Topic Review
Monochromatic X-rays
Monochromatic X-ray has a single energy level in contrast to white X-rays used in conventional radiation therapy. Irradiation of high Z elements such as gadolinium, gold and silver with a monochromatic X-ray can result in photoelectric effects that includes the release of the Auger electrons that have strong cell killing effect. To apply this principle to cancer therapy, various nanoparticles loaded with high Z elements have been developed that enabled high Z elements to be delivered to tumor. The recent addition is gadolinium-loaded mesoporous silica nanoparticle (Gd-MSN). Tumor spheroids have been used as a convenient tumor model to demonstrate that monochromatic X-rays with energy level at or higher than the K-edge energy of gadolinium can destruct tumor mass that has Gd-MSN distributed throughout tumor spheroids.
  • 8.3K
  • 22 Jul 2020
Topic Review
Creatine Monohydrate
Creatine (N-(aminoiminomethyl)-N-methyl glycine) is a naturally occurring nitrogen-containing compound that plays an integral role in cellular metabolism. Creatine monohydrate (CrM) supplementation increases muscle phosphagen levels, improves repetitive high-intensity exercise performance, and promotes greater training adaptations. No significant side effects other than weight gain have been reported from CrM supplementation despite widespread use throughout the world. 
  • 8.2K
  • 07 Mar 2022
Topic Review
Biomechanics of Table Tennis
Table tennis is a popular recreational and competitive sports at all levels. Recent research on table tennis maneuvers identified the differences between playing levels and between maneuvers using parameters which included ball and racket speed, joint kinematics and kinetics, electromyography, and plantar pressure distribution. Different maneuvers underlined changes on body posture and lines of movement which were accommodated particularly by the racket face angle, trunk rotation, knee and elbow joint movements, and thus different contributions of muscles. Higher-level players produced ball and strike at higher accuracy and repeatability but not necessarily lead to higher speed. In addition, higher-level players utilize superior whole-body coordination and footwork to compromise between agility and stability for a quality strike. Strengthening shoulder and wrist muscles could enhance the speed of the strike while personalized training shall be considered since motor coordination and adaptation vary among individuals.
  • 8.1K
  • 29 Oct 2020
Topic Review
Information Problem-Solving Instruction
Information problem solving (IPS) is a complex cognitive process considered as an important 21st century skill in combination with critical thinking [15].
  • 8.1K
  • 27 Oct 2020
Topic Review
Physico-Chemical Properties of Sodium Alginate
The macromolecules of natural origin have attracted the attention of many researchers as essential to protect the structures of unstable drug substances. After analyzing the studies carried out by various authors, researchers found that these molecules are used for both investigational and therapeutic purposes. This requires the design of certain drug delivery formulations knowing the nature of the macromolecule, its target organ, the required dose and the route of delivery. Therefore, researchers consider it important to use sodium alginate to optimize the delivery of drug substances for maximum therapeutic performance in the body after administration.
  • 8.0K
  • 19 Oct 2022
Topic Review
Burnout and Personal Accomplishment
Research on burnout has traditionally focused on job demands, with less attention paid to protective factors. From the emerging and innovative area of psychology of sustainability and sustainable development, the relationship that job demands (workload), and personal resources (psychological capital) have with burnout was analyzed. Results show that (1) psychological capital and workload are related to burnout, and (2) personal accomplishment is more a personal resource than burnout dimension. The results confirm the role of psychological capital as a protective factor for burnout.
  • 7.9K
  • 27 Oct 2020
Topic Review
Clavicular Malignancies
The clavicle, or collar bone, is a long (6 inches in adults), tubular, S-shaped bone that is subcutaneous throughout and can be considered “special” for several reasons. It is the first bone to ossify in the embryo, with its two first ossification centers developing between the fifth and sixth weeks of gestation. Malignant clavicular tumors present with local pain, a palpable firm mass or pathological bone fracture, or with the clinical symptoms of the primary tumor (in cases of metastasis).
  • 7.9K
  • 20 Jul 2022
Topic Review
List of Anatomy Mnemonics
This is a list of human anatomy mnemonics, categorized and alphabetized. For mnemonics in other medical specialties, see this list of medical mnemonics.
  • 7.4K
  • 24 Nov 2022
Topic Review
Melanogenesis
Melanogenesis is the biological and biochemical process of melanin and melanosome biosynthesis. Melanin is formed by enzymic reactions of tyrosinase family proteins that convert tyrosine to form brown-black eumelanin and yellow-red pheomelanin within melanosomal compartments in melanocytes, following the cascades of events interacting with a series of autocrine and paracrine signals. Fully melanized melanosomes are delivered to keratinocytes of the skin and hair. In humans, eumelanin and pheomelanin are mixed together regardless of the pigmentary phenotype. The ratio of the two melanin pigments is determined by race and/or specific genetic variations. On the other hand, many mammals have various patterns of hair coat color that can be changed temporally. Wild type mice have agouti pattern hair caused by a mechanism, called pigment-type switching.
  • 7.3K
  • 27 Oct 2020
Topic Review
Vitamin B6 and Diabetes
Vitamin B6 is an essential nutrient for the human health. It is involved in more that 150 metabolic reactions which regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, vitamin B6 is an antioxidant molecule able to  counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products (AGEs). Epidemiological and experimental studies indicated the reduced levels of vitamin B6 can cause diabetes. In contrast other studies show that diabetes decreases vitamin B6 levels. Thus these findings lead to envisage the existence of a vicious circle at the basis of the relationship between vitamin B6 and diabetes. This entry reports the main evidence concerning the role of vitamin B6 in diabetes and examine the underlying molecular and cellular mechanisms.  
  • 7.2K
  • 28 Oct 2020
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