Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
P53 Protein famliy
p53 and p73 are critical tumor suppressors that are often inactivated in human cancers through various mechanisms. Owing to their high structural homology, the proteins have many joined functions and recognize the same set of genes involved in apoptosis and cell cycle regulation. p53 is known as the ‘guardian of the genome’ and together with p73 forms a barrier against cancer development and progression. The TP53 is mutated in more than 50% of all human cancers and the germline mutations in TP53 predispose to the early onset of multiple tumors in Li–Fraumeni syndrome (LFS), the inherited cancer predisposition. In cancers where TP53 gene is intact, p53 is degraded. Despite the ongoing efforts, the treatment of cancers remains challenging. Presently, the endeavors focus on reactivating p53 exclusively, neglecting the potential of the restoration of p73 protein for cancer eradication. Taken that several small molecules reactivating p53 failed in clinical trials, there is a need to develop new treatments targeting p53 proteins in cancer. This review outlines the most advanced strategies to reactivate p53 and p73 and describes drug repurposing approaches for the efficient reinstatement of the p53 proteins for cancer therapy.
  • 2.9K
  • 21 Oct 2020
Topic Review
Electrical Conductivity of Nanoparticle-Enhanced Fluids
Research on nanoparticle-enhanced fluids’ electrical conductivity is at its beginning at this moment and the augmentation mechanisms are not fully understood. Basically, the mechanisms for increasing the electrical conductivity are described as electric double layer influence and increased particles’ conductance. Another idea that has resulted from state of the art is that the stability of nanofluids can be described with the help of electrical conductivity tests, but more coordinated research is needed. Concluding, this analysis has shown that a lot of research work is needed in the field of nanofluids’ electrical characterization and specific applications.
  • 2.9K
  • 23 Oct 2020
Topic Review
Impact of Automobility on Urban Sprawl
Urban sprawl has become a controversial issue. Lines of thought among academics, practitioners, and local authorities have been diverse. Some academics advocate the compact city as an antidote to urban sprawl, some scholars doubt the ability of conventional notions of containments to create sustainability, and others are fascinated by urban technologies and believe in the feasibility of these technologies, whereas local authorities impose policies, one after the other, without effective results.
  • 2.9K
  • 29 Sep 2022
Topic Review
Urban Wastewater Treatment in Greece
Although Greece has accomplished the wastewater infrastructure construction in a large extent, as 91% of the country’s population is already connected to urban wastewater treatment plants (WWTPs), many problems still need to be faced, such as the limited reuse of treated wastewater and of the surplus sludge (biosolids) produced, the relative higher energy consumption in the existing rather aged WWTPs infrastructure and the proper management of failing or inadequately designed septic tank/soil absorption systems, still in use in several (mostly rural) areas, lacking sewerage systems. Moreover, the wastewater treatment sector should be examined in the general framework of sustainable environmental development; therefore, Greece’s future challenges in this sector ought to be reconsidered. Thus, the review of Greece’s urban wastewater history, even from the ancient times, up to current developments and trends, will be shortly addressed. Noting also that the remaining challenges should be analyzed in respect to the country’s specific needs (e.g. interaction with the extensive tourism sector), as well as to the European Union’s relevant framework policies and to the respective international technological trends, aiming to consider the wastewater treatment plants (WWTPs) not only as sites for the treatment/removal of pollutants to prevent environmental pollution, but also as industrial places where energy is efficiently used (or even produced), resources’ content can be potentially recovered and reused (e.g. nutrients, treated water, biosolids) and the environmental sustainability is being overall practiced.
  • 2.9K
  • 04 Aug 2020
Topic Review
Sinhapura
Sinhapura (Sanskrit, "Lion City"; IAST: Siṃhapura) was the capital of the legendary Indian king Sinhabahu. It has been mentioned in the Buddhist legends about Prince Vijaya. The name is also transliterated as Sihapura or Singhapura. The location of Sinhapura is disputed with some scholars claiming the city was located in eastern India and others claiming it was located in present-day Malaysia or Thailand. The city is linked to the origin of the Sinhalese people and Sinhalese Buddhist mythology.
  • 2.9K
  • 27 Oct 2022
Topic Review
Interferometry
Interferometry is a family of techniques in which waves, usually electromagnetic waves, are superimposed causing the phenomenon of interference in order to extract information. Interferometry is an important investigative technique in the fields of astronomy, fiber optics, engineering metrology, optical metrology, oceanography, seismology, spectroscopy (and its applications to chemistry), quantum mechanics, nuclear and particle physics, plasma physics, remote sensing, biomolecular interactions, surface profiling, microfluidics, mechanical stress/strain measurement, velocimetry, and optometry.:1–2 Interferometers are widely used in science and industry for the measurement of small displacements, refractive index changes and surface irregularities. In most interferometers, light from a single source is split into two beams that travel different optical paths, then combined again to produce interference, however, under the some circumstances two incoherent sources can also be interfered. The resulting interference fringes give information about the difference in optical path length. In analytical science, interferometers are used to measure lengths and the shape of optical components with nanometer precision; they are the highest precision length measuring instruments existing. In Fourier transform spectroscopy they are used to analyze light containing features of absorption or emission associated with a substance or mixture. An astronomical interferometer consists of two or more separate telescopes that combine their signals, offering a resolution equivalent to that of a telescope of diameter equal to the largest separation between its individual elements.
  • 2.9K
  • 17 Nov 2022
Topic Review
Glossary of Bird Terms
The following is a glossary of common English language terms used in the description of birds—warm-blooded vertebrates of the class Aves and the only living dinosaurs, characterized by feathers, the ability to fly in all but the approximately 60 extant species of flightless birds, toothless, beaked jaws, the laying of hard-shelled eggs, a high metabolic rate, a four-chambered heart and a strong yet lightweight skeleton. Among other details such as size, proportions and shape, terms defining bird features developed and are used to describe features unique to the class—especially evolutionary adaptations that developed to aid flight. There are, for example, numerous terms describing the complex structural makeup of feathers (e.g., barbules, rachides and vanes); types of feathers (e.g., filoplume, pennaceous and plumulaceous feathers); and their growth and loss (e.g., colour morph, nuptial plumage and pterylosis). There are thousands of terms that are unique to the study of birds. This glossary makes no attempt to cover them all, concentrating on terms that might be found across descriptions of multiple bird species by bird enthusiasts and ornithologists. Though words that are not unique to birds are also covered, such as "back" or "belly", they are defined in relation to other unique features of external bird anatomy, sometimes called "topography". As a rule, this glossary does not contain individual entries on any of the approximately 9,700 recognized living individual bird species of the world.
  • 2.9K
  • 09 Nov 2022
Topic Review
Augmented Humanity
Augmented humanity is a human–computer integration technology that proposes to improve capacity and productivity by changing or increasing the normal ranges of human function, through the restoration or extension of human physical, intellectual and social capabilities.
  • 2.9K
  • 07 Feb 2022
Topic Review
Dromomania
Dromomania was a historical psychiatric diagnosis whose primary symptom was uncontrollable urge to walk or wander. Dromomania has also been referred to as travelling fugue. Non-clinically, the term has come to be used to describe a desire for frequent traveling or wanderlust.
  • 2.9K
  • 01 Nov 2022
Topic Review
2020 Twitter Bitcoin Scam
User:RMCD bot/subject notice On July 15, 2020, between 20:00 and 22:00 UTC, around 130 high-profile Twitter accounts were compromised by outside parties to promote a bitcoin scam. Twitter and other media sources confirmed that the perpetrators had gained access to Twitter's administrative tools so that they could alter the accounts themselves and post the tweets directly. They appeared to have used social engineering to gain access to the tools via Twitter employees. The scam tweets asked individuals to send bitcoin currency to a specific cryptocurrency wallet, with the promise of the Twitter user that money sent would be doubled and returned as a charitable gesture. Within minutes from the initial tweets, more than 320 transactions had already taken place on one of the wallet addresses, and more than US$110,000 of equivalent bitcoin had been deposited in one account before the scam messages were removed by Twitter. In addition, full message history data from eight non-verified accounts was also acquired. Dmitri Alperovitch, the co-founder of cybersecurity company CrowdStrike, described the incident as "the worst hack of a major social media platform yet." The FBI and other law enforcement agencies are investigating the scam and the security used by Twitter. Security researchers expressed concerns that the social engineering used to execute the hack can affect the use of social media in important online discussions, including the lead-up into the 2020 United States presidential election.
  • 2.9K
  • 17 Nov 2022
  • Page
  • of
  • 5361
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback