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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Automated Insulin Delivery Systems
Automated insulin delivery systems are automated (or semi-automated) systems designed to assist people with diabetes, primarily type 1, by automatically adjusting insulin delivery to help them control their blood glucose levels. Currently available systems (as of October, 2020) can only deliver (and regulate delivery of) a single hormone- insulin. Other systems currently in development aim to improve on current systems by adding one or more additional hormones that can be delivered as needed, providing something closer to the endocrine functionality of a healthy pancreas. The endocrine functionality of the pancreas is provided by islet cells which produce the hormones insulin and glucagon. Artificial pancreatic technology mimics the secretion of these hormones into the bloodstream in response to the body's changing blood glucose levels. Maintaining balanced blood sugar levels is crucial to the function of the brain, liver, and kidneys. Therefore, for type 1 patients, it is necessary that the levels be kept balanced when the body cannot produce insulin itself. Automated insulin delivery systems are often referred to using the term artificial pancreas, but the term has no precise, universally accepted definition. For uses other than automated insulin delivery, see Artificial pancreas (disambiguation).
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  • 25 Nov 2022
Topic Review
Global Intellectual History
Global intellectual history is the history of thought in the world across the span of human history, often understood from the invention of writing to the present. The discipline is part of the field of intellectual history, also known as history of ideas, and can also be termed global history of ideas. In recent years, historians such as C. A. Bayly have been calling for a global intellectual history to be written. They stress that to understand the history of ideas across time and space, it is necessary to study from a cosmopolitan or global point of view the connections and the parallels in intellectual development across the world. Yet these separate histories and their convergence in the modern period have yet to be brought together into a single historical narrative. Nonetheless, some global histories, like Bayly's own Birth of the Modern World or David Armitage's The Declaration of Independence: A Global History offer contributions to the huge and necessarily collaborative project of writing the history of thought in a comparative and especially connective way. Other examples of transnational intellectual histories include Albert Hourani's Arabic Thought in the Liberal Age. In 2013, Samuel Moyn and Andrew Sartori published the anthology Global Intellectual History. In 2016, the Routledge journal Global Intellectual History (ed. Richard Whatmore) was established. In January 2019 the historian J. G. A. Pocock stated in that journal: "The beginnings of the ‘global’ critique are well known and may as well be accepted as common ground. They reduce to the assertion that ‘Cambridge’ scholarship in this field is ‘Eurocentric’; that is, that it has dealt exclusively with the ‘political thought’ generated in the Greco-Roman Mediterranean, transmitted to medieval and modern Europe, and taken up in the Euro-colonized Americas and a world (or ‘globe’) subjected to European or ‘western’ domination. This is obviously true, and calls for reformation." It has been argued that the historians of ideas Arthur O. Lovejoy and Hajime Nakamura should be read as modern founders of the discipline global intellectual history. Other recent contributors are Siep Stuurman, Sanjay Subrahamnyam, and Martin Mulsow. The origins of human intellectual history arguably began before the invention of writing, but historians are by definition only concerned with the eras in which writing was present. In the spirit of a historiographic project that is relevant to all human beings and that has yet to be completed, the sections that follow briefly review currents of thought in pre-modern and modern history of the world, and are organized by geographic area (and within each section, chronologically).
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  • 25 Nov 2022
Topic Review
Portraits of the Historical Jesus
Portraits of the historical Jesus refers to the various biographies of Jesus that have been constructed in the three separate scholarly quests for the historical Jesus that have taken place in the past two centuries, each with distinct characteristics and developing new and different research criteria. The portraits of Jesus that have been constructed in these processes have often differed from each other, and from the dogmatic image portrayed in the gospel accounts. These portraits include that of Jesus as an apocalyptic prophet, charismatic healer, Cynic philosopher, Jewish Messiah and prophet of social change, but there is little scholarly agreement on a single portrait, or the methods needed to construct it. There are, however, overlapping attributes among the various portraits, and scholars who differ on some attributes may agree on others. By the 21st century scholars began to focus on what is historically probable and plausible about Jesus.
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  • 25 Nov 2022
Topic Review
Amyloid Precursor Protein
Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity , and iron export. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.
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  • 25 Nov 2022
Topic Review
Radio Atmospheric
A radio atmospheric signal or sferic (sometimes also spelled "spheric") is a broadband electromagnetic impulse that occurs as a result of natural atmospheric lightning discharges. Sferics may propagate from their lightning source without major attenuation in the Earth–ionosphere waveguide, and can be received thousands of kilometres from their source. On a time-domain plot, a sferic may appear as a single high-amplitude spike in the time-domain data. On a spectrogram, a sferic appears as a vertical stripe (reflecting its broadband and impulsive nature) that may extend from a few kHz to several tens of kHz, depending on atmospheric conditions. Sferics received from about 2,000 kilometres' distance or greater have their frequencies slightly offset in time, producing tweeks. When the electromagnetic energy from a sferic escapes the Earth-ionosphere waveguide and enters the magnetosphere, it becomes dispersed by the near-Earth plasma, forming a whistler signal. Because the source of the whistler is an impulse (i.e., the sferic), a whistler may be interpreted as the impulse response of the magnetosphere (for the conditions at that particular instant).
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  • 25 Nov 2022
Topic Review
Arsenate Minerals
Arsenate minerals usually refer to the naturally occurring orthoarsenates, possessing the (AsO4)3− anion group and, more rarely, other arsenates with anions like AsO3(OH)2− (also written HAsO42−) (example: pharmacolite Ca(AsO3OH).2H2O) or (very rarely) [AsO2(OH)2]− (example: andyrobertsite). Arsenite minerals are much less common. Both the Dana and the Strunz mineral classifications place the arsenates in with the phosphate minerals. Example arsenate minerals include:
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  • 25 Nov 2022
Topic Review
Demonic Possession
Demonic possession is the belief that a person's actions are controlled by an alien spirit, demon, or entity. Symptoms of demonic possession commonly claimed by victims include missing memories, perceptual distortions, loss of a sense of control, and hyper-suggestibility. Erika Bourguignon found in a study of 488 societies worldwide, seventy-four percent believe in possession by spirits, with the highest numbers of beliefs in Pacific cultures and the lowest incidence among Native Americans of both North and South America.
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  • 25 Nov 2022
Topic Review
Carbon Literacy
Carbon Literacy is the awareness of climate change and the climate impacts of mankind's everyday actions. The term has been used in a range of contexts in scientific literature and in casual usage (see Research), but is most associated with The Carbon Literacy Project (CLP).
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  • 25 Nov 2022
Topic Review
Comparison of Notetaking Software
The tables below compare features of notable note-taking software.
  • 1.1K
  • 28 Nov 2022
Topic Review
The Amazing Bulk
The Amazing Bulk is a 2012 American direct-to-video superhero film directed by Lewis Schoenbrun. Considered to be a mockbuster of the Marvel Studios film The Incredible Hulk, as well as other media featuring the Hulk character, the film's settings and visuals are almost entirely all reused stock imagery, graphics, and video purchased from various websites.
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  • 25 Nov 2022
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