DISCUSSIONS :

1. Hydroxy Chloroquine – Sulphate– In generic use although Chloroquine is used as antimalerial but the Hydroxy-
Chloroquine Sulphate can also be used to reduce the inflammation during
the attack of Covid19 . Initially although the Drug was not getting approval from WHO but
later on the drug is approved by WHO .
2. Lopinavir – Rinonavir Combination ( antiviral )– This combination is used against HIV in the treatment of AIDS can be
used against Covid infection crucially .
But most efficient anti-viral against Covid19 – Remdesivir & Probably the final solution.This drug is specific to severe
acute respiratory syndrome ( SARS-COV-2 ) .
3. Flavipiravir ( antiviral ) –This drug is used against the treatment of Japanese influenza is also
used in India under the approval of DGCA , Govt of India , and Glen mark Pharmaceuticals
Ltd . This drug is a cheaper one than Remdesivir itself . It can be also used in diabetic & Hypertension patients of
Covid19 .
4. Rimantadine ( Amantadine ) – This drug is under trial but found efficient for elderly patient to treat respiratory
syndrome due to Covid19 .
5. Dexamethasone – A non anti-viral cortico-steroid used as life saving medicine ( LSM ) during severe Covid19 infection
. But it is non covid specific and also having other broad spectrum uses .
6 . Interferon – Beta – Ib – used for symptomatic Covid infections in combination with best Lopinavir – Ritonavir to
Remdesivir if necessary.
My Bibliographic Discussions: ( For detail study of structure / SAR / Q – SAR / Pharmacogical / Biological activity &
Formulations of the above noted synthetic anti-viral / non- antiviral drugs for Covid19 ) –
https://www.researchgate.net/profile/Jaydip_Datta/questions -
( Datta J , Shall we beleive that the Covid19 has a assymetric characteristics of Maleria and Crown virus ? , May 01 ,
2020 .
Datta J , Justification of Lopinavir - Ritonavir & Finally Remdesivir ( higher generation of acyclovir analog ) used in
Covid19 treatment ? , May 13 , 2020 .
Datta J , Flavipiravir - Justification of use against Covid19 ? June 21 , 2020 .
Datta J , Broad Spectrum Synthetic Antiviral Compounds ( Including covid19 ) - A Short Review ? , June ,30 ,2020 .)

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