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Topic Review
Type I Interferons in Mycobacterium tuberculosis Infection
Tuberculosis (TB) is a leading cause of mortality due to infectious disease and rates have increased during the emergence of COVID-19, but many of the factors determining disease severity and progression remain unclear. Type I Interferons (IFNs) have diverse effector functions that regulate innate and adaptive immunity during infection with microorganisms. 
  • 496
  • 01 Mar 2023
Topic Review
Type I Interferons
Interferons (IFNs) are a heterogenous group of proteins that can be classified into three families (Type I, II, and III) based on distinct functions and characteristics. The family of human type I IFN is composed of 5 subgroups: IFN-α, -β, -κ, -ε, and -ω, whereas the type II IFN group only contains IFN-γ. Type III IFNs are composed of four IFN-λ proteins.
  • 968
  • 06 Mar 2021
Topic Review
Type I Interferon
Together with type III IFNs, Type I Interferons (IFNs-I) represent the first line of immune defense against viral infections. In the case of RNA viruses, after recognition of viral products by pattern recognition receptors (PRRs), such as the main cytosolic receptors RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5), the signal converges on the activation of the mitochondrial antiviral signaling protein (MAVS), that, in turns, activates the TANK-binding kinase 1 (TBK1), leading to the phosphorylation and activation of IFN-regulatory factors 3 and 7 (IRF3, IRF7) [6,7]. IRFs then translocate to the nucleus and induce the production of IFNs-I (IFNα, IFNβ, IFNε, IFNτ, IFNκ, IFNω, IFNδ and IFNζ).
  • 604
  • 07 Sep 2021
Topic Review
Type I IFNs in Long-Haul COVID Syndrome
Interferons (IFNs) are pleiotropic cytokines originally identified for their antiviral activity. IFN-α and IFN-β are both type I IFNs that have been used to treat neurological diseases such as multiple sclerosis. Microglia, astrocytes, as well as neurons in the central and peripheral nervous systems, including spinal cord neurons and dorsal root ganglion neurons, express type I IFN receptors (IFNARs). Type I IFNs play an active role in regulating cognition, aging, depression, and neurodegenerative diseases. Notably, by suppressing neuronal activity and synaptic transmission, IFN-α and IFN-β produced potent analgesia.
  • 755
  • 06 Dec 2022
Topic Review
Type I Diabetes Pathoetiology and Pathophysiology
Type 1 diabetes mellitus (T1DM) arises from the failure of pancreatic β-cells to produce adequate insulin, usually as a consequence of extensive pancreatic β-cell destruction. T1DM is classed as an immune-mediated condition. However, the processes that drive pancreatic β-cell apoptosis remain to be determined, resulting in a failure to prevent ongoing cellular destruction. Alteration in mitochondrial function is clearly the major pathophysiological process underpinning pancreatic β-cell loss in T1DM. This entry highlights the role of intercellular interactions among different cell types in pancreatic islets. It is proposed that the pathoetiology of T1DM arises from mitochondrial interactions among different pancreatic cells, leaving pancreatic B-cells with suppressed capacity to induce the mitochondrial melatonergic pathway, with the associated decrease in pancreatic B-cell melatonin leading to suboptimal mitochondrial function and increased oxidative stress that suppresses PINK1/parkin/mitophagy, leading increased major histocompatibility complex (MHC)-1. This results in the chemoattraction of CD8+ T cells and immune-mediated cell destruction. Variations in different gut bacteria and fungi contribute to pancreatic B-cell loss via their impacts on mitochondrial function within the interacting cells of the pancreatic islets. T1DM may therefore be more of a ‘mitochondria/metabolic’ disorder than an ‘autoimmune’ or ‘immune-mediated’ disorder.
  • 345
  • 15 Feb 2023
Topic Review
Type I Diabetes Mellitus
A considerable endeavor had taken place in order to understand the associated challenges for children and adolescents with Specific Learning Disorder (SLD) and Type 1 Diabetes Mellitus (T1DM) but also in order to describe the necessary skills and approaches that the care givers have to develop to assist both children and parents.
  • 830
  • 14 Feb 2021
Topic Review
Type I Collagen
Type I collagen, the predominant protein of vertebrates, assembles into fibrils that orchestrate the form and function of bone, tendon, skin, and other tissues. Collagen plays roles in hemostasis, wound healing, angiogenesis, and biomineralization, and its dysfunction contributes to fibrosis, atherosclerosis, cancer metastasis, and brittle bone disease.
  • 1.6K
  • 26 Jan 2021
Topic Review
Type I AIE PSs for Antitumor Applications
In modern medicine, precision diagnosis and treatment using optical materials, such as fluorescence/photoacoustic imaging-guided photodynamic therapy (PDT), are becoming increasingly popular. Photosensitizers (PSs) are the most important component of PDT. Different from conventional PSs with planar molecular structures, which are susceptible to quenching effects caused by aggregation, the distinct advantages of AIE (aggregation-induced emission) fluorogens open up new avenues for the development of image-guided PDT with improved treatment accuracy and efficacy in practical applications. PDT has been actively used as a noninvasive treatment in clinical practice for some superficial skin cancers such as skin cancer and bladder cancer.  Although many PSs have been developed for tumor treatment, type II photosensitizers are predominant. Since type II photodynamic therapy is highly oxygen-dependent and its therapeutic effect on anaerobic tumors is inhibited, the development of low oxygen-dependent type I PDT can effectively mitigate this problem.
  • 563
  • 12 Jan 2023
Topic Review
Type Certificate
A type certificate signifies the airworthiness of a particular category of aircraft, according to its manufacturing design (‘type’). It confirms that the aircraft is manufactured according to an approved design, and that the design ensures compliance with airworthiness requirements. For up to three seats, primary category aircraft, certification costs around US$1m, US$25m for a general aviation aircraft and hundreds of millions of dollars for a commercial aircraft; certification delays can cost millions of dollars and can decide a program's profitability.
  • 942
  • 11 Nov 2022
Topic Review
Type C8-class Ship
Type C8-class ships are a type of Heavy Lift Barge Carrier. Type C8 ships were the 8th type of ship designed by the United States Maritime Commission (MARCOM) in the late 1960s. As done with the Type C1 ships and Type C2 ships, MARCOM circulated preliminary plans for comment. The design presented was not specific to any service or trade route. Type C8 ships measuring 876 feet (267 m) from stem to stern, and designed to make 16.2 knots (30.0 km/h; 18.6 mph).
  • 466
  • 17 Oct 2022
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