Summary

Organic synthesis is the tool for the preparation of small molecules with interesting biological and medicinal properties—new compounds with activity against diseases affecting humankind today such as cancer, metabolic disorders, neurodegenerative disorders or infectious diseases, as well as new syntheses of known drugs. New bioactive compounds are designed and synthesized to target key metabolic reactions in pathological processes as the first steps toward drug discovery. The crosstalk between synthetic and medicinal chemists enable a high impact of new synthetic methodologies in drug discovery. The aim is to highlight the role that organic synthesis plays in developing methods that may be exploited for finding lead compounds and drugs by the pharmaceutical industry.

Expand All
Entries
Topic Review
Polymeric Surfactants
Polymeric surfactants are surfactant molecules that have a polymeric backbone, which can be made up of various repeating units. These surfactants have both hydrophilic and hydrophobic segments, which allows them to interact with both water and oil. Polymeric surfactants are used in a variety of industrial applications, such as in the production of paints, adhesives, and coatings. They can improve the stability and performance of these products by reducing the surface tension and promoting the dispersion of pigments and fillers. In addition, polymeric surfactants are also used in the formulation of personal care products, such as shampoos, conditioners, and body washes. They can help to improve the texture and feel of these products, as well as enhance their cleaning and conditioning properties. One of the key advantages of polymeric surfactants is their ability to form stable micelles in solution. These micelles are aggregates of surfactant molecules that form a spherical structure with the hydrophobic segments on the inside and the hydrophilic segments on the outside. This allows for efficient emulsification of oil and water, which is important in a variety of industrial processes. Polymeric surfactants are a versatile class of surfactants that offer several unique properties and advantages in various applications. They are commonly used as emulsifiers, stabilizers, and thickening agents, and have potential applications in areas such as agriculture, oil and gas, and papermaking. Polymeric surfactants are a diverse class of surfactants that can be classified based on their composition, molecular weight, and degree of polymerization. They offer a range of unique properties and advantages in various applications, including cosmetics, food and beverage products, pharmaceuticals, and agriculture.
  • 1.5K
  • 24 Mar 2023
Topic Review
Synthesis of Cyclic Sulfoximines via C–H Bond Activation
Sulfoximines, a ubiquitous class of structural motifs, are widely present in bioactive molecules and functional materials that have received considerable attention from modern organic chemistry, pharmaceutical industries, and materials science. Sulfoximines have proved to be an effective directing group for C–H functionalization which was widely investigated for the synthesis of cyclic sulfoximines. C–H activation of sulfoximines has been widely considered to be an efficient method to construct complex scaffolds with potential bioactivities, especially since Bolm discovered the first efficient strategy of Rh-catalyzed annulation of sulfoximines and alkynes in 2013.
  • 615
  • 10 Feb 2023
Topic Review
Phosphorus Dendrimers as Physical Hydrogels and Their Properties
Hydrogels are hydrophilic, three-dimensional networks able to imprison large amounts of water and are largely used in pharmaceutical formulations. Hydrogels are frequently obtained from hydrophilic polymers, either natural, biohybrid, or synthetic. Phosphorus dendrimers possessing high multivalency provide the favorable positioning of functional groups at the surface, as well as cavities, in the three-dimensional organization of the scaffold and, therefore, can be considered potential gelators. The internal structure of phosphorus dendrimers is hydrophobic, whereas their terminal functions can be positively or negatively charged; thus, the whole structure becomes amphiphilic. 
  • 542
  • 09 Feb 2023
Topic Review
Synthesis of Variolins, Meridianins, and Meriolins
Marine natural products are a source of essential significance due to a plethora of highly diverse biological properties. The naturally occurring (aza)indole alkaloids variolin B (1), meridianins (2), and their synthetic hybrids meriolins (3) exhibit potent kinase inhibitory activities.
  • 583
  • 06 Feb 2023
Topic Review
Synthesis of Pyrazolo pyrano oxazoles
A simple and efficient synthetic route to the novel 3a,4-dihydro-3H,7H- and 4H,7H-pyrazolo[4′,3′:5,6]pyrano[4,3-c][1,2]oxazole ring systems from 3-(prop-2-en-1-yloxy)- or 3-(prop-2-yn-1-yloxy)-1H-pyrazole-4-carbaldehyde oximes has been developed by employing the intramolecular nitrile oxide cycloaddition (INOC) reaction as the key step.
  • 375
  • 06 Feb 2023
Topic Review
Lipid-Oligonucleotide Conjugates and the Development of RNA-Based Therapeutics
Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up into tissues and are susceptible to degradation by nucleases. For these reasons, the design and preparation of modified DNA/RNA derivatives with better stability and an ability to be produced at large scale with enhanced uptake properties is of vital importance.
  • 676
  • 01 Feb 2023
Topic Review
Fluorescent Organic Small Molecule Probes
Fluorescence imaging technology provides a visual tool for medicine, showing great potential in the fields of molecular biology, cellular immunology and oncology. In recent years, organic fluorescent probes have attracted much attention in the bioanalytical field. Among various organic fluorescent probes, fluorescent organic small molecule probes (FOSMPs) have become a research hotspot due to their excellent physicochemical properties, such as good photostability, high spatial and temporal resolution, as well as excellent biocompatibility. FOSMPs have proved to be suitable for in vivo bioimaging and detection. 
  • 568
  • 17 Jan 2023
Topic Review
Copper-Based Metal–Organic Frameworks for Click Chemistry
In the extensive terrain of catalytic procedures for the synthesis of organic molecules, metal–organic frameworks (MOFs) as heterogenous catalysts have been investigated in a variety of chemical processes, including Friedel–Crafts reactions, condensation reactions, oxidations, and coupling reactions, and utilized owing to their specific properties such as high porosity, tuneability, extraordinary catalytic activity, and recyclability.
  • 437
  • 13 Jan 2023
Topic Review
Applications of Metal–Organic Frameworks
Metal–organic frameworks (MOFs) have been broadly applied to numerous domains with a substantial surface area, tunable pore size, and multiple unsaturated metal sites. Hollow MOFs and their composites as well as their applications can be used in organic catalysis, electrochemical sensing, and adsorption separation.
  • 374
  • 06 Jan 2023
Topic Review
Gold(I)-Catalyzed Approaches with Arylalkyne Activation
Gold catalysts possess the advantages of water and oxygen resistance, with the possibility of catalyzing many novel chemical transformations, especially in the syntheses of small-molecule skeletons, in addition to achieving the rapid construction of multiple chemical bonds and ring systems in one step.
  • 613
  • 14 Feb 2023
  • Page
  • of
  • 18

Featured Entry Collections

>>