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Topic Review
Biography
Topic Review
Sarcoidosis-Associated PH According to the Predominant Pathophysiological Mechanism
Sarcoidosis has been a well-recognised risk factor for pulmonary hypertension (PH) for a long time, but still, the knowledge about this concatenation is incomplete. Sarcoidosis-associated PH (SAPH) is an uncommon but serious complication associated with increased morbidity and mortality among sarcoidosis patients.
217
18 Oct 2023
Topic Review
Nasal Nitric Oxide in Children
Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children.
274
18 Oct 2023
Topic Review
PTEN
and Cancer
The PTEN gene is an important and well-characterised tumour suppressor, known to be altered in many cancer types. Interestingly, the effect of the loss or mutation of PTEN is not dichotomous, and small changes in PTEN cellular levels can promote cancer development.
242
18 Oct 2023
Topic Review
Management of Hyperglycemia in Hospitalized Adult Patients
Hyperglycemia (blood glucose > 140 mg/dL or 7.8 mmol/L) in hospitalized patients without a history of diabetes is defined as stress hyperglycemia, and is reported in 32.2% of critically ill patients in intensive care units (ICUs) and 30% of noncritically ill hospitalized patients. Hyperglycemia alters immune response by inhibiting chemotaxis and phagocytosis. It affects the bactericidal ability of immune cells by decreasing the production of superoxide radicals. Hyperglycemia also induces osmotic diuresis, endothelial injury, and mitochondrial dysfunction, which can lead to shock and multiple organ failure in hospitalized patients.
235
18 Oct 2023
Topic Review
Seaweed as a Marine Source for Anti-Inflammatory Activity
Inflammation is a defense mechanism of the body in response to harmful stimuli such as pathogens, damaged cells, toxic compounds or radiation. However, chronic inflammation plays an important role in the pathogenesis of a variety of diseases. Marine organisms produce a broad spectrum of bioactive compounds with anti-inflammatory activities. Several are considered as lead compounds for development into drugs. Anti-inflammatory compounds have been extracted from algae, corals, seaweeds and other marine organisms. Seaweed is a popular food source rich in bioactive compounds, polysaccharides, fatty acids, peptides, proteins and vitamins. Seaweeds have several potential therapeutic activities, including anti-bacterial, anti-viral, anti-cancer, antioxidant and anti-inflammatory.
339
18 Oct 2023
Topic Review
Fertility Preservation Options for Transgender Patients
Fertility preservation technologies have existed for decades, and the field is rapidly advancing; limited data exist regarding the use of these technologies by transgender patients. Many options are available for transgender patients who wish to preserve fertility before transitioning. These options include the cryopreservation of gametes, embryos, or ovarian tissue.
251
18 Oct 2023
Topic Review
Ethical Implications of Chatbot Utilization in Nephrology
In the realm of medicine, chatbots have risen as an instrumental tool, seamlessly enhancing patient interactions, streamlining administrative workflows, and elevating healthcare service quality. Their multifaceted applications span from enlightening patients, sending medication alerts, and assisting with preliminary diagnoses to operational responsibilities such as scheduling visits and gathering patient insights. Their ascendancy is attributed to a mix of elements, such as the widespread use of intelligent devices, amplified internet connectivity, and consistent advancements in AI technologies.
142
18 Oct 2023
Topic Review
Acupuncture in Children Frequent or Chronic Primary Headaches
Acupuncture is a spreading and promising intervention, which has proven to be very useful in the treatment and prevention of chronic pain, in particular chronic headaches, in adults. Despite the differences in tools, procedures, and application sites, acupuncture demonstrated a positive effect on both the frequency and intensity of headaches and was well tolerated.
241
18 Oct 2023
Topic Review
Neonatal Outcomes of Children Born from Frozen Embryo
The growing use of ART (assisted reproductive techniques) has led to a progressive improvement of protocols; embryo freezing is certainly one of the most important innovations. This technique is selectively offered as a tailored approach to reduce the incidence of multiple pregnancies and, most importantly, to lower the risk of developing ovarian hyperstimulation syndrome when used in conjunction with an ovulation-triggering GnRH antagonist. The increase in transfer cycles with frozen embryos made it possible to study the effects of the technique in children thus conceived. Particularly noteworthy is the increase in macrosomal and LGA (large for gestational age) newborns, in addition to a decrease in SGA (small for gestational age) and LBW (low birth weight) newborns.
260
17 Oct 2023
Topic Review
Quercetin Derivatives in Nicotine-Induced Non-Small Cell Lung-Cancer Therapy
Flavonoids are the largest group of polyphenols, represented by many compounds that exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin, isoquercitrin, isorhamnetin, tamarixetin, rhamnetin, and hyperoside) in the class of flavonols have been documented to exert anticancer activity. Q has been shown to be useful in the treatment of non-small cell lung cancer (NSCLC), as demonstrated by in vitro/in vivo studies, due to its antitumor, anti-inflammatory, anti-proliferative, anti-angiogenesis, and apoptotic properties. Some flavonoids (flavone, anthocyanins, and proanthocyanidins) have been demonstrated to be effective in nicotine-induced NSCLC treatment.
249
17 Oct 2023
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