Infectious laryngotracheitis is a very important respiratory disease of poultry. It causes inflammation of the upper respiratory tract and mucous membranes of the eye. A large number of birds in the flock can be infected and mortality is variable. It is a viral disease, transmitted horizontally in a flock and causes great economic losses. In this study, we presented data on the occurrence of the disease after 20 years in unvaccinated flocks in the Vojvodina region and proposed a strategy for the prevention and control of this disease. Infected flocks had a severe clinical symptoms with a decrease in egg production and increased mortality. Clinical symptoms lasted from two to four weeks. We prevented the spread of the virus in one flock applying emergency vaccination with live vaccine. It can be concluded that the disease can easily spread between unvaccinated flocks. The most important thing is to improve biosecurity measures on the farm and implement vaccination in endemic areas.