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Topic Review
Persistent Post-Concussion Syndrome
Persistent post-concussion syndrome (PPCS) is a complex and debilitating condition that can develop after head concussions or mild traumatic brain injury (mTBI). PPCS is characterized by a wide range of symptoms, including headaches, dizziness, fatigue, cognitive deficits, and emotional changes, that can persist for months or even years after the initial injury. Despite extensive research, the underlying mechanisms of PPCS are still poorly understood; furthermore, there are limited resources to predict PPCS development in mTBI patients and no established treatment. Similar to PPCS, the etiology and pathogenesis of functional neurological disorders (FNDs) are not clear neither fully described. Nonspecific multifactorial interactions that were also seen in PPCS have been identified as possible predispositions for FND onset and progression. 
  • 215
  • 15 Sep 2023
Topic Review
Intricate Factors Shaping Craniofacial Structure and Sleep-Disordered Breathing
Adenotonsillar hypertrophy has been well-acknowledged as the primary instigator of sleep-disordered breathing in the pediatric population. This condition spans a spectrum, from typical age-related growth that the immune system influences to persistent pathological hypertrophy. Reduction in air spaces, metabolic changes, neurobehavioral alterations, and chronic inflammation characterizes the latter form. As the go-to treatment, adenotonsillectomy has proven effective.
  • 143
  • 15 Sep 2023
Topic Review
Constrained-Disorder Principle-Based Systems Improve Digital Twins Performance
Digital twins are computer programs that use real-world data to create simulations that predict the performance of processes, products, and systems. Digital twins may integrate artificial intelligence to improve their outputs. Models for dealing with uncertainties and noise are used to improve the accuracy of digital twins. Most used systems aim to reduce noise to improve their outputs. Nevertheless, biological systems are characterized by inherent variability, which is necessary for their proper function. The constrained-disorder principle defines living systems as having a disorder as part of their existence and proper operation while kept within dynamic boundaries.
  • 212
  • 15 Sep 2023
Topic Review
Neuroinflammatory Implications of Gut Microbiota in Alzheimer’s Disease
The bidirectional communication between the central nervous system (CNS) and the gut microbiota plays a pivotal role in human health. Increasing numbers of studies suggest that the gut microbiota can influence the brain and behavior of patients. Various metabolites secreted by the gut microbiota can affect the cognitive ability of patients diagnosed with neurodegenerative diseases. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory, language, and cognitive ability.
  • 245
  • 15 Sep 2023
Topic Review
Carbon Ions for Hypoxic Tumors
Carbon-ion radiotherapy is a potential elective treatment option for hypoxic tumors. Its high linear energy transfer enables enhanced cell killing in radiation-resistant tumors, while the Bragg peak ensures precise targeting. Clinical evidence in pancreatic and cervical cancers supports positive outcomes of carbon treatments. However, the power of carbon ions against tumor hypoxia is generally underexploited and should be considered to improve the clinical benefit.
  • 164
  • 15 Sep 2023
Topic Review
Taxane-Based Chemotherapeutic Drugs in Prostate Cancer
Prostate cancer (PCa) is the second most diagnosed cancer and the fourth leading cause of cancer-related death in men in the Western world. Delineation of pathogenetic pathways and key driver molecular alterations involved in PCa development has provided a roadmap for the evaluation of biomarkers in predicting disease outcome and to identify potential therapeutic targets. Chemotherapeutic agents introduced from the 1990s include the taxanes (paclitaxel, docetaxel, and cabazitaxel), which are the anticancer drugs used most frequently for PCa treatment. 
  • 262
  • 15 Sep 2023
Topic Review
Alzheimer’s Disease Genetic Susceptibility
Alzheimer’s disease (AD) is the most common form of dementia that affects millions of individuals worldwide. Although the research over the last decades has provided new insight into AD pathophysiology, there is currently no cure for the disease. AD is often only diagnosed once the symptoms have become prominent, particularly in the late-onset (sporadic) form of AD. Consequently, it is essential to further new avenues for early diagnosis. With advances in genomic analysis and a lower cost of use, the exploration of genetic markers alongside RNA molecules can offer a key avenue for early diagnosis.
  • 221
  • 14 Sep 2023
Topic Review
Environmental Impacts of Nut Consumption
Nuts have shown they are key foods in dietary patterns associated with lower chronic disease risk. Nuts emerge as a significant source of protein in plant-based diets and are a minimally processed and sustainable food. Research in this area is evolving to drive better production methods in varying climate conditions. Nevertheless, nut consumption remains an important contributor to human health. 
  • 366
  • 14 Sep 2023
Topic Review Peer Reviewed
Integrating Positive Psychology into Substance Use Treatments
Positive psychology is a rapidly expanding and recent empirical. interdisciplinary research topic (i.e., within the last 25 years). Early evidence supported that targeting positive variables (i.e., empathy or kindness) has numerous benefits, including improving health outcomes, vocational success, psychological well-being, and interpersonal connectedness. Positive Psychological Interventions (PPIs) are activities and behavioral interventions that target positive variables to promote adaptive functioning (e.g., reducing depression or promoting psychological well-being). PPIs may make excellent contributions to treating substance use, substance use disorders (SUDs), and substance use problems because the interventions can partially shift the notable negative treatment focus (e.g., avoiding the consequences of using) onto positive aspects (e.g., pursuing an ideal future). Current substance use treatment outcomes demonstrate a need for improvements (e.g., low abstinence rates and lifetime symptom remission of SUDs), and positive psychology may provide a framework for improving existing treatments. In the current paper, the author reviewed research supporting the use of PPIs in substance use treatments, provide suggestions for PPI applications, examine advantages and practical issues, outline the current limitations, and provide future directions for continuing this line of work. The author aimed to encourage researchers to advance substance use treatment improvements with positive psychology because the growing consequences from substance use (e.g., the growing frequency of accidental fatal overdose) and the variable, limited treatment outcomes, placing those who use substances in a uniquely vulnerable position.
  • 774
  • 14 Sep 2023
Topic Review
Collagen Hydrolysates
Collagen hydrolysates (CHs) are products with low molecular weight (MW) peptides, and are a result of industrialized processed collagen. Collagen extraction is often a by-product of the meat industry, with the main source for collagen-based products being bovine, although it can also be obtained from porcine and piscine sources. CHs have demonstrated positive results in clinical trials related to joint health, such as decreased joint pain, increased mobility, and structural joint improvements. The bioactivity of CHs is primarily attributed to their bioactive peptide (BAP) content. However, there are significant knowledge gaps regarding the digestion, bioavailability, and bioactivity of CH-derived BAPs, and how different CH products compare in that regard. 
  • 353
  • 14 Sep 2023
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