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Topic Review
Anemia in Kawasaki disease
Kawasaki disease (KD) is an acute childhood vasculitis syndrome that affects the walls of both small- and medium-sized blood vessels (vasculitis), especially coronary arteries. Anemia is a common clinical feature in KD patients and is thought to have a more prolonged duration of active inflammation. In this review, we will discuss the anemia in KD, possibility of hemolysis, the necessity of iron supplementation and importance of anemia in the pathogenesis of KD.
  • 4.0K
  • 05 Nov 2020
Topic Review
Anesthesia in Children with Neuroblastoma
Neuroblastoma (NB) is the most common extracranial, solid, pediatric malignancy and, despite the constant progress of treatment and development of innovative therapies, remains a complex, challenging disease causing major morbidity and mortality in children.
  • 1.0K
  • 03 Jun 2021
Topic Review
Anesthesiologist Assistant
In the United States , anesthesiologist assistants - known in full as certified anesthesiologist assistants - are master's degree prepared clinicians that practice medicine under the direction of licensed anesthesiologists to implement anesthesia care plans for a patient undergoing surgery. CAAs are integral members of the anesthesia care team as described by the American Society of Anesthesiologists (ASA). All CAAs possess a baccalaureate degree (in any field with a major focus on pre med sciences), and complete an intensive didactic and clinical program at a postgraduate level. CAAs are trained in the delivery and maintenance of all types of anesthesia care as well as advanced patient monitoring techniques under the direction of a physician anesthesiologist. The goal of CAA education is to guide the transformation of student applicants into competent clinicians who aspire to practice in the anesthesia care team.
  • 391
  • 20 Oct 2022
Topic Review
Anesthesiology
Anesthesia literally means without sensation. There are a number of different types of anesthesia. They allow for safe and comfortable conscious or unconscious experiences during a surgical procedure.
  • 542
  • 10 May 2021
Topic Review
Anesthetics and Cell–Cell Communication
Cell–cell communication via gap junction channels is known to be inhibited by the anesthetics heptanol, halothane and isoflurane; despite numerous studies, the mechanism of gap junction channel gating by anesthetics is still poorly understood.
  • 293
  • 20 Feb 2023
Topic Review
Anesthetics and Long Term Cancer Outcomes
Anesthetics are chemical factors with the potential to induce epigenetic effects. With regard to the nervous system, for example, this is supported by the fact that anesthetics are neurotoxins sharing many molecular mechanisms of action with alcohol and cocaine.
  • 275
  • 18 Aug 2022
Topic Review
Aneurysm prevention in Kawasaki Disease
 A form of systemic vasculitis that affects mostly small and medium-sized vessels, Kawasaki disease (KD) is most commonly found in children under the age of 5 years old. Though its etiology is unknown, KD has been the most frequent acquired heart disease in developing countries. The most severe complications of KD are coronary artery lesions (CAL), including dilation, fistula, aneurysm, arterial remodeling, stenosis, and occlusion. Aneurysm formation has been observed in 20-25% of KD patients that do not receive intravenous immunoglobulin (IVIG) treatment, and in 3-5% that do receive it. Coronary artery dilation has been found in about 30% of KD patients in the acute stage, although mostly in the transient form. Diminishing the occurrence and regression of aneurysm is a vital part of treating KD. This review is focuing on coronary artery aneurysm prevention in KD.
  • 1.1K
  • 02 Nov 2020
Topic Review
Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation
Aneurysmal subarachnoid hemorrhage (SAH) can lead to devastating outcomes including vasospasm, cognitive decline, and even death. Treatment options are limited for this potentially life threatening injury. Evidence suggests that neuroinflammation plays a critical role in injury expansion and brain damage. Red blood cell breakdown products can lead to the release of inflammatory cytokines that trigger vasospasm and tissue injury. Preclinical models have been used successfully to improve understanding about neuroinflammation following aneurysmal rupture.
  • 120
  • 29 Feb 2024
Topic Review
Angina in 2022
Cardiovascular disease is the leading cause of death worldwide and ischemic heart disease is responsible for approximately half of these deaths. Angina is the main symptom of ischemic heart disease; mirroring a mismatch between oxygen supply and demand.
  • 506
  • 30 Nov 2022
Topic Review
Angiocrine Factors Control Tumor Progression
A solid tumor mass consists not only of cancer cells, but of numerous other resident and infiltrating cells and the extracellular matrix, which together form the tumor microenvironment (TME). The TME contains three main cell entities: fibroblasts, immune cells and endothelial cells. Endothelial cells control their microenvironment through the expression of membrane-bound and secreted factors. Such angiocrine functions are frequently hijacked by cancer cells, which deregulate the signaling pathways controlling the expression of angiocrine factors.
  • 679
  • 23 Jun 2021
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