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Demyelination Model Simulating Progressive Multiple Sclerosis
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  • View Times: 54
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  • Update Date: 11 Apr 2023
  • multiple sclerosis
  • tryptophan
  • kynurenine
  • cuprizone
  • demyelination
  • remyelination
  • translational
Video Introduction

This video is adapted from 10.3390/biomedicines11030945

In the video, researchers examined the effects of the Cuprizone toxin on the myelin sheaths in mice, which shows similar histopathological features as progressive multiple sclerosis. Specifically, researchers analyzed the tryptophan metabolites in this mouse model and found that the kynurenine metabolite profile may be a promising biomarker for progressive multiple sclerosis. This discovery could be valuable in developing personalized treatment plans, which can be difficult to formulate due to the influence of immunologic components during flare-ups.

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Tanaka, M.; Polyák, H.; Galla, Z.; Nánási, N.; Cseh, E.K.; Rajda, C.; Veres, G.; Spekker, E.; Szabó, �.; Klivényi, P.; et al. Demyelination Model Simulating Progressive Multiple Sclerosis. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/704 (accessed on 05 December 2025).
Tanaka M, Polyák H, Galla Z, Nánási N, Cseh EK, Rajda C, et al. Demyelination Model Simulating Progressive Multiple Sclerosis. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/704. Accessed December 05, 2025.
Tanaka, Masaru, Helga Polyák, Zsolt Galla, Nikolett Nánási, Edina Katalin Cseh, Cecília Rajda, Gábor Veres, Eleonóra Spekker, Ágnes Szabó, Péter Klivényi, et al. "Demyelination Model Simulating Progressive Multiple Sclerosis" Encyclopedia, https://encyclopedia.pub/video/video_detail/704 (accessed December 05, 2025).
Tanaka, M., Polyák, H., Galla, Z., Nánási, N., Cseh, E.K., Rajda, C., Veres, G., Spekker, E., Szabó, �., Klivényi, P., & Vécsei, L. (2023, April 11). Demyelination Model Simulating Progressive Multiple Sclerosis. In Encyclopedia. https://encyclopedia.pub/video/video_detail/704
Tanaka, Masaru, et al. "Demyelination Model Simulating Progressive Multiple Sclerosis." Encyclopedia. Web. 11 April, 2023.
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