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HandWiki. Hedgehog Pathway Inhibitors. Encyclopedia. Available online: https://encyclopedia.pub/entry/33677 (accessed on 26 September 2026).
HandWiki. Hedgehog Pathway Inhibitors. Encyclopedia. Available at: https://encyclopedia.pub/entry/33677. Accessed September 26, 2026.
HandWiki. "Hedgehog Pathway Inhibitors" Encyclopedia, https://encyclopedia.pub/entry/33677 (accessed September 26, 2026).
HandWiki. (2022, November 09). Hedgehog Pathway Inhibitors. In Encyclopedia. https://encyclopedia.pub/entry/33677
HandWiki. "Hedgehog Pathway Inhibitors." Encyclopedia. Web. 09 November, 2022.
Hedgehog Pathway Inhibitors
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The content is sourced from: https://handwiki.org/wiki/Biology:Hedgehog_pathway_inhibitors

Hedgehog pathway inhibitors are small molecules that inhibit the activity of a component of the Hedgehog signaling pathway. Due to the role of aberrant Hedgehog signaling in tumor progression and cancer stem cell maintenance across cancer types, inhibition of the Hedgehog signaling pathway can be a useful strategy for restricting tumor growth and for preventing the recurrence of the disease post-surgery, post-radiotherapy, or post-chemotherapy. Thus, Hedgehog pathway inhibitors are an important class of anti-cancer drugs. At least three Hedgehog pathway inhibitors have been approved by the Food and Drug Administration (FDA) for cancer treatment. These include Vismodegib and Erismodegib, both inhibitors of Smoothened (SMO), which are being used for the treatment of basal cell carcinoma. Arsenic Trioxide, an inhibitor of GLI transcription factors, is being used for the treatment of acute promyelocytic leukemia. In addition, multiple other Hedgehog pathway inhibitors are in different phases of clinical trials.

basal cell cancer stem cell small molecules

References

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