Summary

HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Cryptogenic Organizing Pneumonia
Cryptogenic organizing pneumonia (COP), formerly known as bronchiolitis obliterans organizing pneumonia (BOOP), is an inflammation of the bronchioles (bronchiolitis) and surrounding tissue in the lungs. It is a form of idiopathic interstitial pneumonia. It is often a complication of an existing chronic inflammatory disease such as rheumatoid arthritis, dermatomyositis, or it can be a side effect of certain medications such as amiodarone. COP was first described by Gary Epler in 1985. The clinical features and radiological imaging resemble infectious pneumonia. However, diagnosis is suspected after there is no response to multiple antibiotics, and blood and sputum cultures are negative for organisms.
  • 1.3K
  • 25 Oct 2022
Topic Review
Externalizing Disorders
Externalizing disorders (or externalising disorders) are mental disorders characterized by externalizing behaviors, maladaptive behaviors directed toward an individual's environment, which cause impairment or interference in life functioning. In contrast to individuals with internalizing disorders who internalize (keep inside) their maladaptive emotions and cognitions, such feelings and thoughts are externalized (manifested outside) in behavior in individuals with externalizing disorders. Externalizing disorders are often specifically referred to as disruptive behavior disorders (attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder) or conduct problems which occur in childhood. Externalizing disorders, however, are also manifested in adulthood. For example, alcohol- and substance-related disorders and antisocial personality disorder are adult externalizing disorders. Externalizing psychopathology is associated with antisocial behavior, which is different from and often confused for asociality.
  • 3.2K
  • 25 Oct 2022
Topic Review
Zomia (Region)
Zomia is a geographical term coined in 2002 by historian Willem van Schendel of the University of Amsterdam to refer to the huge mass of mainland Southeast Asia that has historically been beyond the control of governments based in the population centers of the lowlands.
  • 7.7K
  • 25 Oct 2022
Topic Review
List of Notable Security Hacking Incidents
The timeline of computer security hacker history covers important and noteworthy events in the history of security hacking and cracking.
  • 3.1K
  • 25 Oct 2022
Topic Review
Project Medishare
Project Medishare is a 501(c)(3), non-profit organization registered in the State of Florida. It was founded by Dr. Barth Green and Arthur Fournier from the University of Miami School of Medicine. The organization was created in 1994 to improve healthcare in Haiti. Since then, it has been committed to help its Haitian partners by establishing and funding sustainable programs, providing technology and equipment to hospitals, clinics, and other affiliated programs and training of Haitian physicians, nurses, and allied health professionals. Project Medishare’s focus program include Community Health, Maternal Health, Child Health and Nutrition, and Medical Training and Education. The geographic areas served by the organization include Port-au-Prince and the Central Plateau in Haiti. The organization provides direct beneficiaries for more than 80,000 people every year.
  • 1.1K
  • 25 Oct 2022
Topic Review
Saving the Appearances: A Study in Idolatry
Saving the Appearances: A Study in Idolatry, a book by British philosopher Owen Barfield, is concerned with physics, the evolution of consciousness, pre-history, ancient Greece, ancient Israel, the medieval period, the scientific revolution, Christianity, Romanticism, and much else. The book was Barfield's favorite of those he authored, and the one that he most wanted to continue to be read. It was first published in England in 1957, and it was first issued in paperback in the United States in 1965. According to Barfield, the book enjoyed a far greater reception by the public in the United States, where Barfield often accepted invitations to lecture, than it did in England. The book explores approximately three thousand years of history — particularly the history of human consciousness in relation to that which precedes or underlies the world of perception or phenomena. Given the vast field considered by the book, it is concise and brief, about two hundred pages. Barfield describes the growth of human consciousness as an interaction with nature, leading the reader to a fresh understanding of man's history, circumstances, and destiny. Saving the Appearances has in common with some thoughts of Teilhard de Chardin the understanding of idols as appearances having nothing within. "[A] representation, which is collectively mistaken for an ultimate – ought not to be called a representation. It is an idol. Thus the phenomena themselves are idols, when they are imagined as enjoying that independence of human perception which can in fact only pertain to the unrepresented."
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  • 25 Oct 2022
Topic Review
Mental Health Awareness Month
Mental Health Awareness Month (also referred to as "Mental Health Month") has been observed in May in the United States since 1949, reaching millions of people in the United States through the media, local events, and screenings. Mental Health Awareness Month was started in the United States in 1949 by the Mental Health America organization (then known as the National Association for Mental Health). Each year in mid-March Mental Health America releases a toolkit of materials to guide preparation for outreach activities during Mental Health Awareness Month. During the month of May, Mental Health America, its affiliates, and other organizations interested in mental health conduct a number of activities which are based on a different theme each year. 
  • 676
  • 25 Oct 2022
Topic Review
IBM Mainframe Utility Programs
IBM mainframe utility programs are utility software supplied with IBM mainframe operating systems such as MVS and zOS to carry out various tasks associated with maintenance of the computer system or datasets. The following list describes utilities distributed with OS/360 and successors. No VSE or VM utilities are included.
  • 6.7K
  • 26 Oct 2022
Topic Review
Valley Network
Valley networks are branching networks of valleys on Mars that superficially resemble terrestrial river drainage basins. They are found mainly incised into the terrain of the martian southern highlands, and are typically - though not always - of Noachian age (approximately four billion years old). The individual valleys are typically less than 5 kilometers wide, though they may extend for up to hundreds or even thousands of kilometers across the martian surface. The form, distribution, and implied evolution of the valley networks are of great importance for what they may tell us about the history of liquid water on the martian surface, and hence Mars' climate history. Some authors have argued that the properties of the networks demand that a hydrological cycle must have been active on ancient Mars, though this remains contentious. Objections chiefly arise from repeated results from models of martian paleoclimate suggesting high enough temperatures and pressures to sustain liquid water on the surface have not ever been possible on Mars. The advent of very high resolution images of the surface from the HiRISE, THEMIS and Context (CTX) satellite cameras as well as the Mars Orbital Laser Altimeter (MOLA) digital terrain models have drastically improved our understanding of the networks in the last decade.
  • 658
  • 25 Oct 2022
Topic Review
Tumor Suppressor
A tumor suppressor gene, or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or reduction in its function; in combination with other genetic mutations this could allow the cell to grow abnormally. The loss of function for these genes may be even more significant in the development of human cancers, compared to the activation of oncogenes. Tumor suppressor genes can be grouped into the following categories caretaker genes, gatekeeper genes, and more recently landscaper genes. Caretaker genes ensure stability of the genome via DNA repair and subsequently when mutated allow mutations to accumulate. Meanwhile gatekeeper genes directly regulate cell growth by either inhibiting cell cycle progression or inducing apoptosis. Lastly landscaper genes regulate growth by contributing to the surrounding environment, when mutated can cause an environment that promotes unregulated proliferation. The classification schemes are evolving as medical advances are being made from fields including molecular biology, genetics, and epigenetics.
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  • 25 Oct 2022
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