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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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List of Psychiatric Medications by Condition Treated
This is a list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress. The list is ordered alphabetically according to the condition or conditions, then by the generic name of each medication. The list is not exhaustive and not all drugs are used regularly in all countries. Some medications treat multiple conditions and appear multiple times.
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  • 09 Nov 2022
Topic Review
Memory-Prediction Framework
The memory-prediction framework is a theory of brain function created by Jeff Hawkins and described in his 2004 book On Intelligence. This theory concerns the role of the mammalian neocortex and its associations with the hippocampi and the thalamus in matching sensory inputs to stored memory patterns and how this process leads to predictions of what will happen in the future.
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  • 09 Nov 2022
Topic Review
Hedgehog Pathway Inhibitors
Hedgehog pathway inhibitors are small molecules that inhibit the activity of a component of the Hedgehog signaling pathway. Due to the role of aberrant Hedgehog signaling in tumor progression and cancer stem cell maintenance across cancer types, inhibition of the Hedgehog signaling pathway can be a useful strategy for restricting tumor growth and for preventing the recurrence of the disease post-surgery, post-radiotherapy, or post-chemotherapy. Thus, Hedgehog pathway inhibitors are an important class of anti-cancer drugs. At least three Hedgehog pathway inhibitors have been approved by the Food and Drug Administration (FDA) for cancer treatment. These include Vismodegib and Erismodegib, both inhibitors of Smoothened (SMO), which are being used for the treatment of basal cell carcinoma. Arsenic Trioxide, an inhibitor of GLI transcription factors, is being used for the treatment of acute promyelocytic leukemia. In addition, multiple other Hedgehog pathway inhibitors are in different phases of clinical trials.
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  • 09 Nov 2022
Topic Review
Basalt
Basalt (/bəˈsɔːlt, ˈbæsɒlt, -sɔːlt/) is a mafic extrusive igneous rock formed from the rapid cooling of magnesium-rich and iron-rich lava exposed at or very near the surface of a terrestrial planet or a moon. More than 90% of all volcanic rock on Earth is basalt. Basalt lava has a low viscosity, due to its low silica content, resulting in rapid lava flows that can spread over great areas before cooling and solidification. Flood basalt describes the formation in a series of lava basalt flows.
  • 7.2K
  • 09 Nov 2022
Topic Review
Paschen's Law
Paschen's law is an equation that gives the breakdown voltage, that is, the voltage necessary to start a discharge or electric arc, between two electrodes in a gas as a function of pressure and gap length. It is named after Friedrich Paschen who discovered it empirically in 1889. Paschen studied the breakdown voltage of various gases between parallel metal plates as the gas pressure and gap distance were varied: For a given gas, the voltage is a function only of the product of the pressure and gap length. The curve he found of voltage versus the pressure-gap length product (right) is called Paschen's curve. He found an equation that fit these curves, which is now called Paschen's law. At higher pressures and gap lengths, the breakdown voltage is approximately proportional to the product of pressure and gap length, and the term Paschen's law is sometimes used to refer to this simpler relation. However, this is only roughly true, over a limited range of the curve.
  • 13.6K
  • 09 Nov 2022
Topic Review
Other
In phenomenology, the terms the Other and the Constitutive Other identify the other human being, in their differences from the Self, as being a cumulative, constituting factor in the self-image of a person; as acknowledgement of being real; hence, the Other is dissimilar to and the opposite of the Self, of Us, and of the Same. The Constitutive Other is the relation between the personality (essential nature) and the person (body) of a human being; the relation of essential and superficial characteristics of personal identity that corresponds to the relationship between opposite, but correlative, characteristics of the Self, because the difference is inner-difference, within the Self. The condition and quality of Otherness (the characteristics of the Other) is the state of being different from and alien to the social identity of a person and to the identity of the Self. In the discourse of philosophy, the term Otherness identifies and refers to the characteristics of Who? and What? of the Other, which are distinct and separate from the Symbolic order of things; from the Real (the authentic and unchangeable); from the æsthetic (art, beauty, taste); from political philosophy; from social norms and social identity; and from the Self. Therefore, the condition of Otherness is a person's non-conformity to and with the social norms of society; and Otherness is the condition of disenfranchisement (political exclusion), effected either by the State or by the social institutions (e.g., the professions) invested with the corresponding socio-political power. Therefore, the imposition of Otherness alienates the person labelled as "the Other" from the centre of society, and places him or her at the margins of society, for being the Other. The term Othering describes the reductive action of labelling and defining a person as a subaltern native, as someone who belongs to the socially subordinate category of the Other. The practice of Othering excludes persons who do not fit the norm of the social group, which is a version of the Self; likewise, in human geography, the practice of othering persons means to exclude and displace them from the social group to the margins of society, where mainstream social norms do not apply to them, for being the Other.
  • 3.6K
  • 09 Nov 2022
Topic Review
Climate Oscillation
A climate oscillation or climate cycle is any recurring cyclical oscillation within global or regional climate, and is a type of climate pattern. These fluctuations in atmospheric temperature, sea surface temperature, precipitation or other parameters can be quasi-periodic, often occurring on inter-annual, multi-annual, decadal, multidecadal, century-wide, millennial or longer timescales. They are not perfectly periodic and a Fourier analysis of the data does not give a sharp spectrum. A prominent example is the El Niño Southern Oscillation, involving sea surface temperatures along a stretch of the equatorial Central and East Pacific Ocean and the western coast of tropical South America, but which affects climate worldwide. Records of past climate conditions are recovered through geological examination of proxies, found in glacier ice, sea bed sediment, tree ring studies or otherwise.
  • 3.0K
  • 09 Nov 2022
Topic Review
Authenticity in Art
Authenticity in art is the different ways in which a work of art or an artistic performance may be considered authentic. Denis Dutton distinguishes between nominal authenticity and expressive authenticity. The first refers to the correct identification of the author of a work of art, to how closely a performance of a play or piece of music conforms to the author's intention, or to how closely a work of art conforms to an artistic tradition. The second sense refers to how much the work possesses original or inherent authority, how much sincerity, genuineness of expression, and moral passion the artist or performer puts into the work. A quite different concern is the authenticity of the experience, which may be impossible to achieve. A modern visitor to a museum may not only see an object in a very different context from that which the artist intended, but may be unable to understand important aspects of the work. The authentic experience may be impossible to recapture. Authenticity is a requirement for inscription upon the UNESCO World Heritage List. According to the Nara Document on Authenticity, it can be expressed through 'form and design; materials and substance; use and function; traditions and techniques; location and setting; spirit and feeling; and other internal and external factors.'
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  • 09 Nov 2022
Topic Review
Psychoanalysis
Psychoanalysis (from Greek: Ancient Greek: + Ancient Greek:) is a set of theories and therapeutic techniques that deal in part with the unconscious mind, and which together form a method of treatment for mental disorders. The discipline was established in the early 1890s by Austrian neurologist Sigmund Freud, who retained the term psychoanalysis for his own school of thought. Freud's work stems partly from the clinical work of Josef Breuer and others. Psychoanalysis was later developed in different directions, mostly by students of Freud, such as Alfred Adler and his collaborator, Carl Gustav Jung, as well as by neo-Freudian thinkers, such as Erich Fromm, Karen Horney, and Harry Stack Sullivan. Psychoanalysis is a controversial discipline, and its effectiveness as a treatment has been contested. It has been largely replaced by the similar but broader psychodynamic psychotherapy in the mid-20th century. although it retains a salient influence within psychiatry. Psychoanalytic concepts are also widely used outside the therapeutic arena, in areas such as psychoanalytic literary criticism, as well as in the analysis of film, fairy tales, philosophical perspectives as Freudo-Marxism and other cultural phenomena.
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  • 09 Nov 2022
Topic Review
Circular Connector
The term Circular Connector applies to any electrical connector possessing multipin interconnects with cylindrical contact housings and circular contact interface geometries. Circular connectors are selected for ease of engagement and disengagement, their ability to conveniently house different types of contacts, their wide range of allowable contact voltages and currents, their ease of environmental sealing and their rugged mechanical performance. In military, aerospace, and other high-reliability applications, the MIL-DTL-5015 and MIL-DTL-38999 are among the most commonly specified types. The primary disadvantage of the circular design is loss of panel space when used in arrays when compared to rectangular connectors.
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