COVID19 DRUG REVIEW DISCUSSIONS

COVID19 DRUG REVIEW DISCUSSIONS: Comparison

Please note this is a comparison between Version 4 by JAYDIP DATTA and Version 11 by JAYDIP DATTA.

In this type of note some Pprobable synthetic drugs both the Non Aantiviral as well as Anon- antiviral synthetic drugs seincluding vaccines de-velopement serving

against Covid19 commonly used under trial basis are taken into discussion .Starting from Hydroxy- Chloroquine sulphate

to Remdesivir just some points are discussed only but the in detail study regarding Structure , SAR , Q –SAR ,

Formulations Pharmacology / Bio-logical activities are available in the following BIBILOGRAPHIC discussions .Remdesivir is highlited in image since it is only effective drug against SARS-COV-2 in presense or in absence of interferon 1b .The term " Drugs " broadly classified to synthetic drugs as well as vaccines under trial .

Synthetic Antiviral
Non-antiviral
Bibilographic Discussions
Covid19
SARS-COV-2
Respiratory Syndrome
Diabetic & Hypertension
Tablet &
Intravenus Formulations
Antimalerial
Cortico-steroid
Lopinavir-Ritonavir
Remdesivir
Interferon-Beta-1b
Dexamethasone
Vaccine developement
Clinical trial

DISCUSSIONS :

1. Hydroxy Chloroquine – Sulphate– In generic use although Chloroquine is used as antimalerial but the Hydroxy-

Chloroquine Sulphate can also be used to reduce the inflammation during

the attack of Covid19 . Initially although the Drug was not getting approval from WHO but

later on the drug is approved by WHO .

2. Lopinavir – Rinonavir Combination ( antiviral )– This combination is used against HIV in the treatment of AIDS can be

used against Covid infection crucially .

But most efficient anti-viral against Covid19 – Remdesivir & Probably the final solution.This drug is specific to severe

acute respiratory syndrome ( SARS-COV-2 ) .

3. Flavipiravir ( antiviral ) –This drug is used against the treatment of Japanese influenza is also

used in India under the approval of DGCA , Govt of India , and Glen mark Pharmaceuticals

Ltd . This drug is a cheaper one than Remdesivir itself . It can be also used in diabetic & Hypertension patients of

Covid19 .

4. Rimantadine ( Amantadine ) – This drug is under trial but found efficient for elderly patient to treat respiratory

syndrome due to Covid19 .

5. Dexamethasone – A non anti-viral cortico-steroid used as life saving medicine ( LSM ) during severe Covid19 infection

. But it is non covid specific and also having other broad spectrum uses .

6 . Interferon – Beta – Ib – used for symptomatic Covid infections in combination with best Lopinavir – Ritonavir to

Remdesivir if necessary.

M7 .Remdesivir - The most effective antiviral against SARS-COV-2 used in wide spectrum in severe acute respiratory failure .

1. Hydroxy BibChliographic Discussions: ( For detail studyoroquine – Sulphate– In generic use although Chloroquine is used as antimalerial but the Hydroxy-

Chloroquine Sulphate can alsof structure / SAR / Q – SAR / Pharmacogic be used to reduce the inflammation during the attack of Covid19 . Initially although the Drug was not getting approval from WHO but later on the drug is approved by WHO .

2. Lopinalvir / Biological activity &

F– Rinonavir Combination ( antiviral )– This cormulations of the abbination is used against HIV in the treatment of AIDS can be

used against Coveid noted syntheticinfection crucially .But most efficient anti-viral / non-against Covid19 – Remdesivir & Probably the final solution.This drug is specific to severe acute respiratory syndrome ( SARS-COV-2 ) .

3. Flavipiravir ( antiviral drugs for Covid19 ) –

) –This drug is used against the treatment of Japanese influenza is also used in India under the approval of DGCA , Govt of India , and Glen mark Pharmaceuttps://www.researchgate.net/profile/Jaydip_Datta/questions -icals Ltd . This drug is a cheaper one than Remdesivir itself . It can be also used in diabetic & Hypertension patients of Covid19 .

4. Rimantadine ( Datta J , Shall we beleive that thAmantadine ) – This drug is under trial but found efficient for elderly patient to treat respiratory

syndrome due to Covid19 .

5. Dexamethasone – A a assymetrnon anti-viral cortico-steroid used as life saving medicine ( LSM ) during severe Covid19 infection

. But it is non c characteovid specific and also having other broad spectrum uses .

6 . Interiferon – Beta – Ib – used for stics of Maleria ymptomatic Covid infections in combination with best Lopinavir – Ritonavir to

Remdesivir if necessary.7 .Remdesivir - The most effective antiviral against SARS-COV-2 used in wide spectrum in severe acute respiratory failure .

REF : asbmd.org

The second Cporowtion of the discussion contains vaccine developement .

The vaccine virus ? , May 01 ,

developement incuding trial has already started SII ( Pune ) are under trial of Phase2020-3 trials .

D AstrattZeneca J , Justification of Lopinavir - Ritonavir & Finally Remdesivir ( higher generation of ac- Oxford university , Cansino , Pfizer are trying under trial vaccine . As we are all aware that it is a long way to find out the ethical trial ( clinical efficacy ) universally U.S.S.R has been under claim stage of Sputnik V final phase trial . We the common people are in good hope that the vaccination will get in success to stop such Spike Crown .Without the term immunity vaccination will not be effecrive to irradicate the viral infection .I

Vaccine developement under trial -1. AZD1222-A decision is taken byc the panelovi of expert of AZ Pharma willreview the unexpected of UK pateints -https://health.economictimes.indiatimes.com/tag/unexplained+illness For Immunity booster -new formulanalog ) usedtion based on Zinc Gluconate and naturalVitamin C coming from Acerola Cherry for boosting immunity -To accelerate vaccine workhttps://health.economictimes.indiatimes.com/tag/covid-19+drug.

2. in

Covid19 Vaccine is treatment ? , Motally unpredictedhttps://health.economictimes.indiatimes.com/l.php?url=https%3A%2F%2Fhealth.economictimes.indiatimes.com%2Fnews%2Findustry%2Ftaking-the-good-with-the-bad-how-potentiay l-covid-13 , 20209vaccines-offered-hope-and-disappointment%2F78069594&mailer_id=0&item_id=3919885&dt=2020-09-12&utm_source=Mailer&utm_medium=ET_batch&utm_campaign=ethealth_news_2020-09-12

3. A venture of Serum Institute ofIndiahttps://health.economictimes.

Dindiatimes.com/tag/serum+insttitute+of+india

4.Whether JMask is , Flaan equivalent Vaccine -https://www.webmd.com/lung/news/20200909/couldyour-mask-be-a-kind-of-vaccine-against-covid-19

5. CPT( Convialescent plasma therapiravir - Justification of use againy ) -Not effective to reduce thre mortality of severe Covid-infectionhttps://www.webmd.com/lung/news/20200909/could-your-mask-be-a-kind-of-vaccine-againstcovid-19" Variolation "of SARS-COV-2 -Waiting for a vaccine -10.1056/NEJMp2026913

6.Immunological restponse of Covid19 ? Vaccination -SARS , MERS Epidemic .

7.Article JImmune 21 , 2020 responses in COVID-19 and potential vaccines: Lessons.

Activated Vit-D for better Immunity .

8.Military Growing policy tta Jhrough vaccineresearch in Chinahttps://www.nature.com/articles/d41586-020-02523-x .

9.Chemist ,Martin Broad Spectrum Synthetic ooke has developed an unique test of Covid for student ofIllinois University but the infection of the Spike protein can't be stopped -https://www.npr.org/sections/healthshots/2020/08/15/902616040/can-testing-students-for-coronavirus-twice-a-week-prevent-campusoutbreaks .

10 .Please look back on Gam-COVID-Vac -https://www.raps.org/news-and-articles/newsarticles/2020/3/covid-19-vaccine-tracker

11. The third trials of AZ resumes trial in U.K-https://www.hindustantimes.com/worldnews/suspension-of-astrazeneca-covid-19-vaccine-trials-showed-fallacy-of-approach-rdif-ceo/story-rw09PX3WZQAKo1onyT6WEL.html

12.COVISHIELD trial -https://www.timesnownews.com/health/article/covishield-update-oxfordcovid-19-vaccine-likely-to-be-the-

13 . SPUTNIK- V - This viral Compounds ( Inclaccines has already claimed Post registration clinical trial of SPUTNIK V for 40,000 people in Russia and Belarus has been succesfully administered without any complications -https://clinicaltrials.gov/ct2/show/NCT04437875?term=Gamaleya&draw=2&rank=2 .

14.Social cociousness to be ding covid19 ) - A Short Review ? , eveloped for better lifestyle more immune to us against viral attack or antibody generation . Immunity is surely surely correlated for vaccination or immunological biotechnology of SARS-COV-2 infection . The above discussion links are showing a great effort of a potent Covid -vaccination with appropiate clinical safety and efficiacy trial

REFERENCES :

1.https://www.researchgate.net/profile/Jaydip_Datta/quneestions -

( Datta J , Shall we beleive that the Covid19 has a assymetric characteristics of Maleria and Crown virus ? , May 01 ,

2020 .

2.Datta J , Justification of Lopinavir - Ritonavir & Finally Remdesivir ( higher generation of acyclovir analog ) used in Covid19 treatment ? , May 13 , 2020 .

3.Datta J , Flavipiravir - Justification of use against Covid19 ? June 21 , 2020 .

4.Datta J , Broad Spectrum Synthetic Antiviral Compounds ( Including covid19 ) - A Short Review ? , June ,30 ,2020

5. https://www.researchgate.net/post/Whether_Chemistry_Pharmacy_are_interdisciplinary-acedemics_research-updated_to_pandemic_Covid19 -Jaydip Datta ,32020.

6 .https://www.researchgate.net/post/What_is_fate_of_Clinical_Ethics_in_case_of_Final_trial_of_a_New_Drug - Jaydip Datta ,20 2019 .

7.Covid19 , Covid19 : IMMUNITY AND LIFESTYLE - Datta Jaydip -(https://encyclopedia.pub/item/revision/a69b9fb73d328ace21eb6e2858b29d63)

9 Datta J , researchgate.net ( RG )

9.1)Do We belive that spreading & death of people by Covid 19 is due to severe damage of Environmental Sustainibility ?

( Started April 7 ) .

9.2)How Drugless therapy helps us to Improve our health as well as to prevent Viral attack ?( Started February 28 ) .

9.3 )Shall we beleive that the Covid19 has a asymmetric characteristics of Malaria and Crown virus ? ( Started May 1 ) . What is Malnutrition - Do You agree it is a Global Problem particularly in the Third world countries ? ( Asked December 11,2019 ) .

9.4 )What is GREEN HEALTH ? ( Asked December 1, 2019 ) .

9.5)What is Food adulteration - Is it a Big Problem ? ( Asked November 11 , 2019 ) What is balanced diet - Will You support that it is essential to fight agaist COVID-19 ? ( Asked November 7 , 2019 ) .

9.6)What do you prefer to take ANIMAL or VEGETABLE protein under attack of corona virus ? ( Asked October 28 , 2019 ) . Mental Frustation during LOCKDOWN period of Covid19 is more prone towards infection Share your feelings ? ( Asked December 19 , 2019 ) .

9.7)What is SLEEP ? ( Asked October 9 , 2019 ) Your favourite food as Anti-Oxidant - Let us discuss ? ( Started September 27 , 2019 ) TEA or COFFEE - Which one is good for heath ? ( Started October , 29 , 2019 ).

10.HEALTH & ENVIRONMENT: A SOCIOLOGICAL CONCIOUSNESS ( Preprint ) ,researchgate.net ( RG ) -Datta J . November 2019.

11.BALANCED DIET & ADULTERATION : An Impression ( Experimental Findings ), researchgate.net ( RG )-Datta J, ebruary 2020 .

12. Nature@newsletter.nature.com.

13. newsletter@ethealthworld.com.

14. https://www.researchgate.net/post/Covid19 Vaccination-How far How long - Datta Jaydip .

15. https://www.researchgate.net/post/What is fate of Clinical Ethics in case of Final trial of a New Drug -

Datta Jaydip .

16. https://www.researchgate.net/post/Whether Bio-Technological Research is essential to develope our na-

tion including the threats of Corona Virus-How - Datta Jaydip .

17. https://www.researchgate.net/post/Let us Discuss something about Reproducible research technique in-

cluding COVID 19 - Datta Jaydip .

18. https://www.researchgate.net/post/What is our Knowledge or Updates about Covid19-It s source devel-

opement measurement - Datta Jaydip.

19. Covid19 Vaccine development ( ? ) { News updatate ( Preprint article ) , Datta Jaydip , figshare.con , Sept ,2020

20. .)https://www.researchgate.net/post/What_is_fate_of_Clinical_Ethics_in_case_of_Final_trial_of_a_New_Drug , Jaydip Datta.

Cite as-

JAYDIP DATTA. (2020, November 4). COVID19 DRUG REVIEW DISCUSSIONS (Version Version 1.0). Zenodo. http://doi.org/10.5281/zenodo.4244641