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Topic Review
Fluoroquinolones-Associated Disability
Fluoroquinolones (FQs) are one of the most commonly prescribed antibiotics within the United States. FQs are typically included in the treatment protocols of several illnesses such as urinary tract infections, bacterial bronchitis, bacterial gastroenteritis and other infectious diseases. However, it is clear now that FQs lead to severe, long-lasting side effects that require further investigation to ensure better disease management.
  • 1.2K
  • 21 Jul 2021
Topic Review
Spray Drying for Direct Compression
Direct compression is a simple, quick and cost-effective drug manufacturing approaches of tableting.
  • 1.2K
  • 25 Feb 2021
Topic Review
Action Sports
In the last two decades, non-traditional sports activities characterized by elements such as speed, height, and exposure to natural forces knew a rapid increase in global participation. They are generally referred to as action sports (AS), with the terms adventure sports or extreme sports that could be used as interchangeable synonyms.
  • 1.2K
  • 09 Dec 2020
Topic Review
Equine Endometrium Morphology
Mares are seasonal polyestric. The morphology of the healthy equine endometrium is influenced by the season of the year, the stage of the endometrial cycle, as well as the presence of endometrial diseases. The latter have an impact on the wellbeing of individual mares and can also inflict major financial losses for the horse breeding industry. The microscopic examination of an endometrial biopsy is an important diagnostic tool, since it can also detect subclinical diseases. This review provides an overview about morphological and molecular features of the healthy and diseased equine endometrium. It reviews the diagnostic findings of inflammatory and degenerative endometrial disease of mares, as well as the current state of knowledge regarding their cellular and molecular pathogenesis. It further shows that the comparative evaluation of morphological features and molecular characteristics of the healthy and diseased equine endometrium is an important prerequisite for the identification of disease-associated molecular markers, which in turn will facilitate the development of diagnostic and predictive biomarkers, as well as novel prophylactic and therapeutic options. Although currently numerous molecular data are already available, future studies are required to establish their translation into clinical practice.
  • 1.2K
  • 01 Nov 2020
Topic Review
BCL-2 Proteins in Pathogenesis
The ability to inhibit mitochondrial apoptosis is a hallmark of B-cell non-Hodgkin lymphomas (B-NHL). Activation of mitochondrial apoptosis is tightly controlled by members of B-cell leukemia/lymphoma-2 (BCL-2) family proteins via protein-protein interactions. Altering the balance between anti-apoptotic and pro-apoptotic BCL-2 proteins leads to apoptosis evasion and extended survival of malignant cells. The pro-survival BCL-2 proteins: B-cell leukemia/lymphoma-2 (BCL-2/BCL2), myeloid cell leukemia-1 (MCL-1/MCL1) and B-cell lymphoma-extra large (BCL-XL/BCL2L1) are frequently (over)expressed in B-NHL, which plays a crucial role in lymphoma pathogenesis, disease progression, and drug resistance. 
  • 1.2K
  • 23 Jun 2021
Topic Review
Nonsense-Mediated mRNA Decay
Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a surveillance pathway used by cells to control the quality mRNAs and to fine-tune transcript abundance. NMD plays an important role in cell cycle regulation, cell viability, DNA damage response, while also serving as a barrier to virus infection. Disturbance of this control mechanism caused by genetic mutations or dys-regulation of the NMD pathway can lead to pathologies, including neurological disorders, immune diseases and cancers. The role of NMD in cancer development is complex, acting as both a promoter and a barrier to tumour progression. Cancer cells can exploit NMD for the downregulation of key tumour suppressor genes, or tumours adjust NMD activity to adapt to an aggressive immune microenvironment.
  • 1.2K
  • 22 Sep 2021
Topic Review Peer Reviewed
COVID-19 and Dentistry
Dentistry is a healthcare profession requiring close contacts between the dental practitioner and the patient. In particular, many dental procedures generate aerosols and droplets which are proved to be the major transmission route for COVID-19.
  • 1.2K
  • 13 Apr 2022
Topic Review
Applications of BioHPP in Prosthetic Dentistry
BioHPP is not only extremely interesting for the future, but possesses characteristics suitable for clinical application today, for endocrowns, small adhesive bridges, temporary prostheses and for immediate loads on implant restorations. The excellent aesthetics and the possibility of simple reprocessing of the restorations made with this material invite its clinical application. 
  • 1.2K
  • 28 Mar 2022
Topic Review
Biological Theories of Dyslexia
The primary symptoms of dyslexia were first identified by Oswald Berkhan in 1881. The term dyslexia was coined in 1887 by Rudolf Berlin, an ophthalmologist practicing in Stuttgart, Germany . Since then generations of researchers have been investigating what dyslexia is and trying to identify the biological causes. The theories of the etiology of dyslexia have and are evolving with each new generation of dyslexia researchers, and the more recent theories of dyslexia tend to enhance one or more of the older theories as understanding of the nature of dyslexia evolves. Theories should not be viewed as competing, but as attempting to explain the underlying causes of a similar set of symptoms from a variety of research perspectives and background.
  • 1.2K
  • 09 Oct 2022
Topic Review
Mindfulness and Technology
Mindfulness and technology is a movement in research and design, that encourages the user to become aware of the present moment, rather than losing oneself in a technological device. This field encompasses multidisciplinary participation between design, psychology, computer science, and religion. Mindfulness stems from Buddhist meditation practices and refers to the awareness that arises through paying attention on purpose in the present moment, and in a non-judgmental mindset. In the field of Human-Computer Interaction, research is being done on Techno-spirituality — the study of how technology can facilitate feelings of awe, wonder, transcendence, and mindfulness and on Slow design, which facilitates self-reflection. The excessive use of personal devices, such as smartphones and laptops, can lead to the deterioration of mental and physical health. This area focuses on redesigning and creating technology to improve the wellbeing of its users.
  • 1.2K
  • 28 Sep 2022
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