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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Electrolyte Imbalance
Electrolyte imbalance, or water-electrolyte imbalance, is an abnormality in the concentration of electrolytes in the body. Electrolytes play a vital role in maintaining homeostasis in the body. They help to regulate heart and neurological function, fluid balance, oxygen delivery, acid–base balance and much more. Electrolyte imbalances can develop by consuming too little or too much electrolyte as well as excreting too little or too much electrolyte. Examples of electrolytes include: calcium, chloride, magnesium, phosphate, potassium, and sodium. Electrolyte disturbances are involved in many disease processes, and are an important part of patient management in medicine. The causes, severity, treatment, and outcomes of these disturbances can differ greatly depending on the implicated electrolyte. The most serious electrolyte disturbances involve abnormalities in the levels of sodium, potassium or calcium. Other electrolyte imbalances are less common and often occur in conjunction with major electrolyte changes. The kidney is the most important organ in maintaining appropriate fluid and electrolyte balance, but other factors such as hormonal changes and physiological stress play a role.
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  • 02 Nov 2022
Topic Review
Alsophila Dealbata
Alsophila dealbata, synonym Cyathea dealbata, commonly known as the silver fern or silver tree-fern, or as ponga /ˈpɒŋə/ or punga /ˈpʌŋə/ (from Māori kaponga or ponga), is a species of medium-sized tree fern, endemic to New Zealand. The fern is usually recognisable by the silver-white colour of the under-surface of mature fronds. It is a symbol commonly associated with the country both overseas and by New Zealanders themselves.
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  • 02 Nov 2022
Topic Review
Ophrysia
The Himalayan quail (Ophrysia superciliosa) or mountain quail, is a medium-sized quail belonging to the pheasant family. It was last reported in 1876 and is feared extinct. This species was known from only 2 locations (and 12 specimens) in the western Himalayas in Uttarakhand, north-west India . The last verifiable record was in 1876 near the hill station of Mussoorie.
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  • 02 Nov 2022
Topic Review
Minister President (Germany)
The Minister President (Ministerpräsident) is the head of state and government in thirteen of Germany sixteen states. In the three states of Berlin, Free Hanseatic City of Bremen and Free and Hanseatic City of Hamburg the heads of the state hold different titles: In the since-1952 defunct states of Baden and Württemberg-Hohenzollern the heads of state held the title State President (Staatspräsident). Nevertheless, in Germany it is common practice, to call all sixteen heads of the states ministers president if they are referred to collectively. For example, the regular meetings of the sixteen office-holders are called Conference of Ministers President (Ministerpräsidentenkonferenz).
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  • 02 Nov 2022
Topic Review
Panama Papers (South America)
The Panama Papers are 11.5 million leaked documents that detail financial and attorney–client information for more than 214,488 offshore entities. The documents, some dating back to the 1970s, were created by, and taken from, Panamanian law firm and corporate service provider Mossack Fonseca, and were leaked in 2015 by an anonymous source. This page details related allegations, reactions, and investigations, in South America.
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  • 02 Nov 2022
Topic Review
Gravity Field and Steady-State Ocean Circulation Explorer
The Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) was the first of ESA's Living Planet Programme satellites intended to map in unprecedented detail the Earth's gravity field. The spacecraft's primary instrumentation was a highly sensitive gravity gradiometer consisting of three pairs of accelerometers which measured gravitational gradients along three orthogonal axes. Launched on 17 March 2009, GOCE mapped the deep structure of the Earth's mantle and probed hazardous volcanic regions. It brought new insight into ocean behaviour; this in particular, was a major driver for the mission. By combining the gravity data with information about sea surface height gathered by other satellite altimeters, scientists were able to track the direction and speed of geostrophic ocean currents. The low orbit and high accuracy of the system greatly improved the known accuracy and spatial resolution of the geoid (the theoretical surface of equal gravitational potential on the Earth). The satellite's unique arrow shape and fins helped keep GOCE stable as it flew through the thermosphere at a comparatively low altitude of 255 kilometres (158 mi). Additionally, an ion propulsion system continuously compensated for the variable deceleration due to air drag without the vibration of a conventional chemically powered rocket engine, thus limiting the errors in gravity gradient measurements caused by non-gravitational forces and restoring the path of the craft as closely as possible to a purely inertial trajectory. After running out of propellant, the satellite began dropping out of orbit and made an uncontrolled reentry on 11 November 2013.
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  • 02 Nov 2022
Topic Review
Learning Styles
Learning styles refer to a range of competing and debunked theories that aim to account for differences in individuals' learning. Many theories share the proposition that humans can be classified according to their 'style' of learning, but differ in how the proposed styles should be defined, categorized and assessed.:8 A common concept is that individuals differ in how they learn.:266 The idea of individualized learning styles became popular in the 1970s, and has greatly influenced education despite the criticism that the idea has received from some researchers.:107–108 Proponents recommend that teachers have to run a needs analysis to assess the learning styles of their students and adapt their classroom methods to best fit each student's learning style. Although there is ample evidence that individuals express personal preferences for how they prefer to receive information,:108 few studies have found any validity in using learning styles in education.:267 Critics say there is no consistent evidence that identifying an individual student's learning style and teaching for specific learning styles produces better student outcomes.:33 Since 2012, Learning Styles have often been referred to as a "neuromyth" in education. There is evidence of empirical and pedagogical problems related to forcing learning tasks to "correspond to differences in a one-to-one fashion". Studies contradict the widespread "meshing hypothesis" that a student will learn best if taught in a method deemed appropriate for the student's learning style. However, a 2020 systematic review suggested that a majority (89%) of educators around the world continue to believe that the meshing hypothesis is correct. Studies further show that teachers cannot assess the learning style of their students accurately.
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  • 02 Nov 2022
Topic Review
GSK-3 Inhibitor
Glycogen synthase, an enzyme that is responsible in glycogen synthesis, is activated by glucose 6-phosphate (G6P), and inhibited by glycogen synthase kinases (GSK3). Those two mechanisms play an important role in glycogen metabolism. Glycogen synthase kinase (GSK-3) is a serine/threonine kinase that phosphorylate either threonine or serine, and this phosphorylation permits a variety of biological activities as glycogen metabolism, cell signaling, cellular transport, and others. GS inhibition by GSK-3β leads to a decrease in glycogen synthesis in the liver and muscles, along with increased blood glucose or hyperglycemia. This is why GSK-3β is associated with the pathogenesis and progression of many diseases, such as diabetes, obesity, and cancer. Human GSK-3 has two isoforms, α and β. It is active in resting cells and is inhibited by several hormones such as insulin, endothelial growth factor, and platelet-derived growth factor. Insulin inactivates it by phosphorylation of the specific serine residues Ser21 and Ser9 in GSK-3 isoforms α and β, respectively. In a phosphatidylinositol 3-kinase-dependent way. Glycogen synthase kinase inhibitors are different chemotypes and have variable mechanisms of action; they may be cations, from natural sources, synthetic ATP and non-ATP competitive inhibitors and substrate-competitive inhibitors. GSK3 is a bi-lobar architecture with N-terminal and C-terminal, the N-terminal is responsible for ATP binding and C-terminal which is called as activation loop mediates the kinase activity, Tyrosine located at the C-terminal it essential for full GSK3 activity.
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  • 02 Nov 2022
Topic Review
Bebo
Bebo was a social networking website launched in 2005, that now describes itself as "a company that dreams up ideas for fun social apps;" Grant Denholm, the man behind the Bebo relaunch, has confirmed that the site will not be returning as a social network but as a company that makes social apps. The company launched the app Blab in early 2014; it closed in 2016. In December 2014 a new version of Bebo launched as an avatar hashtag messaging app. As of July 2013, it is owned and operated by its founders Michael Birch and Xochi Birch, who took over from Criterion Capital Partners after the company declared bankruptcy.
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  • 02 Nov 2022
Topic Review
Saghatheriidae
Hyraxes (from grc ὕραξ (húrax) 'shrewmouse'), also called dassies, are small, thickset, herbivorous mammals in the order Hyracoidea. Hyraxes are well-furred, rotund animals with short tails. Typically, they measure between 30 and 70 cm (12 and 28 in) long and weigh between 2 and 5 kg (4 and 11 lb). They are superficially similar to pikas and marmots, but are more closely related to elephants and sea cows. Hyraxes have a life span from 9 to 14 years. Five extant species are recognised: the rock hyrax (Procavia capensis) and the yellow-spotted rock hyrax (Heterohyrax brucei), which both live on rock outcrops, including cliffs in Ethiopia and isolated granite outcrops called koppies in southern Africa; the western tree hyrax (Dendrohyrax dorsalis), southern tree hyrax (D. arboreus), and eastern tree hyrax (D. validus). Their distribution is limited to Africa, except for P. capensis, which is also found in the Middle East.
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  • 02 Nov 2022
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