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Topic Review
Secondary Metabolites from the Genus Acremonium
Acremonium fungi is one of the greatest and most complex genera in Hyphomycetes, comprising 130 species of marine and terrestrial sources. The past decades have witnessed substantial chemical and biological investigations on the diverse secondary metabolites from the Acremonium species. To date, over 600 compounds with abundant chemical types as well as a wide range of bioactivities have been obtained from this genus, attracting considerable attention from chemists and pharmacologists. 
  • 119
  • 18 Jan 2024
Topic Review
Nanodelivery Systems and Constituents Derived from Novel Foods
Novel Food is a new category of food, regulated by the European Union Directive No. 2015/2283. This latter norm defines a food as “Novel” if it was not used “for human consumption to a significant degree within the Union before the date of entry into force of that regulation, namely 15 May 1997”.  Due to their natural source, Novel Food can represent another new and not fully exploited reservoir of nutraceuticals. Indeed, Novel Food can also be considered an important source of raw matter to produce a nano-drug delivery system. The application of Novel Foods as new nanoceutical materials or bioactive compounds embedded into nanocarriers is a new research field, as these sources have been employed only in recent decades.
  • 119
  • 17 Nov 2023
Topic Review
Discovering Amino Acid Transporter Inhibitors
Amino acid transporters are abundant amongst the solute carrier family and have an important role in facilitating the transfer of amino acids across cell membranes. Because of their impact on cell nutrient distribution, they also appear to have an important role in the growth and development of cancer. Naturally, this has made amino acid transporters a novel target of interest for the development of new anticancer drugs. 
  • 117
  • 05 Mar 2024
Topic Review
Polypharmacy in Older Patients with COVID-19
Polypharmacy is the use of multiple and potentially inappropriate medications (PIMs) that lack sufficient evidence of benefits and/or increase the risks of adverse drug reactions. It is an increasing problem among older adults. The global polypharmacy prevalence is 34.6% in patients with COVID-19, and polypharmacy in COVID-19 increases with age. 
  • 105
  • 14 Mar 2024
Topic Review
Pharmaceutical Properties of Gabapentin
Gabapentin (GBP) is a common name for 1-(aminomethyl)cyclohexaneacetic acid (C9H17NO2, CAS Registry No. 60142-96-3), a GABA (γ-aminobutyric acid) derivative and a popular active pharmaceutical ingredient (API). It has a molecular weight of 171.34 and two pKa values of 3.68 and 10.70.
  • 102
  • 13 Mar 2024
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