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Topic Review
Unfolded Protein Response in Ischemic Stroke
Many pathologic states can lead to the accumulation of unfolded/misfolded proteins in cells. This causes endoplasmic reticulum (ER) stress and triggers the unfolded protein response (UPR), which encompasses three main adaptive branches. One of these UPR branches is mediated by protein kinase RNA-like ER kinase (PERK), an ER stress sensor. The primary consequence of PERK activation is the suppression of global protein synthesis, which reduces ER workload and facilitates the recovery of ER function. Ischemic stroke induces ER stress and activates the UPR. 
  • 136
  • 15 Mar 2024
Topic Review
Unfolded Protein Response and CD
Endoplasmic reticulum (ER) stress triggers a series of signaling and transcriptional events termed the unfolded protein response (UPR). Severe ER stress is associated with the development of fibrosis in different organs, including lung, liver, kidney, heart, and intestine. ER stress is an essential response of epithelial and immune cells in the pathogenesis of Inflammatory Bowel Disease (IBD), including Crohn’s disease (CD). Intestinal epithelial cells are susceptible to ER stress-mediated damage due to secretion of a large amount of proteins that are involved in mucosal defense. In other cells, ER stress is linked to myofibroblast activation, extracellular matrix production, macrophage polarization, and immune cell differentiation.
  • 585
  • 07 May 2021
Topic Review
Unfired Clay Bricks
Bricks are typically made through the high-temperature firing process or by stabilizing the mixture with binders such as lime and cement. These bricks have a large carbon footprint and high levels of grey energy. In many parts of the world, the excessive use of clay as a natural raw material for the production of conventional bricks will lead to its scarcity. The mixing of clay with lignocellulosic ash during brick manufacturing leads to a better and more reliable solution that conserves scarce natural resources and reduces the impact of environmental pollution. 
  • 1.6K
  • 31 Oct 2022
Topic Review
Unexpected Role of MPO-Oxidized LDLs in Atherosclerosis
Inflammation and its resolution are the result of the balance between pro-inflammatory and pro-resolving factors, such as specialized pro-resolving mediators (SPMs). This balance is crucial for plaque evolution in atherosclerosis, a chronic inflammatory disease. Myeloperoxidase (MPO) has been related to oxidative stress and atherosclerosis, and MPO-oxidized low-density lipoproteins (Mox-LDLs) have specific characteristics and effects. They participate in foam cell formation and cause specific reactions when interacting with macrophages and endothelial cells. They also increase the production of intracellular reactive oxygen species (ROS) in macrophages and the resulting antioxidant response. Mox-LDLs also drive macrophage polarization. Mox-LDLs are known to be pro-inflammatory particles. However, in the presence of Mox-LDLs, endothelial cells produce resolvin D1 (RvD1), a SPM. SPMs are involved in the resolution of inflammation by stimulating efferocytosis and by reducing the adhesion and recruitment of neutrophils and monocytes. RvD1 also induces the synthesis of other SPMs. In vitro, Mox-LDLs have a dual effect by promoting RvD1 release and inducing a more anti-inflammatory phenotype macrophage, thereby having a mixed effect on inflammation.
  • 442
  • 23 Jun 2022
Topic Review
Unethical Role of Artificial Intelligence in Scholarly Writing
The emergence of artificial intelligence (AI) has greatly propelled progress across various sectors including the field of nephrology academia. However, this advancement has also given rise to ethical challenges, notably in scholarly writing. AI’s capacity to automate labor-intensive tasks like literature reviews and data analysis has created opportunities for unethical practices, with scholars incorporating AI-generated text into their manuscripts, potentially undermining academic integrity. 
  • 510
  • 05 Jan 2024
Topic Review
Unethical Organizational Behaviors for the Sake of Family
Job loss and job insecurity were among the topics that were of most concern as consequences of the worldwide spread of the coronavirus. Export-dependent economies and economies that rely on tourism have struggled adjusting to fluctuating and shifting demand. The World Travel and Tourism Council (WTTC) suggested that the global job market was at risk for 75 million people in 2020, while the World Economic Forum reported that the lockdown and layoff practices during the COVID-19 pandemic resulted in 114 million job losses in 2020. Even employees who survive the layoffs become anxious about their career and suffer high levels of job insecurity. Financial stress on the family (i.e., related to satisfying basic needs, family education cost, utilities payments, or family healthcare expenses) is likely to exacerbate job insecurity, which in turn leads to financial pressure. 
  • 880
  • 10 Jun 2022
Topic Review
UNet and Conventional DL Systems for CAD
The ability of UNet-based deep learning models as shown before is very powerful in the imaging domain and can handle image noise, structure, scale, size, resolution, and further, the variability in the shapes.
  • 132
  • 22 Dec 2023
Topic Review
Unemployment Benefits
Unemployment benefits (depending on the jurisdiction also called unemployment insurance or unemployment compensation) are payments made by back authorized bodies to unemployed people. In the United States, benefits are funded by a compulsory governmental insurance system, not taxes on individual citizens. Depending on the jurisdiction and the status of the person, those sums may be small, covering only basic needs, or may compensate the lost time proportionally to the previous earned salary. Unemployment benefits are generally given only to those registering as unemployed, and often on conditions ensuring that they seek work and do not currently have a job, and are validated as being laid off and not fired for cause in most states.
  • 543
  • 11 Nov 2022
Topic Review
Undue Influence
Undue influence (UI) is a psychological process by which a person's free will is supplanted by that of another. It is a legal term and the strict definition varies by jurisdiction. Generally speaking, it is a means by which a person gains control over their victim's decision making through tactics and unfair pressure, typically for financial gain. Historically, UI has been poorly understood, even in legal circles. Undue influence occurs behind closed doors and there are often no witnesses. UI is typically perpetrated by a person trusted by the victim and is dependent on them for emotional and physical needs. Anyone may be guilty of undue influence and is often a paid or unpaid caregiver, but may also be an attorney, accountant, nursing home attendant, neighbor, or even the victims' children. Undue influence is a process, not a single event; the influencer may spend weeks, months, or even years "grooming" and manipulating their victim. Anyone is susceptible to undue influence, but the elderly are particularly vulnerable. A distinction is made between the nature of capacity and undue influence. In assessing capacity, the practitioner evaluates an individual's ability to competently perform tasks (e.g., execute a will or give medical consent). These assessments give insight to the functioning of the cognitive capabilities at that moment in time. Conversely, screening for undue influence is focused on the process of events which occur over an extended period. To determine whether another person is leveraging unfair tactics on the victim, an assessment particular to undue influence is required. Undue influence occurs in various circumstances including: domestic violence, hostage situations, cults, prisoners of war, and dictatorships. The common theme among these situations is the aspect of psychological manipulation. Traumatic bonding occurs between the victim and the influencer, as a result, victims are unaware they're being manipulated and will often defend the perpetrator. Gaining independence from the influencer is required if the victim is to recover from the effects of UI, much like victim's of Stockholm syndrome, cults, and kidnapping. The effectiveness of cult tactics on young and healthy individuals illustrates that anyone, regardless of mental status, is a potential victim of UI under certain circumstances. Elderly Americans are living longer, and with this increased life expectancy, the prevalence of cognitive disorders associated with advanced age has also increased. A significant concentration of wealth is controlled by this aging demographic. As modern families become more complex and dispersed, and people are living longer, the likelihood of will contests involving undue influence is expected to increase.
  • 711
  • 18 Oct 2022
Topic Review
Underwater Wireless Sensor Networks
The underwater wireless sensor network (UWSN) is a network used to perform monitoring of tasks over a specific region; it is equipped with smart sensors and vehicles that are adapted to communicate cooperatively through wireless connections [1]. The surface sink retrieves the data from sensor nodes. The sink node has a transceiver that can control acoustic signals received from underwater nodes. The transceiver also can transmit and receive long-range radio frequency signals for communication with the onshore station. The collected data are used locally or connected to another network for a particular purpose [2].
  • 9.4K
  • 26 Oct 2020
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