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Topic Review
Myeloid Differentiation 88 (MyD88)
Myeloid differentiation 88 (MyD88) is a well-established inflammatory adaptor protein.
  • 259
  • 05 May 2021
Topic Review
NaDES Application in Cosmetic and Pharmaceutical Fields
Natural deep eutectic solvents (NaDES) represent a new generation of green, non-flammable solvents, useful as an efficient alternative to the well-known ionic liquids. They can be easily prepared and exhibit unexpected solubilizing power for lipophilic molecules, although those of a hydrophilic nature are mostly used. For their unique properties, they can be recommend for different cosmetic and pharmaceutical applications, ranging from sustainable extraction, obtaining ready-to-use ingredients, to the development of biocompatible drug delivery responsive systems. 
  • 142
  • 01 Feb 2024
Topic Review
Nano and Microemulsions for Depression and Anxiety Treatment
Most drugs used for the treatment of depression, anxiety and related disorders have low absorption, high metabolism, low brain targeting and/or low water solubility, which can make it hard to formulate them at high strength and can also lead to decreased bioavailability. Incorporating these drugs into nanometric emulsions can solve these issues. Nanometric emulsions were able to increase drug strength up to 20,270-fold (compared to aqueous solubility). The formulations showed droplet size, polydispersity index, zeta potential, viscosity, osmolality, pH, in vitro drug release and ex vivo drug permeation as adequate for the intended effect and administration route.
  • 558
  • 23 Dec 2022
Topic Review
Nano-Drug Delivery Systems Targeting Colorectal Cancer
Colorectal cancer (CRC) is a usual digestive tract malignancy and the third main cause of cancer death around the world, with a high occurrence rate and mortality rate. Conventional therapies for CRC have certain side effects and restrictions. However, the exciting thing is that with the rapid development of nanotechnology, nanoparticles have gradually become more valuable drug delivery systems than traditional therapies because of their capacity to control drug release and target CRC. This also promotes the application of nano-drug targeted delivery systems in the therapy of CRC.
  • 810
  • 24 May 2022
Topic Review
Nano-Formulations for Pulmonary Delivery
With the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol lung deposition rates, and increasing drug bioavailability. They are expected to solve the difficulties faced in treating lung diseases. 
  • 126
  • 07 Feb 2024
Topic Review
Nano-Gels in Skin Cancer
Nano-gels, a dual combination of hydrogels and nanoparticles, have demonstrated significant promise as a targeted drug delivery system in the treatment of cancer, attributing to excellent drug loading capacity. Skin disorders, the 4th foremost source of non-fatal diseases, are frequently the outward manifestation of more serious systemic illnesses, such as HIV, and neglected tropical diseases, such as elephantiasis and other ailments causing lymphedema.
  • 471
  • 27 Apr 2023
Topic Review
Nanocarriers in Enhanced Antifungal Delivery
Fungal infections are an extremely serious health problem, particularly in patients with compromised immune systems. Most antifungal agents have low aqueous solubility, which may hamper their bioavailability. Their complexation with cyclodextrins (CDs) could increase the solubility of antifungals, facilitating their antifungal efficacy. Nanoparticulate systems are promising carriers for antifungal delivery due to their ability to overcome the drawbacks of conventional dosage forms. CD-based nanocarriers could form beneficial combinations of CDs and nanoparticulate platforms. These systems have synergistic or additive effects regarding improved drug loading, enhanced chemical stability, and enhanced drug permeation through membranes, thereby increasing the bioavailability of drugs. 
  • 666
  • 08 Dec 2022
Topic Review
Nanodelivery Systems and Constituents Derived from Novel Foods
Novel Food is a new category of food, regulated by the European Union Directive No. 2015/2283. This latter norm defines a food as “Novel” if it was not used “for human consumption to a significant degree within the Union before the date of entry into force of that regulation, namely 15 May 1997”.  Due to their natural source, Novel Food can represent another new and not fully exploited reservoir of nutraceuticals. Indeed, Novel Food can also be considered an important source of raw matter to produce a nano-drug delivery system. The application of Novel Foods as new nanoceutical materials or bioactive compounds embedded into nanocarriers is a new research field, as these sources have been employed only in recent decades.
  • 103
  • 17 Nov 2023
Topic Review
Nanodelivery Systems for Herbal/Phytoconstituents
Herbs and spices have been historically characterized as plant components utilized in the diet for their fragrant characteristics, but have no or minimal nutritional value. Herbs and spices, on the other hand, have been found as sources of different phytochemicals with strong antioxidant activity. As a result, phytoconstituents from herbs and spices can be formulated in various forms of nano-drug delivery systems.
  • 563
  • 29 Dec 2022
Topic Review
Nanoemulsion in Management of Colorectal Cancer
The second most significant cause of cancer-related mortality and morbidity in the United States is colorectal cancer (CRC), the third most diagnosed malignancy. People over 50 have an increased risk of CRC everywhere in the world. Genetic and environmental risk factors significantly influence CRC development. Early detection is critical in the treatment and prevention of CRC. The population’s incidence rate of CRC is reduced by screening techniques and medicines, although recurrence of the disease may result from the cancer’s ability to spread locally. Nanotechnology is crucial for cancer treatment because it allows for the delivery of targeted chemotherapies to cancer cells directly and with greater therapeutic potency. Nanoemulsions have broad application in pharmaceutics, cosmetics, and food; their outstanding properties include enhanced dispersion of active hydrophobic components, small size, high surface area per unit volume, and improved absorption in cancer treatment.
  • 209
  • 14 Aug 2023
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