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Topic Review
Microfluidic Device in Anti-Cancer Drug Screening
Having its root lying in microelectronics, microfluidics seems to hold great potential to explore people's limited knowledge in the field of oncology. It offers numerous advantages such as a low sample volume, minimal cost, parallelization, and portability and has been advanced in the field of molecular biology and chemical synthesis. The platform has been proved to be valuable in cancer research, especially for diagnostics and prognosis purposes and has been successfully employed in recent years. Organ-on-a-chip, a biomimetic microfluidic platform, simulating the complexity of a human organ, has emerged as a breakthrough in cancer research as it provides a dynamic platform to simulate tumor growth and progression in a chip.
  • 1.0K
  • 15 Jul 2022
Topic Review
Tolerogenic Vaccines to Induce Antigen-Specific Tolerance
Conventional therapies for immune-mediated diseases, including autoimmune disorders, transplant reactions, and allergies, have undergone a radical evolution in the last few decades; however, they are still not specific enough to avoid widespread immunosuppression. The idea that vaccine usage could be extended beyond its traditional immunogenic function by encompassing the ability of vaccines to induce antigen-specific tolerance may revolutionize preventive and therapeutic strategies in several clinical fields that deal with immune-mediated disorders. 
  • 1.0K
  • 22 Sep 2022
Topic Review
Therapeutic Targeting of Intestinal Fibrosis in Crohn’s Disease
Intestinal fibrosis is one of the most threatening complications of Crohn’s disease. Endoscopic and surgical approaches are currently the only options available and there is an urgent need for targeted anti-fibrotic therapy. Several molecules investigated in preclinical studies, which are awaiting clinical trials in humans, have proven effective in CD stricturing phenotype and may be available in the near future as additional weapons in preventing or reversing intestinal fibrosis. 
  • 1.0K
  • 24 Mar 2022
Topic Review
Mechanism of Parkinson’s Disease Drugs
Parkinson’s Disease (PD) is a progressive degenerative neurological disorder commonly presenting with symptoms of muscle rigidity, instability, tremor, bradykinesia (slow in movement), and lack of coordination. There are conventional drugs used in treating Parkinson’s disease such as levodopa, dopamine agonists, anticholinergics, catechol-O-methyltransferase (COMT) inhibitors, monoamine oxidase-B (MAO-B) inhibitors, and amantadine. Other drugs used in treating PD related psychosis include antipsychotics. 
  • 1.0K
  • 07 Mar 2022
Topic Review
DYRK kinase family in cancer
       DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes, including those associated with all the hallmarks of cancer. In accordance with an involvement of DYRK kinases in the regulation of tumorigenic processes, an increasing number of research studies are showing either alterations of DYRK gene expression in tumor samples and/or providing evidence of DYRK-dependent mechanisms that contribute to tumor initiation and/or progression.
  • 1.0K
  • 28 Aug 2020
Topic Review
Cation-Chloride Cotransporters
Stroke is one of the major culprits responsible for morbidity and mortality worldwide, and the currently available pharmacological strategies to combat this global disease are scanty. Cation-chloride cotransporters (CCCs) are expressed in several tissues (including neurons) and extensively contribute to the maintenance of numerous physiological functions including chloride homeostasis.
  • 1.0K
  • 07 Feb 2021
Topic Review
Infant Gut Microbiota
Evidence is accumulating which shows that maternal transmission of microbes to the infant gut occurs prenatally, in utero. However, the first big wave of microbial colonization occurs after birth. Gut microbial dysbiosis in infant increase the risk of subsequent asthma through a number of perinatal factors such as diet, delivery mode, antibiotic exposure, maternal asthma during pregnancy and pre-gestational body mass index. Nutrition plays a fundamental role as a potent modifiable factor influencing the human gut microbiota composition, which provides new insights into therapeutic strategies aimed at manipulating the gut microbiota through dietary modification. There is very little evidence to date linking maternal dietary patterns during pregnancy with alterations in the infant gut microbiota. The effect of maternal dietary nutrient intake causes alterations in breast milk microbiota composition. There is however a paucity of human data examining the effects and underlying mechanisms of maternal diet on the infant gut microbiota shaping through the alteration of milk microbiota composition. Further long-term cohort studies are needed where the effect of maternal nutrition during pregnancy and lactation on the infant gut microbiota composition are studied in further detail in context of asthma development and may provide useful insights into potential mechanisms that could potentially reduce the risk of asthma.
  • 1.0K
  • 31 Jul 2020
Topic Review
The Importance of Capsules in Dry Powder Inhalers
Capsule-based dry powder inhalers (cDPI) use a hard capsule that contains a powder formulation which consists of a mixture of a micronized drug and a carrier usually the lactose, known for its good lung tolerance. The capsule is either inserted into the device during manufacturer or by the patient prior to use. After perforating, opening or cut the capsule in the device, patients take a deep and rapid breath to inhale the powder, using air as the vector of drug displacement. The system is simple, relatively cheap and characterized by a lower carbon footprint than that of pressurized metered dose inhalers. 
  • 1.0K
  • 29 Mar 2022
Topic Review
Flavonoids for Health and Longevity
Flavonoids are a diverse family of natural phenolic compounds commonly found in fruits, vegetables, tea, wine, and Chinese herbal medicine. Flavonoids have a basic C6–C3–C6 15 carbon skeleton composed of two aromatic rings and one pyran ring. Flavonoid compounds are divided into six subclasses based on their carbon structure and level of oxidation, which are flavones, flavonols, flavanones, isoflavones, flavanol, and anthocyanins.
  • 1.0K
  • 23 Feb 2022
Topic Review
Platelet in Atherosclerosis Plaque Formation
Besides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially develops at sites under disturbed blood flow with low speeds and chaotic directions. Hyperglycemia, hyperlipidemia, and hypertension are all risk factors for atherosclerosis. When the vascular microenvironment changes, platelets can respond quickly to interact with endothelial cells and leukocytes, participating in atherosclerosis.
  • 1.0K
  • 10 Feb 2021
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