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All Topic Review Biography
Topic Review
Disparities in Prevalence and Barriers to Hypertension Control
Controlling hypertension (HTN) remains a challenge, as it is affected by various factors in different settings. The prevalence of hypertension control in the low and middle-income countries and high-income countries studies ranged from (3.8% to 50.4%) to (36.3% to 69.6%), respectively. Concerning barriers to hypertension control, patient-related barriers were the most frequently reported, followed by medication adherence barriers, lifestyle-related barriers, barriers related to the affordability and accessibility of care, awareness-related barriers, and, finally, barriers related to prescribed pharmacotherapy.
  • 362
  • 09 Dec 2022
Topic Review
Monoclonal Antibodies Targeting CGRP
Now more than ever is the time of monoclonal antibody use in neurology. In headaches, disease-specific and mechanism-based treatments existed only for symptomatic management of migraines (i.e., triptans), while the standard prophylactic anti-migraine treatments consist of non-specific and repurposed drugs that share limited safety profiles and high risk for interactions with other medications, resulting in rundown adherence rates. Recent advances in headache science have increased our understanding of the role of calcitonin gene relate peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) pathways in cephalic pain neurotransmission and peripheral or central sensitization, leading to the development of monoclonal antibodies (mAbs) or small molecules targeting these neuropeptides or their receptors. Large scale randomized clinical trials confirmed that inhibition of the CGRP system attenuates migraine, while the PACAP mediated nociception is still under scientific and clinical investigation.
  • 361
  • 10 Aug 2021
Topic Review
Pharmacists and Medication Regimen Complexity
Medication regimen complexity (MRC) may influence health outcomes, such as hospitalisation, hospital readmission and medication adherence. Pharmacists have been referred to as health professionals with the opportunity to act on MRC reduction.
  • 361
  • 31 Aug 2021
Topic Review
Mushrooms as Therapeutic Adjuvant of Cancer Therapies
Mushrooms may act as a potentiator of host defense mechanisms and decrease adverse events in patients with cancer undergoing conventional therapies. 
  • 361
  • 21 Feb 2022
Topic Review
Drug Delivery Hurdles in Skin Cancer Treatment
Chemotherapy of skin cancer can be either oral, parenteral, or topical. In the first case, only a limited amount of the drug reaches the target site, while the rest reaches other organs, tissues, and cells, and can cause harmful side effects. The case is quite similar in parenteral application together with its invasiveness. Therefore, the local application on different skin cancer forms can gain in therapeutic efficacy and safety. The various types of gel formulations applied topically in the treatment of skin cancer was discussed. The most common gelling agents, their concentration and mechanism of action is also provided. The possibility to combine nanotechnology for improvement of drug loading and delivery by incorporation of nanoparticles into hydrogels is also evaluated. The main methods for gel characterization in the light of topical delivery of chemotherapeutics were summarized.
  • 362
  • 05 May 2023
Topic Review
Neuropeptides Inhibitors for Colorectal Cancer
Neuropeptides are mainly secreted from the human central and peripheral nervous systems. Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and perform various physiological functions. Conventional cancer treatments in clinical practice still present many drawbacks due to the lack of selectivity toward the target cell, drug-resistance, and side-effects, thus pushing for the development of new therapeutic agents and therapies. Recent research suggests that neuropeptides influence cancer cell proliferation, invasion, metastasis, and angiogenesis and, therefore, they could be exploited as a target for novel anticancer therapies. Very recently, targeted approaches that inhibit neuropeptides and their associated receptors are being developed in cancer treatment. 
  • 357
  • 29 Sep 2022
Topic Review
Intrathecal Pseudodelivery of Drugs for Neurodegenerative Diseases
Intrathecal pseudodelivery of drugs is a novel route to administer medications to treat neurodegenerative diseases based on the cerebrospinal fluid (CSF)-sink therapeutic strategy by means of implantable devices. 
  • 357
  • 10 Mar 2023
Topic Review
Effects of Hydroxytyrosol in Endothelial Functioning
Pharmacologists have been emphasizing and applying plant and herbal-based treatments in vascular diseases. Olives, for example, are a traditional symbol of the Mediterranean diet. Hydroxytyrosol is an olive-derived compound known for its antioxidant and cardioprotective effects. Acknowledging the merit of antioxidants in maintaining endothelial function warrants the application of hydroxytyrosol in endothelial dysfunction salvage and recovery. Endothelial dysfunction (ED) is an impairment of endothelial cells that adversely affects vascular homeostasis. Disturbance in endothelial functioning is a known precursor for atherosclerosis and, subsequently, coronary and peripheral artery disease.
  • 357
  • 10 Mar 2023
Topic Review
Drug Response Diversity
Interindividual heterogeneity in response to treatment is a real public health problem. It is a factor that can be responsible not only for ineffectiveness or fatal toxicity but also for hospitalization due to iatrogenic effects, thus increasing the cost of patient care. Several research teams have been interested in what may be at the origin of these phenomena, particularly at the genetic level and the basal activity of organs dedicated to the inactivation and elimination of drug molecules. Today, a new branch is being set up, explaining the enigmatic part that could not be explained before. Pharmacomicrobiomics attempts to investigate the interactions between bacteria, especially those in the gut, and drug response.
  • 356
  • 07 May 2021
Topic Review
The Bright Side of Psychedelics
Psychedelic-assisted psychotherapy (PAP) has emerged as an alternative strategy, one that arose in response to the crisis of new psychiatric drugs, there have been promising clinical trials of PAP with lysergic acid diethylamide (LSD), psilocybin and ibogaine to combat drug, alcohol and nicotine addiction. Potential applications have been found in the treatment of anxiety, obsessive compulsive disorders, major depression, autism spectrum disorders, and, finally, in delaying cognitive decline.
  • 356
  • 27 Mar 2023
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