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Topic Review
Selenium-Enriched Foods
Selenium plays important roles in human health, but both selenium deficiency and excess can cause severe harm to humans and animals. Studies have shown that the effects of selenium supplementation depend on its dosage and species. Therefore, it is important to maintain a balanced and scientifical selenium supplementation. In recent years, natural and artificial selenium-enriched foods have been developed as the major sources of dietary selenium supplementation, and various selenium-enriched foods have been demonstrated to exhibit different physiological functions in vitro and in vivo, including antioxidant, anticancer, and anti-inflammatory effects, etc.
  • 190
  • 23 Oct 2023
Topic Review
Deep Learning Methods for Retinal Disease Diagnosis
The advancement of digital medical imaging has brought about a significant change in ophthalmology as it has introduced effective technologies that help in the detection of such diseases. By improving early detection through image analysis and identifying minuscule anomalies, Artificial Intelligence (AI) has considerably coped with retinal diseases. Different Machine Learning (ML) and Convolutional Neural Networks (CNNs) are efficient at analyzing images and are particularly incredible at recognizing complex patterns in medical images.
  • 241
  • 21 Oct 2023
Topic Review
BRCA Mutations in Prostate Cancer
Prostate cancer was the second most common cancer and ranked fifth in causing cancer-related death in men worldwide in 2020. BRCA mutations have been found to be especially clinically relevant with a role for germline or somatic testing. Prostate cancer with DDR defects may be sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors which target proteins in a process called PARylation.
  • 216
  • 20 Oct 2023
Topic Review
Oxidative Stress in the Natural History of Atrial Fibrillation
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence increases with age. The irregular and rapid contraction of the atria can lead to ineffective blood pumping, local blood stasis, blood clots, ischemic stroke, and heart failure. NADPH oxidases (NOX) and mitochondria are the main sources of reactive oxygen species in the heart, and dysregulated activation of NOX and mitochondrial dysfunction are associated with AF pathogenesis. NOX- and mitochondria-derived oxidative stress contribute to the onset of paroxysmal AF by inducing electrophysiological changes in atrial myocytes and structural remodeling in the atria.
  • 819
  • 20 Oct 2023
Topic Review
Role of Sodium-Glucose Co-Transporter 2 Inhibitors
Diabetic kidney disease (DKD) causes a progressive decline in renal function, leading to end-stage kidney disease (ESKD), and increases the likelihood of cardiovascular events and mortality. The introduction of the sodium-glucose co-transporter 2 (SGLT-2) inhibitor has been a game changer in managing chronic kidney disease (CKD) and congestive heart failure (CHF). These agents not only slow down the progression of kidney disease but also have cardioprotective benefits, including for patients with congestive heart failure and atherosclerotic cardiovascular disease. Some evidence suggests that they can decrease the risk of stroke as well.
  • 292
  • 20 Oct 2023
Topic Review
Nanomedicine for Pediatric Healthcare
Pediatrics is the field of medicine that centers on physical, social, and mental health from birth to the end of adolescence. Nanotechnology has received enthusiasm among the scientific community, particularly in medicine and pharmaceutical fields, due to its potential to incorporate diagnostic and treatment tools in the same nanocarrier, enhance targetability to specific organs, decrease toxicity, and potentially reduce treatment schedules. At the same time, it provides a tool to increase patient compliance, which is an essential task concerning the pediatric population.
  • 290
  • 20 Oct 2023
Topic Review
Exosomes as Modulators of Pancreatic Cancer Drug Resistance
Pancreatic cancer (PaC) is one of the most lethal tumors worldwide, difficult to diagnose, and with inadequate therapeutical chances. The most used therapy is gemcitabine, alone or in combination with nanoparticle albumin-bound paclitaxel (nab-paclitaxel), and the multidrug FOLFIRINOX. Unfortunately, PaC develops resistance early, thus reducing the already poor life expectancy of patients. The mechanisms responsible for drug resistance are not fully elucidated, and exosomes seem to be actively involved in this phenomenon, thanks to their ability to transfer molecules regulating this process from drug-resistant to drug-sensitive PaC cells. These extracellular vesicles are released by both normal and cancer cells and seem to be essential mediators of intercellular communications, especially in cancer, where they are secreted at very high numbers.
  • 243
  • 20 Oct 2023
Topic Review
Drug Remedies and Host Cell Responses for COVID-19
In light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either by stopping viral entry or inhibiting viral replication. Repurposing antiviral drugs, typically nucleoside analogs, has proven successful at inhibiting virus replication. 
  • 382
  • 20 Oct 2023
Topic Review
Gonadotropin and Ovarian Hormone Monitoring
FSH, estrogen and progesterone testing are widely utilized in clinical practice. Lateral flow assays (LFAs) are cost-effective tools used for diagnosing infectious diseases, pregnancy, and substance testing.
  • 100
  • 20 Oct 2023
Topic Review
Hyperandrogenism
Hyperandrogenism encompasses a wide range of clinical manifestations, including polycystic ovary syndrome (PCOS), idiopathic hirsutism, hirsutism and hyperandrogaenemia, non-classical congenital adrenal hyperplasia, hyperandrogenism, insulin resistance, acanthosis nigricans (HAIR-AN), ovarian or adrenal androgen-secreting neoplasms, Cushing’s syndrome, and hyperprolactinaemia.
  • 215
  • 20 Oct 2023
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