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Topic Review
Bagging on Fruit Quality
Fruit bagging consists essentially of enclosing a young fruit in a food bag by capping the bag with a ribbon or a clamp on the fruit stalk. Isolating the fruit from the external environment protects it during development from mechanical or biotic damage, especially in regions where fruits are prone to attacks by fungi, bacteria, insects and even birds.
  • 4.4K
  • 18 Mar 2021
Topic Review
Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (P-ANCA)
Perinuclear anti-neutrophilic cytoplasmic antibodies (P-ANCA) recognize heterogeneous antigens, including myeloperoxidase (MPO), lactoferrin, elastase, cathepsin-G and bactericidal/permeability-increasing protein. Although P-ANCA have diagnostic utility in vasculitides, they may also be found in patients with various other systemic autoimmune rheumatic diseases (SARDs). Nevertheless, the clinical significance and the targets recognized by P-ANCA in such patients remain unclear. For this purpose, herein we investigated the occurrence of ANCA-related antigenic specificities in 82 P-ANCA-positive sera by multiplex ELISA, as well as their association with other autoantibodies. The P-ANCA-positive sera corresponded to patients with vasculitides (n = 24), systemic lupus erythematosus (n = 28), antiphospholipid syndrome (n = 5), Sjögren’s syndrome (n = 7), rheumatoid arthritis (n = 3), systemic scleroderma (n = 1), sarcoidosis (n = 1) and Hashimoto′s thyroiditis (n = 13). In most P-ANCA-positive patients studied (51/82, 62.3%), these autoantibodies occurred in high titers (>1:160). The analysis of P-ANCA-positive sera revealed reactivity to MPO in only 50% of patients with vasculitides, whereas it was infrequent in the other disease groups studied. Reactivity to other P-ANCA-related autoantigens was also rarely detected. Our findings support that high P-ANCA titers occur in SARD. The P-ANCA-positive staining pattern is associated with MPO specificity in vasculitides, while in other autoimmune diseases, it mostly involves unknown autoantigens. 
  • 4.4K
  • 27 Aug 2021
Topic Review
Stall (Fluid Mechanics)
In fluid dynamics, a stall is a reduction in the lift coefficient generated by a foil as angle of attack increases. This occurs when the critical angle of attack of the foil is exceeded. The critical angle of attack is typically about 15 degrees, but it may vary significantly depending on the fluid, foil, and Reynolds number. Stalls in fixed-wing flight are often experienced as a sudden reduction in lift as the pilot increases the wing's angle of attack and exceeds its critical angle of attack (which may be due to slowing down below stall speed in level flight). A stall does not mean that the engine(s) have stopped working, or that the aircraft has stopped moving—the effect is the same even in an unpowered glider aircraft. Vectored thrust in manned and unmanned aircraft is used to surpass the stall limit, thereby giving rise to post-stall technology. Because stalls are most commonly discussed in connection with aviation, this article discusses stalls as they relate mainly to aircraft, in particular fixed-wing aircraft. The principles of stall discussed here translate to foils in other fluids as well.
  • 4.4K
  • 16 Nov 2022
Topic Review
Small and Medium Enterprises (SMEs) Performance
SMEs are one of the business entities that make a significant contribution to economic conditions in Indonesia. This is the reason why information about the condition and presence of SMEs is important data for the government as an indicator for Indonesia’s economic conditions, especially during the COVID-19 pandemic. 
  • 4.4K
  • 23 May 2022
Topic Review
NAFLD and Cardiovascular Comorbidities
Non-alcoholic fatty liver disease (NAFLD) is a liver disease that can progress from hepatic steatosis to steatohepatitis and even cirrhosis and hepatocellular carcinoma. From the histopathological point of view, it is characterized by excess storage of macrovesicular fat in hepatocytes. These macrovesicular storages are composed of triglycerides that accumulate in the liver. The process can lead in some individuals to an inflammatory response, which is responsible for steatohepatitis, that leads to fibrosis and, finally, cirrhosis.NAFLD has a growing prevalence in recent years. Its association with cardiovascular disease has been intensively studied, and certain correlations have been identified. The connection between these two entities has lately aroused interest regarding therapeutic management. 
  • 4.4K
  • 07 May 2021
Topic Review
Magellan's Circumnavigation
In 1519, the Portuguese naval officer and explorer Ferdinand Magellan led a Spanish expedition to find a western route to the East Indies and reach the Moluccas or Spice Islands (in present day Indonesia) with a fleet known as the Armada de Molucca. After the death of Magellan in the Philippines in 1521 and following several other short-lived leaderships, Spanish navigator Juan Sebastián Elcano led the expedition to the Spice Islands and ultimately across the Indian Ocean and up the Atlantic ocean back to Spain, resulting in the first circumnavigation of the world in 1522. The expedition is therefore also known as the Magellan–Elcano circumnavigation. The goal of the expedition was to find a western route to the Moluccas (Spice Islands) and trade for spices. Magellan left Spain on 20 September 1519, sailed across the Atlantic, and discovered the strait that now bears his name, allowing him to pass through the southern tip of South America into the Pacific Ocean (which he named). The fleet performed the first ever crossing of the Pacific, stopping in what is today called the Philippines , and eventually reached the Moluccas, accomplishing its goal. A much-depleted crew finally returned to Spain on 6 September 1522. The fleet initially consisted of about 270 men and five ships: four carracks and one caravel. The expedition faced numerous hardships including mutinies, starvation, scurvy, storms, and hostile encounters with indigenous people. Magellan died in battle in the Philippine islands and was succeeded as captain-general by a series of officers, with Juan Sebastián Elcano leading the trip onward to Spain. He and seventeen other men in one ship (the Victoria) were the only ones to circumnavigate the globe. The expedition was funded mostly by King Charles I of Spain, with the hope that it would discover a profitable western route to the Moluccas, as the eastern route was controlled by Portugal under the Treaty of Tordesillas. Though the expedition did find a route, it was much longer and more arduous than expected, and was therefore not commercially useful. Nevertheless, the first circumnavigation has been regarded as a great achievement in seamanship, and had a significant impact on the European understanding of the world.
  • 4.4K
  • 16 Nov 2022
Topic Review Peer Reviewed
Ferdinand II of Aragon (1479–1516)
Ferdinand II king of Aragon (1479–1516). He was the fourth king of the Trastámara dynasty, which had first come to power after the Compromise of Caspe, reached after Martin I died with no living descendants in 1410. Although in terms of artistic patronage Ferdinand II was not as active as his wife Elisabeth I, he was still aware that the wise use of artistic commissions in reinforcing ideas and concepts favourable to the institution of the monarchy. He is a highly important figure in the history of Spain because, along with Elisabeth, he was one of the Catholic Monarchs and thus represents a new conception of power based on their joint governance, a fact that is reflected in the iconography found in his artistic commissions across all genres. All of the images are evidence of how King Ferdinand, at the end of the Middle Ages, wanted to be recognised by his subjects, who also used his image for legitimising and propagandistic purposes. Nobody else in the history of the Hispanic kingdoms had their image represented so many times and on such diverse occasions as did the Catholic Monarchs.
  • 4.3K
  • 13 Apr 2022
Topic Review
Sex Ratio
The sex ratio is the ratio of males to females in a population. In most sexually reproducing species, the ratio tends to be 1:1. This tendency is explained by Fisher's principle. For various reasons, however, many species deviate from anything like an even sex ratio, either periodically or permanently. Examples include parthenogenic species, periodically mating organisms such as aphids, some eusocial wasps such as Polistes fuscatus and Polistes exclamans, bees, ants, and termites. The human sex ratio is of particular interest to anthropologists and demographers. In human societies, however, sex ratios at birth may be considerably skewed by factors such as the age of mother at birth, and by sex-selective abortion and infanticide. Exposure to pesticides and other environmental contaminants may be a significant contributing factor as well. As of 2014, the global sex ratio at birth is estimated at 107 boys to 100 girls (1,000 boys per 934 girls).
  • 4.4K
  • 19 Oct 2022
Topic Review
Ex Nihilo
Ex nihilo is Latin for "out of nothing": when phrased as ex nihilo nihil fit, "nothing comes from nothing", it means that the universe was formed from eternal matter; as creatio ex nihilo, "creation out of nothing", it means that matter is not eternal but had to be created by some eternal uncaused cause, frequently defined as God. Creation ex nihilo is a theistic answer to the question of how the universe comes to exist: the Big Bang theory, by contrast, is a scientific theory; it offers no explanation of cosmic existence but only a description of the first few moments of that existence.
  • 4.4K
  • 28 Sep 2022
Topic Review
Phenolic Acids
Phenolic acids comprise a class of phytochemical compounds that can be extracted from various plant sources and are well known for their antioxidant and anti-inflammatory properties.
  • 4.4K
  • 26 Sep 2021
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