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Topic Review
Biography
Topic Review
Demodex Mite in Human Skin
Saprophytic mites called Demodex are commonly found on the skin of adult humans. They are primarily present in the folliculosebaceous units of facial skin and are a part of the normal skin microbiota. When present in low numbers, they do not cause any harm. However, their increased density has been linked to certain skin disorders. For instance, Demodex infestation is frequently observed in rosacea, raising concerns about its role as a contributing factor in this condition.
396
21 Feb 2024
Topic Review
Genetics and Transcriptomics of Melanoma Metastasis
Melanoma is a deadly skin cancer with rapidly increasing incidence worldwide. The progression from melanomagenesis to metastasis is known to differ between the various subtypes of melanoma, which are defined by their disparate clinical, histopathologic, and genetic features.
395
11 Jan 2022
Topic Review
The Cutaneous Squamous Cell Carcinoma
Cutaneous squamous cell carcinoma (cSCC) arises from the abnormal proliferation of keratinocytes of the epidermis, most commonly due to UV-light-induced DNA damage. Although histopathological assessment is the gold standard for diagnosing cSCC, nascent optical imaging diagnostic modalities enable clinicians to perform “optical or virtual biopsy” in real-time.
395
12 Jul 2023
Topic Review
Skin Cancers
Skin cancer is a condition characterized by the abnormal growth of skin cells, primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Different types of skin cancer include melanoma, basal cell carcinoma, and squamous cell carcinoma.
391
04 Sep 2023
Topic Review
The Local Neuropeptide System of Keratinocytes
The synthesis and activity of neuropeptides and their receptors in epithelial cells of the skin and mucous membranes. Note that the term "neuropeptide" was originally coined to indicate small protein molecules that are contained in neurons, however it is now known that the synthesis of this class of peptides is not restricted to neurons.
388
04 Jan 2022
Topic Review
Microbiology of Skin Wounds
The skin is the largest organ of the animal and human body and protects the internal organs from a variety of injuries as well as infectious agents. The microbiota of the skin is composed of bacteria, fungi, and viruses. Together, they form a complex ecosystem that plays a role in the defence against pathogens and in the development of the host’s immune system. Once the skin barrier is breached, the originally commensal bacteria become pathogens. They cause persistent inflammation and delay healing, leading to the development of chronic wounds typical of diabetics, immobile patients, and the elderly.
387
25 Jul 2022
Topic Review
Optimum Biopsy Site for Direct Immunofluorescence
Direct immunofluorescence of skin and oral mucosa is a vital diagnostic test for assessing vesiculobullous disorders, vasculitides, and connective tissue diseases. It is a robust and valuable technique that offers essential diagnostic information for many critical dermatoses. Dermatopathologists depend heavily on the data obtained from direct immunofluorescence evaluation to confirm final diagnoses.
382
07 Feb 2024
Topic Review
Pathogenesis of Atopic Dermatitis and Psoriasis
Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized societies, influenced by both environmental changes and a genetic predisposition.
381
24 Jan 2024
Topic Review
Mechanisms of Therapeutics and Cosmetic Agents against Aging
Skin is the protective physical barrier that protects our body against harm from the hazardous effects of ultraviolet (UV) radiation and the infiltration of pathogens, as well as the dehydration process. Skin aging can be divided into two types of processes: intrinsic, or chronological aging, and extrinsic aging. The agents presented here were chosen as representatives of some of the most commonly used types of anti-aging therapeutics.
378
13 Apr 2023
Topic Review
Radiation Therapy in Non-Melanoma Skin Cancer Treatment
Non-melanoma skin cancer (NMSC) is the most common malignancy in the United States. While surgery is considered as the main treatment modality for both cutaneous basal cell carcinoma (cBCC) and cutaneous squamous cell carcinoma (cSCC), radiotherapy plays an important role in the treatment of NMSC, both in the adjuvant setting for cases considered high-risk for recurrence, and in the definitive setting, when surgery is not feasible or desired by the patient.
377
26 May 2023
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