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HandWiki. LAG3. Encyclopedia. Available online: https://encyclopedia.pub/entry/32519 (accessed on 25 September 2026).
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LAG3
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The content is sourced from: https://handwiki.org/wiki/Biology:LAG3

Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right.

cell surface molecule leucocyte lymphocyte-activation

References

  1. "Entrez Gene: LAG3 lymphocyte-activation gene 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3902. 
  2. "LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems". The Journal of Clinical Investigation 117 (11): 3383–92. Nov 2007. doi:10.1172/JCI31184. PMID 17932562.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2000807
  3. "LAG-3, a novel lymphocyte activation gene closely related to CD4". The Journal of Experimental Medicine 171 (5): 1393–405. May 1990. doi:10.1084/jem.171.5.1393. PMID 1692078.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2187904
  4. "Molecular cloning and expression analysis of pig lymphocyte activation gene-3 (LAG-3; CD223)". Veterinary Immunology and Immunopathology 133 (1): 72–9. Jan 2010. doi:10.1016/j.vetimm.2009.07.001. PMID 19631993.  https://dx.doi.org/10.1016%2Fj.vetimm.2009.07.001
  5. "Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand". Immunogenetics 39 (3): 213–7. January 1, 1994. doi:10.1007/bf00241263. PMID 7506235.  https://dx.doi.org/10.1007%2Fbf00241263
  6. "Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells". European Journal of Immunology 35 (7): 2081–8. Jul 2005. doi:10.1002/eji.200526090. PMID 15971272.  https://dx.doi.org/10.1002%2Feji.200526090
  7. "LAG-3 regulates plasmacytoid dendritic cell homeostasis". Journal of Immunology 182 (4): 1885–91. Feb 2009. doi:10.4049/jimmunol.0800185. PMID 19201841.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2675170
  8. "CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins". European Journal of Immunology 25 (9): 2718–21. Sep 1995. doi:10.1002/eji.1830250949. PMID 7589152.  https://dx.doi.org/10.1002%2Feji.1830250949
  9. Huard B, Tournier M, Hercend T, Triebel F, and Faure F. Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes. European journal of immunology. 1994;24(12):3216-21.
  10. "The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells". European Journal of Immunology 33 (4): 970–9. Apr 2003. doi:10.1002/eji.200323382. PMID 12672063.  https://dx.doi.org/10.1002%2Feji.200323382
  11. "Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo". Journal of Immunology 172 (9): 5450–5. May 2004. doi:10.4049/jimmunol.172.9.5450. PMID 15100286.  https://dx.doi.org/10.4049%2Fjimmunol.172.9.5450
  12. "Role of LAG-3 in regulatory T cells". Immunity 21 (4): 503–13. Oct 2004. doi:10.1016/j.immuni.2004.08.010. PMID 15485628.  https://dx.doi.org/10.1016%2Fj.immuni.2004.08.010
  13. "Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3". Cell 176 (1–2): 334–47. Jan 2019. doi:10.1016/j.cell.2018.11.010. PMID 30580966.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6365968
  14. "Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection". Nature Immunology 10 (1): 29–37. Jan 2009. doi:10.1038/ni.1679. PMID 19043418.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2605166
  15. "Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223)". Journal of Immunology 168 (8): 3874–80. Apr 2002. doi:10.4049/jimmunol.168.8.3874. PMID 11937541.  https://dx.doi.org/10.4049%2Fjimmunol.168.8.3874
  16. "Oncology Pipeline at Immutep | Immunotherapy Treatment". https://www.immutep.com/pipeline/clinical-pipeline.html#imp. 
  17. Avice M; Sarfati M; Triebel F; Delespesse G; Demeure CE. (March 1, 1999). "Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells.". J. Immunol. 162 (5): 2748–53. PMID 10072520.  http://www.ncbi.nlm.nih.gov/pubmed/10072520
  18. Syn, Nicholas L; Teng, Michele W L; Mok, Tony S K; Soo, Ross A (December 2017). "De-novo and acquired resistance to immune checkpoint targeting" (in en). The Lancet Oncology 18 (12): e731–e741. doi:10.1016/s1470-2045(17)30607-1. PMID 29208439.  https://dx.doi.org/10.1016%2Fs1470-2045%2817%2930607-1
  19. Clinical trial number NCT03704077 for "An Investigational Immuno-therapy Study of Relatlimab Plus Nivolumab Compared to Various Standard-of-Care Therapies in Previously Treated Participants With Recurrent, Advanced or Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma" at ClinicalTrials.gov https://www.clinicaltrials.gov/show/NCT03704077
  20. "Tesaro's Immuno-Oncology Platform". http://www.tesarobio.com/immuno-oncology_portfolio. 
  21. "Technology Platforms". Immutep LAG-3. http://www.immutep.org/ProductDevelopment/TechnologyPlatform. 
  22. A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Subjects and Patients With Plaque Psoriasis https://www.clinicaltrials.gov/ct2/show/NCT02195349
  23. "LAG-3, a novel lymphocyte activation gene closely related to CD4". The Journal of Experimental Medicine 171 (5): 1393–405. May 1990. doi:10.1084/jem.171.5.1393. PMID 1692078.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2187904
  24. "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens". The Journal of Experimental Medicine 176 (2): 327–37. Aug 1992. doi:10.1084/jem.176.2.327. PMID 1380059.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2119326
  25. "LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice". International Immunology 8 (5): 725–9. May 1996. doi:10.1093/intimm/8.5.725. PMID 8671660.  https://dx.doi.org/10.1093%2Fintimm%2F8.5.725
  26. "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein". Proceedings of the National Academy of Sciences of the United States of America 94 (11): 5744–9. May 1997. doi:10.1073/pnas.94.11.5744. PMID 9159144. Bibcode: 1997PNAS...94.5744H.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20850
  27. "Independent modes of natural killing distinguished in mice lacking Lag3". Science 272 (5260): 405–8. Apr 1996. doi:10.1126/science.272.5260.405. PMID 8602528. Bibcode: 1996Sci...272..405M.  https://dx.doi.org/10.1126%2Fscience.272.5260.405
  28. "LAG-3 does not define a specific mode of natural killing in human". Immunology Letters 61 (2–3): 109–12. Apr 1998. doi:10.1016/s0165-2478(97)00170-3. PMID 9657262.  https://dx.doi.org/10.1016%2Fs0165-2478%2897%2900170-3
  29. "Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production". FASEB Journal 10 (7): 769–76. May 1996. doi:10.1096/fasebj.10.7.8635694. PMID 8635694.  https://dx.doi.org/10.1096%2Ffasebj.10.7.8635694
  30. "Opposite role for interleukin-4 and interferon-gamma on CD30 and lymphocyte activation gene-3 (LAG-3) expression by activated naive T cells". European Journal of Immunology 27 (9): 2239–44. Sep 1997. doi:10.1002/eji.1830270918. PMID 9341765.  https://dx.doi.org/10.1002%2Feji.1830270918
  31. "Lymphocyte activation gene-3 (LAG-3) expression and IFN-gamma production are variably coregulated in different human T lymphocyte subpopulations". Journal of Immunology 161 (1): 489–93. Jul 1998. PMID 9647260.  http://www.ncbi.nlm.nih.gov/pubmed/9647260
  32. "Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II". Immunogenetics 48 (2): 116–24. Jul 1998. doi:10.1007/s002510050411. PMID 9634475.  https://dx.doi.org/10.1007%2Fs002510050411
  33. "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling". Journal of Immunology 161 (8): 4058–65. Oct 1998. PMID 9780176.  http://www.ncbi.nlm.nih.gov/pubmed/9780176
  34. "The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes". International Immunology 11 (11): 1745–52. Nov 1999. doi:10.1093/intimm/11.11.1745. PMID 10545478.  https://dx.doi.org/10.1093%2Fintimm%2F11.11.1745
  35. 3.0.CO;2-E. PMID 10601994.  https://dx.doi.org/10.1002%2F%28SICI%291521-4141%28199912%2929%3A12%3C3867%3A%3AAID-IMMU3867%3E3.0.CO%3B2-E" id="ref_35">"Lymphocyte activation gene-3 induces tumor regression and antitumor immune responses". European Journal of Immunology 29 (12): 3867–76. Dec 1999. doi:10.1002/(SICI)1521-4141(199912)29:12<3867::AID-IMMU3867>3.0.CO;2-E. PMID 10601994.  https://dx.doi.org/10.1002%2F%28SICI%291521-4141%28199912%2929%3A12%3C3867%3A%3AAID-IMMU3867%3E3.0.CO%3B2-E
  36. 3.0.CO;2-2. PMID 11592063.  https://dx.doi.org/10.1002%2F1521-4141%282001010%2931%3A10%3C2885%3A%3AAID-IMMU2885%3E3.0.CO%3B2-2" id="ref_36">"LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway". European Journal of Immunology 31 (10): 2885–91. Oct 2001. doi:10.1002/1521-4141(2001010)31:10<2885::AID-IMMU2885>3.0.CO;2-2. PMID 11592063.  https://dx.doi.org/10.1002%2F1521-4141%282001010%2931%3A10%3C2885%3A%3AAID-IMMU2885%3E3.0.CO%3B2-2
  37. "T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts". European Journal of Cancer 37 (13): 1709–18. Sep 2001. doi:10.1016/s0959-8049(01)00184-8. PMID 11527700.  https://dx.doi.org/10.1016%2Fs0959-8049%2801%2900184-8
  38. 3.0.CO;2-A. PMID 12209638.  https://dx.doi.org/10.1002%2F1521-4141%28200208%2932%3A8%3C2255%3A%3AAID-IMMU2255%3E3.0.CO%3B2-A" id="ref_38">"Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3)". European Journal of Immunology 32 (8): 2255–63. Aug 2002. doi:10.1002/1521-4141(200208)32:8<2255::AID-IMMU2255>3.0.CO;2-A. PMID 12209638.  https://dx.doi.org/10.1002%2F1521-4141%28200208%2932%3A8%3C2255%3A%3AAID-IMMU2255%3E3.0.CO%3B2-A
  39. "Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3". Journal of Immunology 169 (10): 5392–5. Nov 2002. doi:10.4049/jimmunol.169.10.5392. PMID 12421911.  https://dx.doi.org/10.4049%2Fjimmunol.169.10.5392
  40. "MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223)". Blood 102 (6): 2130–7. Sep 2003. doi:10.1182/blood-2003-01-0273. PMID 12775570.  https://dx.doi.org/10.1182%2Fblood-2003-01-0273
  41. "Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223)". Journal of Immunology 173 (11): 6806–12. Dec 2004. doi:10.4049/jimmunol.173.11.6806. PMID 15557174.  https://dx.doi.org/10.4049%2Fjimmunol.173.11.6806
  42. "Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway". The Journal of Pathology 205 (1): 82–91. Jan 2005. doi:10.1002/path.1679. PMID 15586367.  https://dx.doi.org/10.1002%2Fpath.1679
  43. "Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis". Genes and Immunity 6 (2): 145–52. Mar 2005. doi:10.1038/sj.gene.6364171. PMID 15674389.  https://dx.doi.org/10.1038%2Fsj.gene.6364171
  44. "Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations". Journal of Neuroimmunology 180 (1–2): 193–8. Nov 2006. doi:10.1016/j.jneuroim.2006.08.009. PMID 17020785.  https://dx.doi.org/10.1016%2Fj.jneuroim.2006.08.009
  45. "The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells". Immunology 115 (2): 170–8. Jun 2005. doi:10.1111/j.1365-2567.2005.02145.x. PMID 15885122.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1782137
  46. "Soluble CD30 and lymphocyte activation gene-3 (CD223), as potential serological markers of T helper-type cytokine response induced by acellular pertussis vaccine". International Journal of Immunopathology and Pharmacology 19 (1): 97–104. January 1, 2006. doi:10.1177/205873920601900109. PMID 16569347.  https://dx.doi.org/10.1177%2F205873920601900109
  47. "Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells". Journal of Immunology 178 (7): 4184–93. Apr 2007. doi:10.4049/jimmunol.178.7.4184. PMID 17371975.  https://dx.doi.org/10.4049%2Fjimmunol.178.7.4184
  48. "CD4+CD25+Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie 245 (10): 1549–57. Oct 2007. doi:10.1007/s00417-007-0591-8. PMID 17541623. http://library.wur.nl/WebQuery/wurpubs/369746. 
  49. "LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems". The Journal of Clinical Investigation 117 (11): 3383–92. Nov 2007. doi:10.1172/JCI31184. PMID 17932562.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2000807
  50. "CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2". Proceedings of the National Academy of Sciences of the United States of America 106 (33): 13974–9. Aug 2009. doi:10.1073/pnas.0906872106. PMID 19666526. Bibcode: 2009PNAS..10613974O.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2729005
  51. "On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection". International Immunology 22 (1): 13–23. Jan 2010. doi:10.1093/intimm/dxp107. PMID 19880580.  https://dx.doi.org/10.1093%2Fintimm%2Fdxp107
  52. "Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer". Proceedings of the National Academy of Sciences of the United States of America 107 (17): 7875–80. Apr 2010. doi:10.1073/pnas.1003345107. PMID 20385810. Bibcode: 2010PNAS..107.7875M.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2867907
  53. "Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4". European Journal of Immunology 40 (6): 1768–77. Jun 2010. doi:10.1002/eji.200939874. PMID 20391435.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2987677
  54. "LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites". Journal of Immunology 184 (11): 6545–51. Jun 2010. doi:10.4049/jimmunol.0903879. PMID 20421648.  https://dx.doi.org/10.4049%2Fjimmunol.0903879
  55. "Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut". American Journal of Hematology 85 (8): 560–3. Aug 2010. doi:10.1002/ajh.21760. PMID 20568250.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2910184
  56. "LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L". Blood 117 (20): 5532–40. May 2011. doi:10.1182/blood-2010-11-318675. PMID 21422469.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3109721
  57. "MHC class II engagement by its ligand LAG-3 (CD223) contributes to melanoma resistance to apoptosis". Journal of Immunology 186 (9): 5173–83. May 2011. doi:10.4049/jimmunol.1002050. PMID 21441454.  https://dx.doi.org/10.4049%2Fjimmunol.1002050
  58. "Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3". Journal of Immunology 187 (7): 3493–8. Oct 2011. doi:10.4049/jimmunol.1100714. PMID 21873518.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3178660
  59. "Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection". Nature Immunology 13 (2): 188–95. Feb 2012. doi:10.1038/ni.2180. PMID 22157630.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3262959
  60. "Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape". Cancer Research 72 (4): 917–27. Feb 2012. doi:10.1158/0008-5472.CAN-11-1620. PMID 22186141.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3288154
  61. "Construction, and in vitro and in vivo analyses of tetravalent immunoadhesins". Journal of Microbiology and Biotechnology 22 (8): 1066–76. Aug 2012. doi:10.4014/jmb.1201.01026. PMID 22713982.  https://dx.doi.org/10.4014%2Fjmb.1201.01026
  62. "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine 19 (6): 739–46. Jun 2013. doi:10.1038/nm.3179. PMID 23624599.  https://dx.doi.org/10.1038%2Fnm.3179
  63. "Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation". PLOS ONE 9 (1): e86551. January 27, 2014. doi:10.1371/journal.pone.0086551. PMID 24475140. Bibcode: 2014PLoSO...986551S.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3903521
  64. "Lymphocyte activation gene-3 expression defines a discrete subset of HIV-specific CD8+ T cells that is associated with lower viral load". AIDS Research and Human Retroviruses 30 (6): 535–41. Jun 2014. doi:10.1089/AID.2012.0195. PMID 24180338.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4046223
  65. "Alternative activation of human plasmacytoid DCs in vitro and in melanoma lesions: involvement of LAG-3". The Journal of Investigative Dermatology 134 (7): 1893–902. Jul 2014. doi:10.1038/jid.2014.29. PMID 24441096.  https://dx.doi.org/10.1038%2Fjid.2014.29
  66. "Trafficking of LAG-3 to the surface on activated T cells via its cytoplasmic domain and protein kinase C signaling". Journal of Immunology 193 (6): 3101–12. Sep 2014. doi:10.4049/jimmunol.1401025. PMID 25108024.  https://dx.doi.org/10.4049%2Fjimmunol.1401025
  67. "TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses". Nature Communications 6 (6329): 6329. February 19, 2015. doi:10.1038/ncomms7329. PMID 25695838. Bibcode: 2015NatCo...6.6329O.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4346620
  68. "LAG3 expression in active Mycobacterium tuberculosis infections". The American Journal of Pathology 185 (3): 820–33. Mar 2015. doi:10.1016/j.ajpath.2014.11.003. PMID 25549835.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4348466
  69. "Characterization and functional studies of forkhead box protein 3(-) lymphocyte activation gene 3(+) CD4(+) regulatory T cells induced by mucosal B cells". Clinical and Experimental Immunology 180 (2): 316–28. May 2015. doi:10.1111/cei.12583. PMID 25581421.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4408166
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