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All Topic Review Biography
Topic Review
Timeline of Typhoid Fever
This is a Timeline of typhoid fever, describing major events such as scientific/medical developments and notable epidemics.
  • 1.2K
  • 14 Nov 2022
Topic Review
Sports performance and systems theories
The purpose is to present a brief idea about the understanding of sports performance through the lens of systems theories.
  • 1.2K
  • 26 Oct 2020
Biography
Roger Shepard
Roger Newland Shepard (born January 30, 1929) is an American cognitive scientist and author of the "universal law of generalization" (1987). He is considered a father of research on spatial relations. He studied mental rotation, and was an inventor of non-metric multidimensional scaling, a method for representing certain kinds of statistical data in a graphical form that can be apprehended by hu
  • 1.2K
  • 30 Nov 2022
Topic Review
Zeolite/Pharmaceuticals System
Zeolites belong to aluminosilicate microporous solids, with strong and diverse catalytic activity, which makes them applicable in almost every kind of industrial process, particularly thanks to their eco-friendly profile. Another crucial characteristic of zeolites is their tremendous adsorption capability. Therefore, it is self-evident that the widespread use of zeolites is in environmental protection, based primarily on the adsorption capacity of substances potentially harmful to the environment, such as pharmaceuticals, pesticides, or other industry pollutants. On the other hand, zeolites are also recognized as drug delivery systems (DDS) carriers for numerous pharmacologically active agents. The enhanced bioactive ability of DDS zeolite as a drug carrying nanoplatform is confirmed, making this system more specific and efficient, compared to the drug itself. These two applications of zeolite, in fact, illustrate the importance of (ir)reversibility of the adsorption process. 
  • 1.2K
  • 11 Aug 2022
Topic Review
Glutamatergic Neurotransmission in Alzheimer’s Disease
Alzheimer’s disease (AD) is an age-related dementia and neurodegenerative disorder, characterized by Aβ and tau protein deposition impairing learning, memory, and suppressing synaptic plasticity of neurons. Increasing evidence suggests that there is a link between the glucose and glutamate alterations with age that down-regulates glucose utilization reducing glutamate levels in AD patients. Deviations in brain energy metabolism reinforce the development of AD by hampering glutamate levels in the brain. Glutamate is a nonessential amino acid and the major excitatory neurotransmitter synthesized from glucose. Alterations in cerebral glucose and glutamate levels precede the deposition of Aβ plaques. In the brain, over 40% of neuronal synapses are glutamatergic and disturbances in glutamatergic function have been implicated in the pathophysiology of AD. Nevertheless, targeting the glutamatergic system seems to be a promising strategy to develop novel, improved therapeutics for AD. Thus, the present review will extensively cover recent findings on the dysregulation of glutamatergic signaling in AD and will highlight the molecular mechanisms through which the modulation of glutamatergic receptors and transporters might exert beneficial effects in AD treatment.
  • 1.2K
  • 10 Nov 2020
Topic Review
Metformin
Metformin is a metabolic modulator widely used to treat type II diabetes and metabolic syndrome patients. It shows a safe profile and its use in additional indications, such as cancer, is an important matter of investigation.
  • 1.2K
  • 09 Dec 2020
Topic Review
Social Distancing
Social Distancing is a new terminology that became a popular term since mid-2020, after a global hit and pandemic by the new generation of the coronavirus (COVID-19). Social distancing is the act of maintaining a safe distance (equal to 6 feet or 2 meters) between individuals as a recommended solution by the World Health Organisation (WHO) to minimise the spread of COVID-19 in public places.  By the end of 2020, the majority of governments and national health authorities have set the 2-meter physical distancing as a mandatory measure in shopping centres, schools, pubs, restaurants, and public places.   
  • 1.2K
  • 06 Mar 2021
Topic Review
the Major Facilitator Superfamily
Bacterial pathogens are serious causative agents of infectious disease. Such microorganisms are resistant to multiple antimicrobial agents, thereby compromising the therapeutic efficacy of treatment.  Multidrug-resistant pathogens harbor antimicrobial efflux pumps, many transporters of which are members of the extensive major facilitator superfamily of proteins. These bacterial multidrug efflux pumps are good molecular targets for modulation and possible inhibition.  This entry briefly discusses several current developments for drug efflux pump modulation. 
  • 1.2K
  • 27 Oct 2020
Topic Review
Structural Family Therapy
Structural family therapy (SFT) is a method of psychotherapy developed by Salvador Minuchin which addresses problems in functioning within a family. Structural family therapists strive to enter, or "join", the family system in therapy in order to understand the invisible rules which govern its functioning, map the relationships between family members or between subsets of the family, and ultimately disrupt dysfunctional relationships within the family, causing it to stabilize into healthier patterns. Minuchin contends that pathology rests not in the individual, but within the family system. SFT utilizes, not only a special systems terminology, but also a means of depicting key family parameters diagrammatically. Its focus is on the structure of the family, including its various substructures. In this regard, Minuchin is a follower of systems and communication theory, since his structures are defined by transactions among interrelated systems within the family. He subscribes to the systems notions of wholeness and equifinality, both of which are critical to his notion of change. An essential trait of SFT is that the therapist actually enters, or "joins", with the family system as a catalyst for positive change. Joining with a family is a goal of the therapist early on in his or her therapeutic relationship with the family. Structural and Strategic therapy are important therapeutic models to identify as many therapists use these models as the bases for treatment. Each model has its own approach using different ways in conceptualizing a problem and developing treatment plans that support the goals stated for therapy. In addition, theory-based treatment plans are the source for goal development and treatment options by identifying the presenting problem and social influences. Both these models use similar approaches and define goals with various therapeutic processes that begin with the building of therapist and client relationship. In addition, diversity and theory are identified as a major component in choosing a theory that addresses diversity issues.
  • 1.2K
  • 28 Oct 2022
Topic Review
Chronic Kidney Disease
Nutrition is a cornerstone in the management of chronic kidney disease (CKD). To limit urea generation and accumulation, a global reduction in protein intake is routinely proposed. However, recent evidence has accumulated on the benefits of plant-based diets and plant-derived proteins without a clear understanding of underlying mechanisms. Particularly the roles of some amino acids (AAs) appear to be either deleterious or beneficial on the progression of CKD and its complications.
  • 1.2K
  • 05 Jan 2021
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