven Factors of Enlightenment. "Correct" or "right" mindfulness (Pali: sammā-sati, Sanskrit samyak-smṛti) is the seventh element of the Noble Eightfold Path.
  • 8.3K
  • 25 Oct 2022
Topic Review
Clouding of Consciousness
Clouding of consciousness (also known as brain fog or mental fog) is when a person is slightly less wakeful or aware than normal. They are not as aware of time or their surroundings and find it difficult to pay attention. People describe this subjective sensation as their mind being "foggy".
  • 8.3K
  • 21 Nov 2022
Topic Review
Ohaguro
Ohaguro (お歯黒) is a custom of dyeing one's teeth black. It was most popular in Japan until the Meiji era. Tooth painting is also known and practiced in the southeastern parts of China , Pacific Islands and Southeast Asia. Dyeing is mainly done by married women, though occasionally men do it as well. It was also beneficial, as it prevented tooth decay, in a similar fashion to modern dental sealants.
  • 7.2K
  • 19 Oct 2022
Topic Review
Mental Distress
Mental distress (or psychological distress) is a term used, by some mental health practitioners and users of mental health services, to describe a range of symptoms and experiences of a person's internal life that are commonly held to be troubling, confusing or out of the ordinary. Mental distress can potentially lead to a change of behavior, affect a person's emotions in a negative way, and affect their relationships with the people around them. Certain traumatic life experiences such as: bereavement, stress, lack of sleep, use of drugs or alcohol, assault, abuse or accidents can induce mental distress. This may be something which resolves without further medical intervention, though people who endure such symptoms longer term are more likely to be diagnosed with mental illness. This definition is not without controversy as some mental health practitioners would use the terms mental distress and mental illness interchangeably. Some users of mental health services prefer the term mental distress in describing their experience as they feel it better captures that sense of the unique and personal nature of their experience, while also making it easier to relate to, since everyone experiences distress at different times. The term also fits better with the social model of disability.
  • 7.1K
  • 06 Oct 2022
Topic Review
Social Construct Theory of ADHD
The social construction theory of ADHD argues that attention deficit hyperactivity disorder is not necessarily an actual pathology, but that an ADHD diagnosis is a socially constructed explanation to describe behaviors that simply do not meet prescribed social norms. Some proponents of the social construct theory of ADHD seem to regard the disorder as genuine, though over-diagnosed in some cultures. These proponents cite as evidence that the DSM IV, favored in the United States for defining and diagnosing mental illness, arrives at levels of ADHD three to four times higher than criteria in the ICD 10, the diagnostic guide favored by the World Health Organization. A popular proponent of this theory, Thomas Szasz, has argued that ADHD was "invented and not discovered."
  • 7.0K
  • 22 Nov 2022
Topic Review
Henderson–Hasselbalch Equation
In chemistry, the Henderson–Hasselbalch equation describes the derivation of pH as a measure of acidity (using pKa, the negative log of the acid dissociation constant) in biological and chemical systems. The equation is also useful for estimating the pH of a buffer solution and finding the equilibrium pH in acid-base reactions (it is widely used to calculate the isoelectric point of proteins). The equation is given by: Here, [HA] is the molar concentration of the undissociated weak acid, [A⁻] is the molar concentration (molarity, M) of this acid's conjugate base and pKa is −log10 Ka where Ka is the acid dissociation constant, that is: In these equations, A⁻ denotes the ionic form of the relevant acid. Bracketed quantities such as [base] and [acid] denote the molar concentration of the quantity enclosed.
  • 7.0K
  • 14 Oct 2022
Topic Review
Psychological Effects of Method Acting
Method acting is employed by actors to evoke realistic emotions into their performance by drawing on personal experiences. Raymond Hamden, doctor of Clinical and Forensic Psychology, defines the purpose of method acting as “compartmentalizing their own feelings while playing another character [so] they could bring the emotions of that personal feeling to cry if they needed to with that character.” However, when these emotions are not compartmentalized, they can encroach on other facets of life, often seeming to disrupt the actor’s psyche. This occurs as the actor delves into previous emotional experiences, be they joyful or traumatic. The psychological effects, like emotional fatigue, comes when suppressed or unresolved raw emotions are unburied to add to the character, not just from the employing personal emotions in performance. The question becomes whether the actor calls up resolved or unresolved emotions in their acting.
  • 6.6K
  • 16 Nov 2022
Topic Review
Plant-Dominant Low-Protein Diet
Plant-dominant low-protein diet (LPD), also abbreviated as "PLADO" is a patient-centered LPD of 0.6–0.8 g/kg/day composed of >50% plant-based sources, administered by dietitians trained in providing nutrition care to patients with non-dialysis-dependent chronic kidney disease (CKD). PLADO's composition and meal plans can be designed and adjusted based on individualized needs and according to the principles of precision nutrition. The goal of PLADO is to slow kidney disease progression, to avoid or delay dialysis therapy initiation, and to ensure cardiovascular health and longevity.  The ideal type of PLADO is a heart-healthy, safe, flexible, and feasible diet that could be the centerpiece of the conservative and preservative management of CKD.
  • 6.3K
  • 05 Nov 2020
Topic Review
List of Phobias
The English suffixes -phobia, -phobic, -phobe (from Greek φόβος phobos, "fear") occur in technical usage in psychiatry to construct words that describe irrational, abnormal, unwarranted, persistent, or disabling fear as a mental disorder (e.g. agoraphobia), in chemistry to describe chemical aversions (e.g. hydrophobic), in biology to describe organisms that dislike certain conditions (e.g. acidophobia), and in medicine to describe hypersensitivity to a stimulus, usually sensory (e.g. photophobia). In common usage, they also form words that describe dislike or hatred of a particular thing or subject (e.g. homophobia). The suffix is antonymic to -phil-. For more information on the psychiatric side, including how psychiatry groups phobias such as agoraphobia, social phobia, or simple phobia, see phobia. The following lists include words ending in -phobia, and include fears that have acquired names. In some cases, the naming of phobias has become a word game, of notable example being a 1998 humorous article published by BBC News. In some cases, a word ending in -phobia may have an antonym with the suffix -phil-, e.g. Germanophobe/Germanophile. Many -phobia lists circulate on the Internet, with words collected from indiscriminate sources, often copying each other. Also, a number of psychiatric websites exist that at the first glance cover a huge number of phobias, but in fact use a standard text to fit any phobia and reuse it for all unusual phobias by merely changing the name. Sometimes it leads to bizarre results, such as suggestions to cure "prostitute phobia". Such practice is known as content spamming and is used to attract search engines. An article published in 1897 in American Journal of Psychology noted "the absurd tendency to give Greek names to objects feared (which, as Arndt says, would give us such terms as klopsophobia – fear of thieves, triakaidekaphobia – fear of the number 13....)".
  • 6.3K
  • 07 Nov 2022
Topic Review
The Pathogenesis of Epilepsy
Epilepsy is a chronic neurological disorder characterized by recurring spontaneous seizures. Drug resistance appears in 30% of patients and it can lead to premature death, brain damage or a reduced quality of life. The purpose of the study was to analyze the drug resistance mechanisms, especially neuroinflammation, in the epileptogenesis. The information bases of biomedical literature Scopus, PubMed, Google Scholar and SciVerse were used. To obtain full-text documents, electronic resources of PubMed Central and Research Gate were used. The article examines the recent research of the mechanisms of drug resistance in epilepsy and discusses the hypotheses of drug resistance development (genetic, epigenetic, target hypothesis, etc.). Drug-resistant epilepsy is associated with neuroinflammatory, autoimmune and neurodegenerative processes. Neuroinflammation causes immune, pathophysiological, biochemical and psychological consequences. Focal or systemic unregulated inflammatory processes lead to the formation of aberrant neural connections and hyperexcitable neural networks. Inflammatory mediators affect the endothelium of cerebral vessels, destroy contacts between endothelial cells and induce abnormal angiogenesis (the formation of “leaky” vessels), thereby affecting the blood–brain barrier permeability. Thus, the analysis of pro-inflammatory and other components of epileptogenesis can contribute to the further development of the therapeutic treatment of drug-resistant epilepsy.
  • 5.7K
  • 26 May 2021
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