https://doi.org/10.31219/osf.io/xw9g8

1. Hydroxy Chloroquine – Sulphate– In generic use although Chloroquine is used as antimalerial  but the Hydroxy-

Chloroquine Sulphate can also be used to reduce the inflammation during

the attack of Covid19 . Initially although the Drug was not getting approval from WHO but

later on the drug is approved by WHO .

2. Lopinavir – Rinonavir Combination ( antiviral )– This combination is used against HIV in the  treatment of AIDS can be

used against Covid infection crucially .

But most efficient anti-viral against Covid19 – Remdesivir & Probably the final solution.This drug is specific to severe acute respiratory syndrome ( SARS-COV-2 ) .

3. Flavipiravir ( antiviral ) –This drug is used against the treatment of Japanese influenza is also

used in India under the approval of DGCA , Govt of India , and Glen mark Pharmaceuticals

Ltd . This drug is a cheaper one than Remdesivir itself . It can be also used in diabetic &  Hypertension patients of Covid19 .

4. Rimantadine ( Amantadine ) – This drug is under trial but found efficient for elderly  patient to treat respiratory

syndrome due to Covid19 .

5. Dexamethasone – A non anti-viral cortico-steroid used as life saving medicine ( LSM )  during severe Covid19 infection

. But it is non covid specific and also having other  broad spectrum uses .

6 . Interferon – Beta – Ib – used for symptomatic Covid infections in combination with best  Lopinavir –    Ritonavir to

Remdesivir if necessary.7 .Remdesivir - The most effective antiviral against SARS-COV-2 used in wide spectrum in severe acute respiratory failure .

My  REF : asbmd.org        

The second Bportibliographic Don of the discussions: contains vaccine developement . 

The (vaccine For detail study of structure / SAR / Q – SAR / Pharmacogical / Biological activity & Formulations of the above noted synthetic anti-viral / non- antiviral drugs for Covid19 ) –

https://www.developement incuding trial has already started  SII ( Pune ) are under trial of Phase2-3 trials . AstraZeneca - Oxford university , Cansino , Pfizer are trying under trial vaccine . As we are all aware that it is a long way to find out the ethical trial ( clinical efficacy  ) univeresearchgate.net/profile/Jaydip_Datta/questions -

( Daally U.S.S.R has been under claim stage of Sputnik V final phase ttria J , Shall we beleivl . We the common people are in good hope that the Covid19 has a assymetric characteristics of Maleria andvaccination will get in success to stop such Spike Crown virus ? , May 01 , 2020 .

Dat.Without the term immunity vaccination will nota J , Justification of Lopinavir - Ritonavir &be effecrive to irradicate the viral infection .I

Vaccine developement under trial -1. FinallyAZD1222-A Remdesivir ( higher generation of acyclovir analog ) used in Cdecision is taken by the panel of expert of AZ Pharma willreview the unexpected of UK pateints -https://health.economictimes.indiatimes.com/tag/unexplained+illness Fovr Immunid19 treatment ? , May 13 , 2020 .

Dty booster -new formulation based on Zinc Gluconate and naturalVita J , Flavipiravir - Justification of use againstmin C coming from Acerola Cherry for boosting immunity -To accelerate vaccine workhttps://health.economictimes.indiatimes.com/tag/covid-19+drug.

2. Covid19 ? JuVaccine 21 , 2020 .

Dais tota J , Broad Spectrlly unpredictedhttps://health.economictimes.indiatimes.com/l.php?url=https%3A%2F%2Fhealth.economictimes.indiatimes.com%2Fnews%2Findum Sstrynthetic Antiviral Compounds ( Including covid19%2Ftaking-the-good-with-the-bad-how-potential-covid-19vaccines-offered-hope-and-disappointment%2F78069594&mailer_id=0&item_id=3919885&dt=2020-09-12&utm_source=Mailer&utm_medium=ET_batch&utm_campaign=ethealth_news_2020-09-12

3. A venture of Serum Institute ofIndiahttps://health.economictimes.indiatimes.com/tag/serum+institute+of+india

4.Whether Mask is an equivalent Vaccine -https://www.webmd.com/lung/news/20200909/couldyour-mask-be-a-kind-of-vaccine-against-covid-19 

5. CPT( Convalescent plasma therapy ) -Not effective to reduce thre mortality of severe Covid-infectionhttps://www.webmd.com/lung/news/20200909/could-your-mask-be-a-kind-of-vaccine-againstcovid-19" Variolation "of SARS-COV-2 -Waiting for a vaccine -10.1056/NEJMp2026913

6.Immunological response of Covid Vaccination -SARS , MERS Epidemic .

7.Article Immune responses in COVID-19 and potential vaccines: Lessons.Activated Vit-D for better Immunity .

8.Military Growing policy through vaccineresearch in Chinahttps://www.nature.com/articles/d41586-020-02523-x .

9.Chemist Martin Brooke has developed an unique test of Covid for student ofIllinois University but the infection of the Spike protein can't be stopped -https://www.npr.org/sections/healthshots/2020/08/15/902616040/can-testing-students-for-coronavirus-twice-a-week-prevent-campusoutbreaks .

10 .Please look back on Gam-COVID-Vac -https://www.raps.org/news-and-articles/newsarticles/2020/3/covid-19-vaccine-tracker

11. The third trials of AZ resumes trial in U.K-https://www.hindustantimes.com/worldnews/suspension-of-astrazeneca-covid-19-vaccine-trials-showed-fallacy-of-approach-rdif-ceo/story-rw09PX3WZQAKo1onyT6WEL.html 

12.COVISHIELD trial -https://www.timesnownews.com/health/article/covishield-update-oxfordcovid-19-vaccine-likely-to-be-the-

13 . SPUTNIK- V - This vaccines has already claimed Post registration clinical trial of SPUTNIK V for 40,000 people in Russia and Belarus has been succesfully administered without any complications -https://clinicaltrials.gov/ct2/show/NCT04437875?term=Gamaleya&draw=2&rank=2 .

14.Social cociousness to be developed for better lifestyle more immune to us against viral attack or antibody generation . Immunity is surely surely correlated for vaccination or immunological biotechnology  of SARS-COV-2 infection . The above discussion links are showing a great effort of a potent Covid -vaccination with appropiate clinical safety and efficiacy trial . Bibliographic Discussions: ( For detail study of structure / SAR / Q – SAR / Pharmacogical / Biological activity &

Formulations of the above noted synthetic anti-viral / non- antiviral drugs for Covid19 ) .

REFERENCES :

1.https://www.researchgate.net/profile/Jaydip_Datta/questions -

( Datta J , Shall we beleive that the Covid19 has a assymetric characteristics of Maleria and Crown virus ? , May 01 ,

2020 .

2.Datta J , Justification of Lopinavir - Ritonavir & Finally Remdesivir ( higher generation of acyclovir analog ) used in Covid19 treatment ? , May 13 , 2020 .

3.Datta J , Flavipiravir - Justification of use against Covid19 ? June 21 , 2020 .

4.Datta J , Broad Spectrum Synthetic Antiviral Compounds ( Including covid19 ) - A Short Review ? , June ,30 ,2020 5. https://encyclopedia.pub/1988 -COVID 19 - A PROBABLE BIBILOGRAPHIC DRUG DISCUSSIONS , Jaydip Datta ,2020.

6. )https://www.researchgate.net/post/Whether_Chemistry_Pharmacy_are_interdisciplinary-acedemics_research-updated_to_pandemic_Covid19 -Jaydip Datta A,2020.

7 S.https://www.researchgate.net/post/Whort Review ? , June ,30 ,2020at_is_fate_of_Clinical_Ethics_in_case_of_Final_trial_of_a_New_Drug - Jaydip Datta  , 2019 .)

8.Covid19 : The specs from Immunity - Datta Jaydip - https://encyclopedia.pub/1427 .

9 Datta J , researchgate.net  ( RG ) 

9.1)Do We belive that spreading & death of people by Covid 19 is due to severe damage of Environmental Sustainibility ?

( Started April 7 ) .

9.2)How Drugless therapy helps us to Improve our health as well as to prevent Viral attack ?( Started February 28 ) .

9.3 )Shall we beleive that the Covid19 has a asymmetric characteristics of Malaria and Crown virus ? ( Started May 1 ) . What is Malnutrition - Do You agree it is a Global Problem particularly in the Third world countries ? ( Asked December 11,2019 ) .

9.4 )What is GREEN HEALTH ? ( Asked December 1, 2019 ) .

9.5)What is Food adulteration - Is it a Big Problem ? ( Asked November 11 , 2019 ) What is balanced diet - Will You support that it is essential to fight agaist COVID-19 ? ( Asked November 7 , 2019 ) .

9.6)What do you prefer to take ANIMAL or VEGETABLE protein under attack of corona virus ? ( Asked October 28 , 2019 ) . Mental Frustation during LOCKDOWN period of Covid19 is more prone towards infection Share your feelings ? ( Asked December 19 , 2019 ) .

9.7)What is SLEEP ? ( Asked October 9 , 2019 ) Your favourite food as Anti-Oxidant - Let us discuss ? ( Started September 27 , 2019 ) TEA or COFFEE - Which one is good for heath ? ( Started October , 29 , 2019 ).

10.HEALTH & ENVIRONMENT: A SOCIOLOGICAL CONCIOUSNESS ( Preprint ) ,researchgate.net ( RG ) -Datta J . November 2019.

11.BALANCED DIET & ADULTERATION : An Impression ( Experimental Findings ), researchgate.net ( RG )-Datta J,  ebruary 2020 .

12. Nature@newsletter.nature.com.

13. newsletter@ethealthworld.com.

14. https://www.researchgate.net/post/Covid19 Vaccination-How far How long - Datta Jaydip .

15. https://www.researchgate.net/post/What is fate of Clinical Ethics in case of Final trial of a New Drug -

Datta Jaydip .

16. https://www.researchgate.net/post/Whether Bio-Technological Research is essential to develope our na-

tion including the threats of Corona Virus-How - Datta Jaydip .

17. https://www.researchgate.net/post/Let us Discuss something about Reproducible research technique in-

cluding COVID 19 - Datta Jaydip .

18. https://www.researchgate.net/post/What is our Knowledge or Updates about Covid19-It s source devel-

opement measurement - Datta Jaydip.

19. Covid19 Vaccine development ( ? ) { News updatate ( Preprint article ) ,  Datta Jaydip , figshare.con , Sept ,2020

20. https://www.researchgate.net/post/What_is_fate_of_Clinical_Ethics_in_case_of_Final_trial_of_a_New_Drug , Jaydip Datta.