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Topic Review
Peculiarities of Tumor Cell Metabolism for Cancer Treatment
In tumor cells, ketolysis “via” succinyl-CoA: 3-oxoacid-CoAtransferase (SCOT) and acetyl-CoA acetyltransferase 1 (ACAT1) is a major source of mitochondrial acetyl-CoA. Active ACAT1 tetramers stabilize by tyrosine phosphorylation, which facilitates the SCOT reaction and ketolysis. Tyrosine phosphorylation of pyruvate kinase PK M2 has the opposite effect, stabilizing inactive dimers, while pyruvate dehydrogenase (PDH), which is already inhibited by phosphorylation, is acetylated by ACAT1 and is doubly locked. This closes the glycolytic supply of acetyl-CoA. In addition, since tumor cells must synthesize fatty acids to create new membranes, they automatically turn off the degradation of fatty acids into acetyl-CoA (“via” the malonyl-CoA brake for the fatty acid carnityl transporter). Thus, inhibiting SCOT the specific ketolytic enzyme and ACAT1 should hold back tumor progression. However, tumor cells are still able to take up external acetate and convert it into acetyl-CoA in their cytosol “via” an acetyl-CoA synthetase, which feeds the lipogenic pathway; additionally, inhibiting this enzyme would make it difficult for tumor cells to form new lipid membrane and survive.
  • 6.9K
  • 21 Feb 2023
Topic Review
Blonde Stereotype
Blonde stereotypes are stereotypes of blond-haired women. Sub-types include the "blonde bombshell" and the "dumb blonde". Blondes are differently stereotyped from brunettes as more desirable and less intelligent. There are many blonde jokes made on these premises. Although chiefly aimed at women, jokes of this style have also been aimed at similar stereotypes associated with men, such as the "dumb jock" and the "surfer dude".
  • 6.9K
  • 25 Oct 2022
Topic Review
Artificial Intelligence in Education (AIED)
Artificial Intelligence in Education (AIED) has 3 meanings : The first is “education for understanding AI,” which aims to develop the ability to understand and handle AI. The second is “education using AI,” which applies AI to effective teaching and learning in each subject. The third is “AI expert training,” which cultivates experts who develop AI and teachers who teach AI.
  • 6.9K
  • 27 Jul 2021
Topic Review
HepG2 Cell Line
HepG2 is a hepatoblastoma cell line. It is used in a wide range of studies: a model of hepatoblastoma (HB) and hepatocellular carcinoma (HCC), cytotoxicity testing and the identification of drug metabolic pathways on the liver. 
  • 6.9K
  • 20 Dec 2021
Topic Review
Early World Maps
The earliest known world maps date to classical antiquity, the oldest examples of the 6th to 5th centuries BCE still based on the flat Earth paradigm. World maps assuming a spherical Earth first appear in the Hellenistic period. The developments of Greek geography during this time, notably by Eratosthenes and Posidonius culminated in the Roman era, with Ptolemy's world map (2nd century CE), which would remain authoritative throughout the Middle Ages. Since Ptolemy, knowledge of the approximate size of the globe allowed cartographers to estimate the extent of their geographical knowledge, and to indicate parts of the globe known to exist but not yet explored as terra incognita. With the Age of Discovery, during the 15th to 18th centuries, world maps became increasingly accurate; exploration of Antarctica and the interior of Africa by western mapmakers was left to the 19th and early 20th century.
  • 6.9K
  • 28 Oct 2022
Topic Review
Seed Morphology
Seed morphology is the scientific analysis and description of the shape of seeds.
  • 6.9K
  • 28 Oct 2020
Topic Review
Smart Cities
"Smart cities" are a new type of city where stakeholders are jointly responsible for urban management. City Information Management (CIM) is an output tool for smart city planning and management, which assists in achieving the sustainable development of urban infrastructure, and promotes smart cities to achieve the goals of stable global economic development, sustainable environmental development, and improvement of people’s quality of life. Existing research has so far established that blockchain and BIM have great potential to enhance construction project performance.
  • 6.9K
  • 14 Mar 2021
Topic Review
Chemical Affinity
In chemical physics and physical chemistry, chemical affinity is the electronic property by which dissimilar chemical species are capable of forming chemical compounds. Chemical affinity can also refer to the tendency of an atom or compound to combine by chemical reaction with atoms or compounds of unlike composition.
  • 6.9K
  • 20 Oct 2022
Topic Review
Greenhouse Drying System
Drying via solar energy is an environmentally friendly and inexpensive process. For controlled and bulk level drying, a greenhouse solar dryer is the most suitable controlled level solar dryer. The efficiency of a solar greenhouse dryer can be increased by using thermal storage. The agricultural products dried in greenhouses are reported to be of a higher quality than those dried in the sun because they are shielded from dust, rain, insects, birds, and animals. The heat storage-based greenhouse was found to be superior for drying of all types of crops in comparison to a normal greenhouse dryer, as it provides constant heat throughout the drying process.
  • 6.8K
  • 30 Jan 2023
Topic Review
The Hook
The Hook, or The Hookman, is an urban legend about a killer with a pirate-like hook for a hand attacking a couple in a parked car. The story is thought to date from at least the mid-1950s, and gained significant attention when it was reprinted in the advice column Dear Abby in 1960. It has since become a morality archetype in popular culture, and has been referenced in various horror films.
  • 6.8K
  • 03 Mar 2023
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