Summary

NMR has revolutionized structure determination and is a technique used in a very wide range of disciplines from biology, chemistry, material science, polymers and biopolymers, to drug design, food science, etc. Although the technique has been around for more than seventy years, it is still in development, both instrumentally with higher magnetic fields, better probes, improving pulse sequences and signal manipulation, and in solid state NMR with higher spinning speeds, and in relation to improving signal to noise ratios. It is the aim to collect a number of contributions covering recent progress both with respect to techniques and to new uses of NMR in its entire range of applications.

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Topic Review
Polysaccharide Sequence Determination
NMR analysis combined with statistical modeling offers a useful approach to investigate the microstructures of biobased polymers. In particular, this approach may be used to study the microstructures of polysaccharides. If the polysaccharides are composed of two or three monosaccharide units, and the NMR spectral features are sensitive to the different sequence placements of these units, then a detailed analysis of a polysaccharide (or its fractions) can be made by NMR with the help of statistical modeling.   
  • 482
  • 12 Mar 2024
Topic Review
Radiological Diagnostic Approach and Spinal Cord Tumor
Differentiating neoplastic from non-neoplastic spinal cord pathologies may be challenging due to overlapping clinical and radiological features. Spinal cord tumors, which comprise only 2–4% of central nervous system tumors, are rarer than non-tumoral myelopathies of inflammatory, vascular, or infectious origins. The risk of neurological deterioration and the high rate of false negatives or misdiagnoses associated with spinal cord biopsies require a cautious approach.
  • 507
  • 08 Mar 2024
Topic Review
Cardiac Magnetic Resonance (CMR) Mapping
Cardiac magnetic resonance (CMR) imaging has witnessed substantial progress with the advent of parametric mapping techniques, most notably T1 and T2 mapping. These advanced techniques provide valuable insights into a wide range of cardiac conditions, including ischemic heart disease, cardiomyopathies, inflammatory cardiomyopathies, heart valve disease, and athlete’s heart. Mapping could be the first sign of myocardial injury and oftentimes precedes symptoms, changes in ejection fraction, and irreversible myocardial remodeling. The ability of parametric mapping to offer a quantitative assessment of myocardial tissue properties addresses the limitations of conventional CMR methods, which often rely on qualitative or semiquantitative data. However, challenges persist, especially in terms of standardization and reference value establishment, hindering the wider clinical adoption of parametric mapping. Future developments should prioritize the standardization of techniques to enhance their clinical applicability, ultimately optimizing patient care pathways and outcomes.
  • 384
  • 19 Jan 2024
Topic Review
X-ray and Nuclear Spectroscopies for Non-Gadolinium MRI Agents
Nanoparticulated manganese cyanoferrate (K2Mn[Fe(CN)6]) and its analogs are non-toxic complexes and prime candidates for the next generation non-gadolinium magnetic resonance imaging (MRI) agents. L-edge X-ray absorption spectroscopy (L-XAS) and 57Fe specific nuclear resonant vibrational spectroscopy (NRVS) can be combined as a modern spectroscopic method to evaluate the element specific and isotope specific information about the oxidation states, electronic spin states and the coordination environments for the metals inside these complexes.
  • 474
  • 08 Jan 2024
Topic Review
Practical Aspects of Nuclear Magnetic Resonance Application
Nuclear magnetic resonance (NMR) is a primary method of measurement according to metrology standards. It has been proven to have good reproducibility. NMR spectra are evaluated numerically, including chemical shifts, coupling constants, and signal integrals, which lead to quantitative results.
  • 449
  • 13 Dec 2023
Topic Review
Cancer and Pregnancy in Post-Roe v. Wade Era
Cancer during pregnancy, affecting 1 in 1000 pregnancies, is rising in incidence due to delayed childbearing and improved detection. Common types include breast cancer, melanoma and cervical cancer and Hodgkin’s Lymphoma. There are several physiological changes that occur during pregnancy that make its management a challenge to clinicians. Managing it requires multidisciplinary approaches and cautious test interpretation due to overlapping symptoms. To minimize fetal radiation exposure, non-ionizing imaging is preferred, and the interpretation of tumor markers is challenging due to inflammation and pregnancy effects.
  • 456
  • 03 Nov 2023
Topic Review
Magnetic Resonance Imaging of the Gastrointestinal Tract
Magnetic resonance imaging (MRI) performed with the more advanced imaging techniques allows an accurate assessment of many intestinal disorders, particularly inflammatory bowel disease and rectal cancer; in most of these diseases, MRI is invaluable for diagnosis, staging, and monitoring under treatment. Several MRI parameters are currently considered activity biomarkers for inflammatory and neoplastic diseases. Furthermore, in younger patients with acute or chronic GI disease, MRI can be safely used for short-term follow-up studies in many critical clinical situations because it is radiation-free. MRI assessment of functional gastro-esophageal and small bowel disorders is still in its infancy but very promising, while it is well established and widely used for dynamic assessment of anorectal and pelvic floor dysfunction; MRI motility biomarkers have also been described. 
  • 687
  • 07 Aug 2023
Topic Review
13C Solid-State NMR Application to Waste Composting
13C solid-state Nuclear Magnetic Resonance (SSNMR) has often been applied to follow the transformation of organic matter during waste composting to produce soil amendments, as well as to assess the quality of the products and the effectiveness of the treatment. 
  • 757
  • 27 Mar 2023
Topic Review
NMR-Based Metabolomics in Food Quality Assessment
The ability of nuclear magnetic resonance spectroscopy (NMR) to extract chemical information from a complex mixture is invaluable and widely described in literature. Many applications of this technique in the foodomics field have highlighted how NMR could characterize food matrices, and it can be used all along its “life chain”: from farm to fork and from fork to the digestion process. 
  • 765
  • 19 Jan 2023
Topic Review
Functional MRI in Radiology
Although the international community for human brain mapping has met since 1995, the researchers fascinated by human brain function are still young and innovative. However, the impact of functional magnetic resonance imaging (fMRI) on prognosis and treatment decisions is restricted, even though standardized methods have been developed. The tradeoff between the groundbreaking studies on brain function and the attempt to provide reliable biomarkers for clinical decisions is large. 
  • 923
  • 25 Nov 2022
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