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Topic Review
Environmental Awareness and Individual’s Altruism
Environmental awareness is the level of how much people are interested in or care about environmental issues. Environmental awareness can be either local or global one depending on the type of environmental problem. Studies have argued that this awareness tends to be related to an individual’s altruism, which is one’s action that benefits others without expecting some kind of external reward. The connection between environmental awareness and altruism is getting attention from scholars since both concepts are prosocial ones but it is uncertain if people who are highly aware of environmental issues may not be always acting altruistically. However, it is likely that altruistic people are more likely to have high environmental awareness.
  • 4.7K
  • 28 Oct 2020
Topic Review
Healthy Benefits of Natural Pigments
Natural pigments, including carotenoids, flavonoids and anthocyanidins, determine the attractive color of fruits. These natural pigments are essential secondary metabolites, which play multiple roles in the whole life cycle of plants and are characterized by powerful antioxidant activity. After decades of research and development, multiple benefits of these natural pigments to human health have been explored and recognized and have shown bright application prospects in food, medicine, cosmetics and other industries. 
  • 4.6K
  • 17 May 2021
Topic Review
Community Counseling
Guidance and counseling is a process of helping an individual become fully aware of his/ herself and the ways in which he is responding to the influence of his/her environment. Counseling is a generic term for any of professional counseling that treats dysfunction occurring within a group of related people. This term describes a preventive system of counseling that works to combat psychological impairment through the improvement and development of community support. A community is defined as a group of interacting individuals who share a commonality. This commonality can be anything from location of residence to career interest, but a community counselor will use this common characteristic to council groups of people.
  • 4.6K
  • 17 Oct 2022
Topic Review
Lipsticks History, Formulations, and Production
Lipsticks are one of the most widely used cosmetic products. Social, psychological, and therapeutic benefits can be attained from using lipstick. The beauty and attractiveness of a person are enhanced as lipsticks colour the lips and protect them from the external environment.
  • 4.6K
  • 02 Mar 2022
Topic Review
Short-Chain Fatty Acids
The relationship between diet and the diversity and function of the intestinal microbiome and its importance for human health is currently the subject of many studies. The type and proportion of microorganisms found in the intestines can determine the energy balance of the host. Intestinal microorganisms perform many important functions, one of which is participation in metabolic processes, e.g., in the production of short-chain fatty acids—SCFAs (also called volatile fatty acids). These acids represent the main carbon flow from the diet to the host microbiome. Maintaining intestinal balance is necessary to maintain the host’s normal health and prevent many diseases. The results of many studies confirm the beneficial effect of probiotic microorganisms on the balance of the intestinal microbiome and produced metabolites, including SCFAs. The aim of this review is to summarize what is known on the effects of probiotics on the production of short-chain fatty acids by gut microbes. In addition, the mechanism of formation and properties of these metabolites is discussed and verified test results confirming the effectiveness of probiotics in human nutrition by modulating SCFAs production by intestinal microbiome is presented.
  • 4.5K
  • 30 Oct 2020
Topic Review
Apoptosis
Apoptosis is a multistep process that involves two major pathways to trigger a cascade of events leading to the fragmentation of chromatin, nuclear membrane, and cell shrinkage. However, when this physiological process tended to be dysregulated, many pathological transformations happen to develop cancer.
  • 4.5K
  • 23 Jun 2021
Topic Review
Football Goalkeeper Injuries
Knowledge and research about football goalkeeper (GK) injuries are scarce, which prevents the development of evidence-based injury prevention programs. Fortunately, progress is evident in injury prevention strategies in outfield football players. However, a GK fulfills a unique role, and an injured GK can substantially impact a team. Thus, there is a need to clarify and summarize current knowledge concerning football goalkeeper pain and injuries.
  • 4.4K
  • 31 May 2021
Topic Review
Burnside-Butler Syndrome Genotype-Phenotype Associations
The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most common cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. Clinical findings in Burnside-Butler syndrome include developmental and motor delays, congenital abnormalities, learning and behavioral problems, and abnormal brain findings. To better define symptom presentation, we performed comprehensive cognitive and behavioral testing, collected medical and family histories, and conducted clinical genetic evaluations. The 15q11.2 BP1-BP2 region includes the TUBGCP5, CYFIP1, NIPA1, and NIPA2 genes. To determine if additional genomic variation outside of the 15q11.2 region influences expression of symptoms in Burnside-Butler syndrome, whole-exome sequencing was performed on the parents and affected children for the first time in five families with at least one parent and child with the 15q1l.2 BP1-BP2 deletion. In total, there were 453 genes with possibly damaging variants identified across all of the affected children. Of these, 99 genes had exclusively de novo variants and 107 had variants inherited exclusively from the parent without the deletion. There were three genes (APBB1, GOLGA2, and MEOX1) with de novo variants that encode proteins evidenced to interact with CYFIP1. In addition, one other gene of interest (FAT3) had variants inherited from the parent without the deletion and encoded a protein interacting with CYFIP1. The affected individuals commonly displayed a neurodevelopmental phenotype including ASD, speech delay, abnormal reflexes, and coordination issues along with craniofacial findings and orthopedic-related connective tissue problems. Of the 453 genes with variants, 35 were associated with ASD. On average, each affected child had variants in 6 distinct ASD-associated genes (x¯ = 6.33, sd = 3.01). In addition, 32 genes with variants were included on clinical testing panels from Clinical Laboratory Improvement Amendments (CLIA) approved and accredited commercial laboratories reflecting other observed phenotypes. Notably, the dataset analyzed in this study was small and reported results will require validation in larger samples as well as functional follow-up. Regardless, we anticipate that results from our study will inform future research into the genetic factors influencing diverse symptoms in patients with Burnside-Butler syndrome, an emerging disorder with a neurodevelopmental behavioral phenotype.
  • 4.4K
  • 25 Mar 2021
Topic Review
Propranolol in Post-Traumatic Stress Disorder
Propranolol, a non-cardioselective β1,2 blocker, is most commonly recognised for its application in the therapy of various cardiovascular conditions, such as hypertension, coronary artery disease, and tachyarrhythmias. However, due to its ability to cross the blood–brain barrier and affinity towards multiple macromolecules, not only adrenoreceptors, it has also found application in other fields. For example, it is one of the very few medications successfully applied in the treatment of stage fright. 
  • 4.4K
  • 07 Sep 2022
Topic Review
NAFLD and Cardiovascular Comorbidities
Non-alcoholic fatty liver disease (NAFLD) is a liver disease that can progress from hepatic steatosis to steatohepatitis and even cirrhosis and hepatocellular carcinoma. From the histopathological point of view, it is characterized by excess storage of macrovesicular fat in hepatocytes. These macrovesicular storages are composed of triglycerides that accumulate in the liver. The process can lead in some individuals to an inflammatory response, which is responsible for steatohepatitis, that leads to fibrosis and, finally, cirrhosis.NAFLD has a growing prevalence in recent years. Its association with cardiovascular disease has been intensively studied, and certain correlations have been identified. The connection between these two entities has lately aroused interest regarding therapeutic management. 
  • 4.3K
  • 07 May 2021
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