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Topic Review
Fat Redistribution
Type 2 diabetes (T2D) is a chronic condition where the body is resistant to insulin leading to an elevated blood glucose state. Obesity is a main factor leading to T2D. Many clinical studies, however, have described a proportion of obese individuals who express a metabolically healthy profile, whereas some lean individuals could develop metabolic disorders. To study obesity as a risk factor, body fat distribution needs to be considered rather than crude body weight. Different individuals’ bodies favor storing fat in different depots; some tend to accumulate more fat in the visceral depot, while others tend to store it in the femoral depot. This tendency relies on different factors, including genetic background and lifestyle. Consuming some types of medications can cause a shift in this tendency, leading to fat redistribution. Fat distribution plays an important role in the progression of the risk of insulin resistance (IR). Apple-shaped individuals with enhanced abdominal obesity have a higher risk of IR compared to BMI-matched pear-shaped individuals who store their fat in the gluteal-femoral depots. This is related to the different adipose tissue physiology between these two depots. In this text, the recent evidence showing antidiabetic drugs that impact fat distribution as they manage the T2D condition is summarized. 
  • 1.3K
  • 14 Nov 2022
Topic Review
Sick Leave
Sick leave (or paid sick days or sick pay) is time off from work that workers can use to stay home to address their health and safety needs without losing pay. Paid sick leave is a statutory requirement in many nations. Most European, many Latin American, a few African and a few Asian countries have legal requirements for paid sick leave. The Book of Leviticus prescribed (7) days of medical isolation for a skin condition in chapter 13. Already in 1500 BCE, at least some of the workers who built the tombs of Egyptian pharaohs received paid sick leave as well as state-supported health care. In nations without laws mandating paid sick leave, some employers choose to offer it. Those that do offer sick leave do so as a matter of workplace policy or because it is in some or all of the employees' employment contracts or required by a collective bargaining agreement. Currently, nine US states (Arizona, California, Connecticut, Maryland, Massachusetts, Oregon, Rhode Island, Vermont, Washington); 23 US cities; and two US counties (Montgomery County, MD and San Francisco County, CA) have laws mandating paid sick leave. Currently, there are additional US city, county and state jurisdictions with proposed legislation to enact paid sick leave.
  • 1.3K
  • 30 Oct 2022
Topic Review Peer Reviewed
Physical Properties of Helium and Application in Respiratory Care
Helium is a low-density, inert, monoatomic gas that is widely used in medical applications. In respiratory care, Helium is mainly used as an adjunct therapy for patients with severe upper airway obstruction and asthma. To better understand the action mechanism of helium, the physical properties of several therapeutic gas mixtures with helium are calculated using kinetic theory. Flow in a simplified lung airways model is also shown to support the discussion of helium’s respiratory benefits, including reduced work of breathing.
  • 1.3K
  • 02 Nov 2023
Topic Review
Italian Experts’ Statements on Paracetamol/Ibuprofen in Children Fever/Pain
Fever and pain are challenging symptoms in children and adolescents and are common reasons for consultations in primary care and hospital. Paracetamol and ibuprofen are currently the only recommended drugs for treating fever in Italy, but the therapeutic approaches are discrepant in the different settings.
  • 1.3K
  • 08 Nov 2021
Topic Review
Src and Hippo/YAP in NSCLC
The advancement of new therapies, including targeted therapies and immunotherapies, has improved the survival of non-small-cell lung cancer (NSCLC) patients in the last decade. Some NSCLC patients still do not benefit from therapies or encounter progressive disease during the course of treatment because they have intrinsic resistance, acquired resistance, or lack a targetable driver mutation. More investigations on the molecular biology of NSCLC are needed to find useful biomarkers for current therapies and to develop novel therapeutic strategies. Src is a non-receptor tyrosine kinase protein that interacts with cell surface growth factor receptors and the intracellular signaling pathway to maintain cell survival tumorigenesis in NSCLC. The Yes-associated protein (YAP) is one of the main effectors of the Hippo pathway and has been identified as a promoter of drug resistance, cancer progression, and metastasis in NSCLC. Here, we review studies that have investigated the activation of YAP as mediated by Src kinases and demonstrate that Src regulates YAP through three main mechanisms: (1) direct phosphorylation; (2) the activation of pathways repressing Hippo kinases; and (3) Hippo-independent mechanisms. Further work should focus on the efficacy of Src inhibitors in inhibiting YAP activity in NSCLC. In addition, future efforts toward developing potentially reasonable combinations of therapy targeting the Src–YAP axis using other therapies, including targeted therapies and/or immunotherapies, are warranted.
  • 1.3K
  • 15 Oct 2020
Topic Review Video Peer Reviewed
Sheet Barrier and Intubating Stylet
Coronavirus disease 2019 (COVID-19), a respiratory syndrome caused by SARS-CoV-2, can be transmitted through respiratory droplets and aerosols of droplet nuclei. Aerosol-generating medical procedures (AGMP) are needed to take care of critically ill patients but place health care providers at risk of infection. With limited supplies of personal protective equipment (PPE), barrier systems were developed to help protect health care providers during tracheal intubation. The video intubating stylet shows promise to become the preferred intubation device in conjunction with plastic sheet barriers during the COVID-19 pandemic.
  • 1.2K
  • 13 Apr 2022
Topic Review
Immunologic Adverse Reactions to Food
Adverse food reactions include immune-mediated food allergies and non-immune-mediated intolerances. However, this distinction and the involvement of different pathogenetic mechanisms are often confused. Furthermore, there is a discrepancy between the perceived vs. actual prevalence of immune-mediated food allergies and non-immune reactions to food that are extremely common. The risk of an inappropriate approach to their correct identification can lead to inappropriate diets with severe nutritional deficiencies.
  • 1.3K
  • 23 Jun 2021
Topic Review
Protein Subcellular Localization
Proteins are localized into different cellular compartments and sub-compartments inside the cell. Each subcellular compartment has a distinct well-defined function in the cell and has a characteristic physicochemical environment, which drives proper functioning of the proteins. Each subcellular compartment has a distinct, well defined function in the cell and is considered to have evolved from the prokaryotic cell. Typical eukaryotic cells have two types of DNAs (i) chromosomal nuclear DNA and (ii) organelle DNA, which is present in mitochondria and chloroplast while prokaryotic cells have only single type of DNA called nucleoid.
  • 1.3K
  • 18 Feb 2021
Topic Review
Children with Neurodevelopmental Disabilities
This entry aimed to undertake an extensive exploration of the extent, range, and nature of research activities regarding the effect and emerging evidence in the field of physical activity interventions on cognitive development among children and youth (0–17.99 years) with neurodevelopmental disorders (NDD), and to help identify key gaps in research and determine precise research questions for future investigations. To carry out this scoping review, five electronic databases were searched. A total of 12,097 articles were retrieved via search efforts with an additional 93 articles identified from the identified review papers. Sixty articles were eligible for inclusion. The results of this scoping review revealed many positive key cognitive outcomes related to physicalactivity including, but not limited to: focus, attention, self-control, cognitive process, and alertness. No studies reported a negative association between physical activity and cognitive outcomes. Based on the findings from this scoping review, physical activity appears to have a favorable impact on the cognitive outcomes of children and youth with NDD. 
  • 1.3K
  • 23 Mar 2021
Topic Review
Local Anesthesia in Cancer Surgeries
The application of local anaesthetics is frequently involved in anaesthesia in the surgical treatment of various cancers. It is used in addition to or instead of general anaesthesia as a way to provide control of sensation and pain to specific regions or parts of the patients' bodies. They are thought to reduce the requirement for volatile anaesthetics and opioids used in the surgery.
  • 1.3K
  • 28 Feb 2021
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