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Topic Review
Xia-Gibbs Syndrome
Xia-Gibbs syndrome is a neurological disorder characterized by weak muscle tone (hypotonia), mild to severe intellectual disability and delayed development.
  • 958
  • 24 Dec 2020
Topic Review
Xi (Alternate Reality Game)
Xi (UK: /ˈsaɪ/ or US: /ˈzaɪ/) was the world's first console-based and virtual world-based alternate reality game. It was a one-time-only play, unfolding in real time, and only available on the PlayStation 3 through the social gaming network, PlayStation Home. The game was an adventure to help find "Jess" and the meaning of Xi by collecting fragments and butterflies found in a series of secret areas in Home that changed frequently. The game also challenged the users to search for clues in the real world. The game was created by nDreams who released several spaces for Xi. The game was promoted through a teaser campaign of clues and hints during the month prior to its release on March 23, 2009. The clues were hidden in the Menu Pad and videos in the central meeting point. The game lasted a total of 12 weeks from its release. Xi and all of the corresponding spaces were exclusive to the European and North American versions of PlayStation Home, though there were also websites, videos, printed media and live events which were accessible to anyone. In September 2009, it was reported that the number of visits to the Xi spaces, including the ones after Xi's completion, had exceeded 5 million visits. A sequel, Xi: Continuum, was released in December 2012.
  • 395
  • 30 Oct 2022
Topic Review
XFEM for Material Design
The eXtended finite element method (XFEM) is a powerful tool for structural mechanics, assisting engineers and designers in understanding how a material architecture responds to stresses and consequently assisting the creation of mechanically improved structures. The XFEM method has unraveled the extraordinary relationships between material topology and fracture behavior in biological and engineered materials, enhancing peculiar fracture toughening mechanisms, such as crack deflection and arrest.
  • 160
  • 08 Feb 2024
Topic Review
Xeroderma Pigmentosum
Xeroderma pigmentosum, which is commonly known as XP, is an inherited condition characterized by an extreme sensitivity to ultraviolet (UV) rays from sunlight. This condition mostly affects the eyes and areas of skin exposed to the sun. Some affected individuals also have problems involving the nervous system. The signs of xeroderma pigmentosum usually appear in infancy or early childhood. Many affected children develop a severe sunburn after spending just a few minutes in the sun. The sunburn causes redness and blistering that can last for weeks. Other affected children do not get sunburned with minimal sun exposure, but instead tan normally. By age 2, almost all children with xeroderma pigmentosum develop freckling of the skin in sun-exposed areas (such as the face, arms, and lips); this type of freckling rarely occurs in young children without the disorder. In affected individuals, exposure to sunlight often causes dry skin (xeroderma) and changes in skin coloring (pigmentation). This combination of features gives the condition its name, xeroderma pigmentosum.  
  • 592
  • 24 Dec 2020
Topic Review
Xenograft Model in Animal Models of Cancer
Animal models of cancer may be classified in a variety of ways. Most simply, they are either spontaneous or induced and mammalian or non-mammalian. Alternatively, they may be categorized by the method of inducing cancer occurrence. A xenograft model involves the transplantation of cancer cells from one species (e.g., human) into a host animal of a different species (e.g., mouse).
  • 1.1K
  • 18 Oct 2022
Topic Review
Xenoestrogens and Phytoestrogens in Cancers
According to Global Cancer Statistics 2020, the burden of cancer incidence and mortality is rapidly growing worldwide. The epidemiological features of cancer reflect both the aging and growth of the population and the changes in the prevalence and distribution of the main cancer risk factors, several of which are particularly associated with the environment. Exogenous estrogens, such as synthetic industrial estrogenic compounds (xenoestrogens) and estrogenic molecules from plants (phytoestrogens), are environmental factors that potentially cause various cancers through their interactions with cellular signaling processes involving estrogen signaling pathways.
  • 465
  • 25 Aug 2021
Topic Review
Xenobiotics Modulating Aryl Hydrocarbon Receptor in Energy Homeostasis
There are fundamental sex differences in the regulation of energy homeostasis. Better understanding of the underlying mechanisms of energy balance that account for this asymmetry will assist in developing sex-specific therapies for sexually dimorphic diseases such as obesity. Multiple organs, including the hypothalamus and adipose tissue, play vital roles in the regulation of energy homeostasis, which are regulated differently in males and females. Various neuronal populations, particularly within the hypothalamus, such as arcuate nucleus (ARC), can sense nutrient content of the body by the help of peripheral hormones such leptin, derived from adipocytes, to regulate energy homeostasis. Substances from diet and environmental contaminants can exert insidious effects on energy metabolism, acting peripherally through the aryl hydrocarbon receptor (AhR). Developmental AhR activation can impart permanent alterations of neuronal development that can manifest a number of sex-specific physiological changes, which sometimes become evident only in adulthood. AhR is being investigated as a potential target for treating obesity. The consensus is that impaired function of the receptor protects from obesity in mice. AhR also modulates sex steroid receptors.
  • 389
  • 01 Aug 2022
Topic Review
Xenobiotic-Metabolizing Enzymes in Trematodes
Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding of anthelmintic biotransformation pathways in parasites should clarify factors that can modulate therapeutic potency of anthelmintics in use and may lead to the discovery of synergistic compounds for combination treatments.
  • 411
  • 09 Dec 2022
Topic Review
Xenobiotic Pollution and Its Impact on the Environment
In the industrial revolution and urbanization era, the global environment’s poisoning by a complex mixture of xenobiotics has become a major environmental threat worldwide. Xenobiotic contaminants such as azodyes, phenolics, polycyclic aromatic hydrocarbons (PAHs), halogenated compounds, personal care products (PCPs), pharmaceuticals’ active compounds (PhACs), pesticides, nitroaromatic compounds, triazines, and chlorinated compounds adversely affect the environment by their long-term persistence and slow or no biodegradation in the ecosystems. Xenobiotic pollution of the environment is a global concern caused by anthropogenic activities such as urbanization and population expansion. The enormous amounts of harmful compounds released into the environment result in widespread ecosystem contamination. Prominent substances such as polycyclic aromatic hydrocarbons, heavy metal ions, pesticides, fertilizers, and oil derivatives are found in soil, sediment, and water. 
  • 5.0K
  • 07 Sep 2022
Topic Review
Xeno Nucleic Acid
Xeno nucleic acid (XNA) is a synthetic alternative to the natural nucleic acids DNA and RNA as information-storing biopolymers that differs in the sugar backbone. As of 2011, at least six types of synthetic sugars have been shown to form nucleic acid backbones that can store and retrieve genetic information. Research is now being done to create synthetic polymerases to transform XNA. The study of its production and application has created a field known as xenobiology. Although the genetic information is still stored in the four canonical base pairs (unlike other nucleic acid analogues), natural DNA polymerases cannot read and duplicate this information. Thus the genetic information stored in XNA is "invisible" and therefore useless to natural DNA-based organisms.
  • 2.7K
  • 01 Nov 2022
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