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Topic Review
UHRF1 in the ECREM Complex
The abnormal DNA methylation profiles are transmitted from the cancer mother cell to the daughter cells through the involvement of a macromolecular complex in which the ubiquitin-like containing plant homeodomain (PHD), and an interesting new gene (RING) finger domains 1 (UHRF1), play the role of conductor. Indeed, UHRF1 interacts with epigenetic writers, such as DNA methyltransferase 1 (DNMT1), histone methyltransferase G9a, erasers like histone deacetylase 1 (HDAC1), and functions as a hub protein. Thus, targeting UHRF1 and/or its partners is a promising strategy for epigenetic cancer therapy. The natural compound thymoquinone (TQ) exhibits anticancer activities by targeting several cellular signaling pathways, including those involving UHRF1.
  • 817
  • 27 May 2021
Topic Review
UGT72
The UDP-glycosyltransferase 72 family (UGT72) of plants has been shown to glycosylate mainly two classes of phenylpropanoids, (i) the monolignols that are the building blocks of lignin, the second most abundant polymer after cellulose, and (ii) the flavonoids, which play determinant roles in plant interactions with other organisms and in response to stress. 
  • 477
  • 01 Apr 2022
Topic Review
UGT1A1 Gene
UDP glucuronosyltransferase family 1 member A1.
  • 460
  • 23 Dec 2020
Topic Review
UFM1
Post-translational modification with Ubiquitin-like proteins represents a complex signaling language regulating virtually every cellular process. Among these post-translational modifiers is Ubiquitin-fold modifier (UFM1), which is covalently attached to its substrates through the orchestrated action of a dedicated enzymatic cascade. Originally identified to be involved embryonic development, its biological function remains enigmatic. Recent research reveals that UFM1 regulates a variety of cellular events ranging from DNA repair to autophagy and ER stress response implicating its involvement in a variety of diseases. Given the contribution of UFM1 to numerous pathologies, the enzymes of the UFM1 cascade represent attractive targets for pharmacological inhibition.
  • 942
  • 26 Feb 2021
Topic Review
Udwadia–Kalaba Equation
In theoretical physics, the Udwadia–Kalaba equation is a method for deriving the equations of motion of a constrained mechanical system. The equation was first described by Firdaus E. Udwadia and Robert E. Kalaba in 1992. The approach is based on Gauss's principle of least constraint. The Udwadia–Kalaba equation applies to both holonomic constraints and nonholonomic constraints, as long as they are linear with respect to the accelerations. The equation generalizes to constraint forces that do not obey D'Alembert's principle.
  • 576
  • 14 Oct 2022
Topic Review
Udvada Atash Behram
The Udvada Atash Behram, also known as the Iran Shah, "King of Iran", is a sacred fire housed in a temple in Udvada, Gujarat on the west coast of India. It is the first of the eight fire temples (holy place of worship) of the Zoroastrian religion in the country. The Atash Bahram, meaning "Victorious Fire", is the oldest fire temples in India, dated to the eight century, and represents the historical cultural and religious links with Iran. The current temple housing the sacred fire was built in 1742 by Motlibai Wadia from Bombay. The temple structure, built spaciously, is well decorated and contains the Dasturji Koyaji Mirza hall and a museum. The main hall of the temple is accessed through a two-stage staircase. The temple attracts Zoroastrian pilgrims from all parts of India, Pakistan and from around the world.
  • 846
  • 07 Nov 2022
Topic Review
UDP-Glucuronosyltransferase Genetic and Drug Responses
UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many prescription drugs, such as opioids, antiepileptics, and antiviral drugs. The UGT1A and 2B genes are highly polymorphic, and their genetic variants may affect the pharmacokinetics and hence the responses of many drugs and fatty acids.
  • 617
  • 07 Jul 2021
Topic Review
UDOO
UDOO is a single-board computer with an integrated Arduino Due compatible microcontroller, designed for computer science education, the world of Makers and the Internet of Things. The product was launched on Kickstarter in April 2013, reaching wide consensus. "The product line involves three single board computers – UDOO QUAD/DUAL (2013), UDOO NEO (2015), UDOO X86 (2016) – that differ over various aspects, plus the UDOO BLU and the set of UDOO BRICKS." UDOO is a development platform that merges a Dual or Quad Core ARM Freescale Cortex-A9 i.MX 6 CPU, that can run Linux or Android operating systems, and an Arduino Due compatible board with a dedicated ARM Atmel SAM3X8E CPU. UDOO is a joint effort of AIDILAB srl and SECO USA Inc, from an idea of Antonio Rizzo, Maurizio Caporali and Daniele Conti, born in collaboration with a multidisciplinary team of researchers with expertise in interaction design, embedded systems, sensor networks and cognitive science.
  • 652
  • 31 Oct 2022
Biography
Udhayakumar Kaithamalai
Dr. Udhayakumar Kaithamalai is working as professor in the Department of Electrical and Electronics Engineering, College of Engineering Guindy, Anna University, Chennai, India. Beginning in August 2001, he has held positions at this University in a variety of capacities including Teaching & Research Associate, Lecturer, Senior Lecturer, Assistant Professor, Associate Professor and Professor (cur
  • 625
  • 21 Dec 2022
Topic Review
Udall Family
The Udall family is a U.S. political family rooted in the American West. Its role in politics spans over 100 years and four generations. Udall politicians have been elected from four different states: Arizona, Colorado, New Mexico, and Oregon. If viewed as a combined entity, the Udall-Hunt-Lee family has been elected from six states: Arizona, California, Colorado, New Mexico, Oregon, and Utah. Three Udall family cousins were nominated by the two major American political parties for the United States Senate elections of 2008, of which the two Democrats were elected and seated in 2009.
  • 545
  • 25 Nov 2022
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