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Topic Review
Chrysin
Pharmacological profile of phytochemicals has attracted much attention to their use in disease therapy. Since cancer is a major problem for public health with high mortality and morbidity worldwide, experiments have focused on revealing the anti-tumor activity of natural products. Flavonoids comprise a large family of natural products with different categories. Chrysin is a hydroxylated flavonoid belonging to the flavone category. Chrysin has demonstrated great potential in treating different disorders, due to possessing biological and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, etc. Over recent years, the anti-tumor activity of chrysin has been investigated, and in the present review, we provide a mechanistic discussion of the inhibitory effect of chrysin on proliferation and invasion of different cancer cells. Molecular pathways, such as Notch1, microRNAs, signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappaB (NF-κB), PI3K/Akt, MAPK, etc., as targets of chrysin are discussed. The efficiency of chrysin in promoting anti-tumor activity of chemotherapeutic agents and suppressing drug resistance is described. Moreover, poor bioavailability, as one of the drawbacks of chrysin, is improved using various nanocarriers, such as micelles, polymeric nanoparticles, etc. This updated review will provide a direction for further studies in evaluating the anti-tumor activity of chrysin.
  • 1.9K
  • 13 Oct 2020
Topic Review
Pseudoephedrine
Pseudoephedrine (PSE) is a drug with a long history of medical use; it is helpful in treating symptoms of the common cold and flu, sinusitis, asthma, and bronchitis.
  • 1.9K
  • 29 Jun 2021
Topic Review
Arsenic metabolism, excretion, and toxicity
       Arsenic is a global, naturally present pollutant found in drinking water that is consumed by millions of people throughout the world. Humans have evolved an arsenic methyltransferase present in high levels in the liver to expedite its excretion from the body. Most organisms have this enzyme. The enzyme generates monomethyl (MMA) and dimethyl arsenic (DMA). These methylated species are considered more toxic than arsenite, but they bind less tightly to proteins and thereby are excreted more rapidly from the body. Individuals who have been chronically exposed to arsenite were found to possess advantageous genotypes to metabolize arsenites. However, higher expression of AS3MT was found to yield more toxic MMA but lower amounts were still capable of metabolizing arsenite to DMA. This likely reflects the complex metabolic processes involving not only AS3MT, but antioxidants and upstream regulators of AS3MT, potentially transcription factor NRF2. This article discusses arsenic metabolism, excretion, toxicity, and the evolution of this enzyme across various species. The fact that so many organisms have evolved to possess this arsenite metabolizing enzyme is indicative of the widespread and ancient pollution of our drinking water by arsenite.
  • 1.9K
  • 09 Oct 2020
Topic Review
Histamine H1 Receptor Antagonists
Histamine H1 receptor (H1 receptor) antagonists are widely prescribed medications to treat allergic diseases, while recently it has emerged that they show significant promise as anti-SARS-CoV-2 agents.
  • 1.9K
  • 03 Jun 2021
Topic Review
Anthocyanins
Anthocyanins are biologically active water-soluble plant pigments that are responsible for blue, purple, and red colors in various plant parts—especially in fruits and blooms. Anthocyanins have attracted attention as natural food colorants to be used in yogurts, juices, marmalades, and bakery products. Numerous studies have also indicated the beneficial health effects of anthocyanins and their metabolites on humans, including free-radical scavenging and antioxidant activity.
  • 1.9K
  • 23 Sep 2020
Topic Review
Remote Monitoring of Vital Signs
Techniques for noncontact measurement of vital signs using camera imaging technologies have been attracting increasing attention. For noncontact physiological assessments, computer vision-based methods appear to be an advantageous approach that could be robust, hygienic, reliable, safe, cost effective and suitable for long distance and long-term monitoring. In addition, video techniques allow measurements from multiple individuals opportunistically and simultaneously in groups. This paper aims to explore the progress of the technology from controlled clinical scenarios with fixed monitoring installations and controlled lighting, towards uncontrolled environments, crowds and moving sensor platforms. We focus on the diversity of applications and scenarios being studied in this topic. From this review it emerges that automatic multiple regions of interest (ROIs) selection, removal of noise artefacts caused by both illumination variations and motion artefacts, simultaneous multiple person monitoring, long distance detection, multi-camera fusion and accepted publicly available datasets are topics that still require research to enable the technology to mature into many real-world applications.
  • 1.8K
  • 30 Oct 2020
Topic Review
Radix Polygoni Multiflori
Radix Polygoni Multiflori (RPM), the dry root of Polygonum multiflorum Thunb. (Fam. Polygonaceae), has been used as a tonic and an anti-aging remedy for centuries. However, its safe and effective application in clinical practice could be hindered by its liver injury potential and lack of investigations on its hepatotoxicity mechanism.
  • 1.8K
  • 07 Dec 2020
Topic Review
Dexibuprofen
S-(+) enantiomer of ibuprofen (IBU) dexibuprofen (DXI) is known to be more potent than its R-(−) form and exhibits many advantages over the racemic mixture of IBU such as lower toxicity, greater clinical efficacy, and lesser variability in therapeutic effects. Moreover, DXI potential has been recently advocated to reduce cancer development and prevent the development of neurodegenerative diseases in addition to its anti-inflammatory properties. 
  • 1.8K
  • 23 Jun 2021
Topic Review
Eugenol-based O/W Emulsion by Low-energy Emulsification
Emulsions are systems formed by two immiscible liquids, one of which is dispersed in the other as droplets with a relative stability. These have multiple applications, among them, in the formulation of pharmaceutical and cosmetic products. Its preparation requires generating a large interfacial area, which is usually attained by using the physicochemical formulation know-how on surfactant-oil-water (SOW) systems. Among the applications in the pharmaceutical industry, topical creams, and emulsions for intravenous and for oral administration can be found.  Eugenol can be extracted from cloves (Syzygium aromaticum) by various methods, including steam distillation, hydrodistillation and Soxhlet extraction. Furthermore, emulsions based on eugenol can be obtained for a variety of applications, including as topical and oral anesthetic. Nanoemulsions can be formulated with a mixture of non-ionic surfactants Span 20/Tween 80 at an HLB of 11 to 13 and a total surfactant concentration of 4%, using the dilution phase transition method (so-called spontaneous emulsification) to attain stable O/W eugenol-based emulsions. Paraffin oil/eugenol ratio of 4/1 can be used to reach a final emulsion internal oil phase content of 10% with 4% surfactant and 86% aqueous phase. Different polymers are used as viscosifiers, including carboxymethylcellulose. Under these conditions, eugenol-based emulsions with an average droplet size of less than 2 μm can be attained, with topical and oral anesthetic characteristics.
  • 1.8K
  • 03 Apr 2022
Topic Review
1,2,4-Triazoles
Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity.
  • 1.8K
  • 23 Aug 2021
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