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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Transgender Hormone Therapy (Female-to-Male)
Transgender hormone therapy of the masculinizing type, also known as transmasculine hormone therapy, or female-to-male (or FTM) hormone therapy, is a form of hormone therapy and gender affirming therapy which is used to change the secondary sexual characteristics of transgender people from feminine or androgynous to masculine. It is a type of transgender hormone therapy (another being male-to-female), and is predominantly used to treat transgender men and other transmasculine individuals. Some intersex people also receive this form of therapy, either starting in childhood to confirm the assigned sex or later if the assignment proves to be incorrect. The purpose of this form of therapy is to cause the development of the secondary sex characteristics of the desired sex, such as voice deepening and a masculine pattern of hair, fat, and muscle distribution. It cannot undo many of the changes produced by naturally occurring puberty, which may necessitate surgery and other treatments to reverse. The medications used for FTM therapy include, mainly, androgens (namely testosterone) and GnRH analogues. While the therapy cannot undo the effects of a person's first puberty, developing secondary sex characteristics associated with a different sex can relieve some or all of the distress and discomfort associated with gender dysphoria, and can help the person to "pass" or be seen as the gender they identify with. Introducing exogenous hormones into the body impacts it at every level and many patients report changes in energy levels, mood, appetite, etc. The goal of the therapy, and indeed all somatic treatments, is to provide patients with a more satisfying body that is more congruent with their gender identity.
  • 1.9K
  • 26 Oct 2022
Topic Review
Social Value Orientations
In social psychology, social value orientation (SVO) is a person's preference about how to allocate resources (e.g. money) between the self and another person. SVO corresponds to how much weight a person attaches to the welfare of others in relation to the own. Since people are assumed to vary in the weight they attach to other peoples' outcomes in relation to their own, SVO is an individual difference variable. The general concept underlying SVO has become widely studied in a variety of different scientific disciplines, such as economics, sociology, and biology under a multitude of different names (e.g. social preferences, other-regarding preferences, welfare tradeoff ratios, social motives, etc.).
  • 1.6K
  • 25 Oct 2022
Topic Review
WebRTC
WebRTC (Web Real-Time Communication) is a free and open-source project providing web browsers and mobile applications with real-time communication (RTC) via application programming interfaces (APIs). It allows audio and video communication to work inside web pages by allowing direct peer-to-peer communication, eliminating the need to install plugins or download native apps. Supported by Apple, Google, Microsoft, Mozilla, and Opera, WebRTC specifications have been published by the World Wide Web Consortium (W3C) and the Internet Engineering Task Force (IETF). According to the webrtc.org website, the purpose of the project is to "enable rich, high-quality RTC applications to be developed for the browser, mobile platforms, and IoT devices, and allow them all to communicate via a common set of protocols".
  • 3.1K
  • 25 Oct 2022
Topic Review
Impulsivity
In psychology, impulsivity (or impulsiveness) is a tendency to act on a whim, displaying behavior characterized by little or no forethought, reflection, or consideration of the consequences. Impulsive actions are typically "poorly conceived, prematurely expressed, unduly risky, or inappropriate to the situation that often result in undesirable consequences," which imperil long-term goals and strategies for success. Impulsivity can be classified as a multifactorial construct. A functional variety of impulsivity has also been suggested, which involves action without much forethought in appropriate situations that can and does result in desirable consequences. "When such actions have positive outcomes, they tend not to be seen as signs of impulsivity, but as indicators of boldness, quickness, spontaneity, courageousness, or unconventionality" Thus, the construct of impulsivity includes at least two independent components: first, acting without an appropriate amount of deliberation, which may or may not be functional; and second, choosing short-term gains over long-term ones. Impulsivity is both a facet of personality and a major component of various disorders, including ADHD, substance use disorders, bipolar disorder, antisocial personality disorder, and borderline personality disorder. Abnormal patterns of impulsivity have also been noted instances of acquired brain injury and neurodegenerative diseases. Neurobiological findings suggest that there are specific brain regions involved in impulsive behavior, although different brain networks may contribute to different manifestations of impulsivity, and that genetics may play a role. Many actions contain both impulsive and compulsive features, but impulsivity and compulsivity are functionally distinct. Impulsivity and compulsivity are interrelated in that each exhibits a tendency to act prematurely or without considered thought and often include negative outcomes. Compulsivity may be on a continuum with compulsivity on one end and impulsivity on the other, but research has been contradictory on this point. Compulsivity occurs in response to a perceived risk or threat, impulsivity occurs in response to a perceived immediate gain or benefit, and, whereas compulsivity involves repetitive actions, impulsivity involves unplanned reactions. Impulsivity is a common feature of the conditions of gambling and alcohol addiction. Research has shown that individuals with either of these addictions discount delayed money at higher rates than those without, and that the presence of gambling and alcohol abuse lead to additive effects on discounting.
  • 1.9K
  • 25 Oct 2022
Topic Review
Climate Bond
Climate bonds (also known as green bonds) are fixed-income financial instruments (bonds) which are used to fund projects that have positive environmental and/or climate benefits. They follow the Green Bond Principles stated by the International Capital Market Association (ICMA), and the proceeds from the issuance of which are to be used for the pre-specified types of projects. They differ from sustainability bonds in that the latter also needs to have a positive social outcome, besides simply having a positive impact on the environment.
  • 1.2K
  • 25 Oct 2022
Topic Review
Analytica
Analytica is a visual software developed by Lumina Decision Systems for creating, analyzing and communicating quantitative decision models. It combines hierarchical influence diagrams for visual creation and view of models, intelligent arrays for working with multidimensional data, Monte Carlo simulation for analyzing risk and uncertainty, and optimization, including linear and nonlinear programming. Its design, especially its influence diagrams and treatment of uncertainty, is based on ideas from the field of decision analysis. As a computer language, it combines a declarative (non-procedural) structure for referential transparency, array abstraction, and automatic dependency maintenance for efficient sequencing of computation.
  • 2.1K
  • 25 Oct 2022
Topic Review
Unique Games Conjecture
In computational complexity theory, the unique games conjecture (often referred to as UGC) is a conjecture made by Subhash Khot in 2002. The conjecture postulates that the problem of determining the approximate value of a certain type of game, known as a unique game, has NP-hard computational complexity. It has broad applications in the theory of hardness of approximation. If the unique games conjecture is true and P ≠ NP, then for many important problems it is not only impossible to get an exact solution in polynomial time (as postulated by the P versus NP problem), but also impossible to get a good polynomial-time approximation. The problems for which such an inapproximability result would hold include constraint satisfaction problems, which crop up in a wide variety of disciplines. The conjecture is unusual in that the academic world seems about evenly divided on whether it is true or not.
  • 1.6K
  • 26 Oct 2022
Topic Review
Fedora (Operating System)
Fedora is a Linux distribution developed by the community-supported Fedora Project which is sponsored primarily by Red Hat, a subsidiary of IBM, with additional support from other companies. Fedora contains software distributed under various free and open-source licenses and aims to be on the leading edge of free technologies. Fedora is the upstream source of the commercial Red Hat Enterprise Linux distribution and for CentOS. Fedora is a fork of Red Hat Linux since RHL was discontinued in 2003. Since the release of Fedora 30, five different editions are currently available: Workstation, focused on the personal computer, Server for servers, CoreOS, focused on cloud computing, Silverblue, focused on an immutable desktop specialized to container-based workflows and IoT, focused on IoT devices. (As of February 2016), Fedora has an estimated 1.2 million users, including Linus Torvalds ((As of May 2020)), creator of the Linux kernel.
  • 6.6K
  • 27 Oct 2022
Topic Review
Ketosis
Ketosis is a metabolic state characterized by elevated levels of ketone bodies in the blood or urine. Physiological ketosis is a normal response to low glucose availability, such as low-carbohydrate diets or fasting, that provides an additional energy source for the brain in the form of ketones. In physiological ketosis, ketones in the blood are elevated above baseline levels, but the body's acid–base homeostasis is maintained. This contrasts with ketoacidosis, an uncontrolled production of ketones that occurs in pathologic states and causes a metabolic acidosis, which is a medical emergency. Ketoacidosis is most commonly the result of complete insulin deficiency in type 1 diabetes or late-stage type 2 diabetes. Ketone levels can be measured in blood, urine or breath and are generally between 0.5 and 3.0 millimolar (mM) in physiological ketosis, while ketoacidosis may cause blood concentrations greater than 10 mM. Trace levels of ketones are always present in the blood and increase when blood glucose reserves are low and the liver shifts from primarily metabolizing carbohydrates to metabolizing fatty acids. This occurs during states of increased fatty acid oxidation such as fasting, starvation, carbohydrate restriction, or prolonged exercise. When the liver rapidly metabolizes fatty acids into acetyl-CoA, some acetyl-CoA molecules can then be converted into ketone bodies: acetoacetate, beta-hydroxybutyrate, and acetone. These ketone bodies can function as an energy source as well as signalling molecules. The liver itself cannot utilize these molecules for energy, so the ketone bodies are released into the blood for use by peripheral tissues including the brain. When ketosis is induced by carbohydrate restriction, it is sometimes referred to as nutritional ketosis. A low-carbohydrate, moderate protein diet that can lead to ketosis is called a ketogenic diet. Ketosis is well-established as a treatment for epilepsy and is also effective in treating type 2 diabetes.
  • 2.4K
  • 25 Oct 2022
Topic Review
Earth Strike
Earth Strike is an international grassroots movement that called for a global general strike for climate action. Their aim was a global general strike lasting from 20 until 27 September 2019. The movement has had public support from organizations including Extinction Rebellion and Fridays for Future, as well as public figures including Noam Chomsky. The Earth Strikes were part of the worldwide September 2019 climate strikes, which gathered millions of protesters. An estimated 6 million people participated in strikes worldwide from 20–27 September. Youth environmental activist Greta Thunberg spoke in New York on the 20 September strike and Montreal on the 27 September strike.
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  • 25 Oct 2022
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