Summary

HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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LAG3
Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right.
  • 1.4K
  • 02 Nov 2022
Topic Review
KIVA
KIVA is a family of Fortran-based Computational Fluid Dynamics software developed by Los Alamos National Laboratory (LANL). The software predicts complex fuel and air flows as well as ignition, combustion, and pollutant-formation processes in engines. The KIVA models have been used to understand combustion chemistry processes, such as auto-ignition of fuels, and to optimize diesel engines for high efficiency and low emissions. General Motors has used KIVA in the development of direct-injection, stratified charge gasoline engines as well as the fast burn, homogeneous-charge gasoline engine. Cummins reduced development time and cost by 10%–15% using KIVA to develop its high-efficiency 2007 ISB 6.7-L diesel engine that was able to meet 2010 emission standards in 2007. At the same time, the company realized a more robust design and improved fuel economy while meeting all environmental and customer constraints.
  • 1.4K
  • 02 Nov 2022
Topic Review
List of Amphibians of South Africa
This list of amphibians of South Africa contains species that form a part of the class Amphibia (phylum Chordata) fauna of South Africa. The list follows the South African National Bioinformatics Institute listing. Where common names are given, they are not the only common names in use for the species.
  • 1.6K
  • 03 Nov 2022
Topic Review
Atom (Web Standard)
The name Atom applies to a pair of related Web standards. The Atom Syndication Format is an XML language used for web feeds, while the Atom Publishing Protocol (AtomPub or APP) is a simple HTTP-based protocol for creating and updating web resources. Web feeds allow software programs to check for updates published on a website. To provide a web feed, the site owner may use specialized software (such as a content management system) that publishes a list (or "feed") of recent articles or content in a standardized, machine-readable format. The feed can then be downloaded by programs that use it, like websites that syndicate content from the feed, or by feed reader programs that allow internet users to subscribe to feeds and view their content. A feed contains entries, which may be headlines, full-text articles, excerpts, summaries or links to content on a website along with various metadata. The Atom format was developed as an alternative to RSS. Ben Trott, an advocate of the new format that became Atom, believed that RSS had limitations and flaws—such as lack of on-going innovation and its necessity to remain backward compatible—and that there were advantages to a fresh design. Proponents of the new format formed the IETF Atom Publishing Format and Protocol Workgroup. The Atom Syndication Format was published as an IETF proposed standard in RFC 4287 (December 2005), and the Atom Publishing Protocol was published as RFC 5023 (October 2007).
  • 943
  • 02 Nov 2022
Topic Review
List of Cranesbill Species
The genus Geranium contains more than 420 plant species, which are also known as cranesbill or hardy geranium (to distinguish them from Pelargonium species).
  • 1.2K
  • 02 Nov 2022
Topic Review
Lagosuchus
Lagosuchus is an extinct genus of avemetatarsalian archosaur from the Late Triassic of Argentina . The type species of Lagosuchus, Lagosuchus talampayensis, is based on a small partial skeleton recovered from the early Carnian-age Chañares Formation. The holotype skeleton of L. talampayensis is fairly fragmentary, but it does possess some traits suggesting that Lagosuchus was a probable dinosauriform, closely related to dinosaurs. A second potential species of Lagosuchus, L. lilloensis, is based on an assortment of slightly larger and more well-preserved fossils. These larger specimens have been considered much more diagnostic and informative than the original small L. talampayensis skeleton. As a result, some paleontologists have placed the larger specimens into a new genus, Marasuchus. Marasuchus is generally considered one of the more complete early dinosauriforms, useful for estimating ancestral traits for the origin of dinosaurs. This would also render Lagosuchus a nomen dubium, simply a name referring to a fossil which is too fragmentary to have a formal genus. However, other paleontologists support the argument that Lagosuchus is a valid genus, and that Marasuchus is a junior synonym of it.
  • 1.3K
  • 02 Nov 2022
Topic Review
List of UN Numbers 3301 to 3400
The UN numbers from UN3301 to UN3400 as assigned by the United Nations Committee of Experts on the Transport of Dangerous Goods.
  • 706
  • 02 Nov 2022
Topic Review
Francs-Tireurs
Francs-tireurs (pronounced [fʁɑ̃.ti.ʁœʁ], French for "free shooters") were irregular military formations deployed by France during the early stages of the Franco-Prussian War (1870–71). The term was revived and used by partisans to name two major French Resistance movements set up to fight against the Germans during World War II. The term is sometimes used to refer more generally to guerrilla fighters who operate outside the laws of war.
  • 1.8K
  • 02 Nov 2022
Topic Review
Bacteroidetes
The phylum "Bacteroidetes" is composed of three large classes of Gram-negative, nonsporeforming, anaerobic or aerobic, and rod-shaped bacteria that are widely distributed in the environment, including in soil, sediments, and sea water, as well as in the guts and on the skin of animals. Although some Bacteroides spp. can be opportunistic pathogens, many "Bacteroidetes" are symbiotic species highly adjusted to the gastrointestinal tract. Bacteroides are highly abundant in intestines, reaching up to 1011 cells g−1 of intestinal material. They perform metabolic conversions that are essential for the host, such as degradation of proteins or complex sugar polymers. "Bacteroidetes" colonize the gastrointestinal tract already in infants, as non-digestible oligosaccharides in mother milk support the growth of both Bacteroides and Bifidobacterium spp. Bacteroides spp. are selectively recognized by the immune system of the host through specific interactions.
  • 3.3K
  • 21 Jul 2025
Topic Review
Enchanted Rock
Enchanted Rock (16710 Ranch Rd 965, Fredericksburg TX) is a pink granite mountain located in the Llano Uplift approximately 17 miles (27 km) north of Fredericksburg, Texas and 24 miles (39 km) south of Llano, Texas, United States. Enchanted Rock State Natural Area, which includes Enchanted Rock and surrounding land, spans the border between Gillespie County and Llano County, south of the Llano River. Enchanted Rock covers approximately 640 acres (260 ha) and rises approximately 425 feet (130 m) above the surrounding terrain to elevation of 1,825 feet (556 m) above sea level. It is the largest pink granite monadnock in the United States. Enchanted Rock State Natural Area, a part of the Texas state park system, includes 1,644 acres (665 ha). Designated a Recorded Texas Historic Landmark in 1936. In 1971, Enchanted Rock was designated as a National Natural Landmark by the National Park Service. Enchanted Rock was rated in 2017 as the best campsite in Texas in a 50-state survey conducted by Msn.com.
  • 1.5K
  • 02 Nov 2022
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