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Topic Review
A Simple ANN for Sleep-Waking Recognition
Artificial neural network (ANNs) is a machine learning approach that has rapidly gained popularity due to its ability to quickly and effectively solve complex problems. Sleep monitoring is often required for patients who are suffering from diseases or who are undergoing treatment. Recently, in a paper described a new method for the automatic recognition of behavioral sleep and waking states in freely moving rats. This is a simple ANN, in which the mean values and standard deviations of electrocorticograms. ANN was trained to recognize sleep and waking states with the accuracy of 80%. 
  • 351
  • 20 Jun 2023
Topic Review
A Smarter Health through Internet of Surgical Things
To systematically study the technological advances in a particular sector, attributed to the utilization of the Internet, the term “Internet of Things” (IoT) was introduced. The present systematic review, aims to present and analyze the modern applications of the IoT within the surgical world. While not strictly defined, IoT describes a network of Internet-based connected things equipped with (embedded) sensing and actuating devices, with data production, processing, and consumption abilities. The utilization of the Internet and IoT in medical practice can take many shapes and forms. Ranging from the awe-inspiring telesurgical procedures to complex AI machine learning applications that aid in medical decision making , to a simple email containing a preoperative CT scan, the Internet of Surgical Things (IoST) is here to stay. 
  • 1.1K
  • 04 Jul 2022
Topic Review Peer Reviewed
A Systematic Review of Effects on ACL Injury of Soccer Shoe Outsoles, Soccer Playing Field Surfaces, and Outsole–Surface Interface
Soccer is a sport with a high incidence of injuries. The most common injury occurs when the anterior cruciate ligament of the knee has undergone a sprain, strain, or partial or total rupture. Besides fitness factors (e.g., proprioception, balance and strength capabilities), a principal cause of ACL injuries is sport shoes and playing surfaces. Especially with the emergence of artificial surfaces (rubbers, turfs, concrete, asphalt, red turf), the ACL injuries dramatically increase. The cost of ACL injuries is high both in terms of career termination and in social and economic costs. Thus, it is necessary to understand the impact of sport shoes and playing surfaces on the ACL and how it can be mitigated. The present literature review followed the PRISMA methodology to identify the major biomechanical factors influencing the behavior of surfaces and shoes in relation to the ACL damage. Fifty-eight papers were identified. After reviewing the mechanism of injuries, we identified several distinct factors: type of outsole and mechanical arrangement of the outsoles; shear forces; characteristics of artificial turf surfaces; effect of weather on artificial surface aging and change in mechanical characteristics; outsole/ground interface; and the frictional, tractional and rotational forces in the pathogenesis of ACL injuries in soccer.
  • 326
  • 28 May 2024
Topic Review
A Theranostic Approach in Selective Internal Radiation Therapy
Selective internal radiation therapy (SIRT) is one of the treatment options for liver tumors. Microspheres labelled with a therapeutic radionuclide (90Y or 166Ho) are injected into the liver artery feeding the tumor(s), usually achieving a high tumor absorbed dose and a high tumor control rate. This treatment adopts a theranostic approach with a mandatory simulation phase, using a surrogate to radioactive microspheres (99mTc-macroaggregated albumin, MAA) or a scout dose of 166Ho microspheres, imaged by single photon emission computed tomography (SPECT)/CT.
  • 438
  • 03 Jan 2023
Topic Review
A2B Adenosine Receptors
Adenosine is a signalling molecule which, by activating specific membrane receptors, acts as an important player during brain insults such as ischemia. or demyelinating injuries. Here we review data in the literature describing A2B receptor-mediated effects in preclinical in vitro and in vivo models of cerebral ischemia and myelination that point to A2B receptor ligands as putative therapeutic targets for the still unmet treatment of stroke or demyelinating diseases.
  • 659
  • 14 Apr 2021
Topic Review
AAA 400 Drive for Autism
The AAA 400 Drive for Autism is a 400-mile (640 km) Monster Energy NASCAR Cup Series stock car race held annually at Dover International Speedway in Dover, Delaware, the other one being the Dover 400, the fall race at Dover, for the NASCAR Chase for the Championship, it is the first of two Monster Energy NASCAR Cup Series races at Dover. The 2007 Autism Speaks 400 presented by Visa marked the first time that a NASCAR Cup race entitlement was dedicated to a non-profit organization, by the race's title sponsor, Visa Inc. Starting in 2007 through 2017, Dover International Speedway announced that the 2007 race would be named the “Autism Speaks 400 presented by Visa" , dedicating to increasing understanding and knowledge of autism spectrum disorders; to funding dedicated to eugenics; and to advocating for the needs of affected families. Between 2001 and 2006, the race was broadcast in the United States on FX. Television coverage of the race moved to the Fox network beginning in 2007, but after eight years, the race returned to cable television with Fox Sports 1.
  • 308
  • 08 Nov 2022
Topic Review
AAZTA-Derived Chelators as Innovative Radiopharmaceuticals
The chelating agent AAZTA features a mesocyclic seven-membered diazepane ring, conferring some of the properties of both acyclic and macrocyclic chelating agents. Described in the early 2000s, AAZTA and its derivatives exhibited interesting properties once complexed with metals and radiometals, combining a fast kinetic of formation with a slow kinetic of dissociation. Importantly, the extremely short coordination reaction times allowed by AAZTA derivatives were particularly suitable for short half-life radioelements (i.e., 68Ga).
  • 810
  • 28 Feb 2022
Topic Review
ABC
ABC and its variations are initialism mnemonics for essential steps used by both medical professionals and lay persons (such as first aiders) when dealing with a patient. In its original form it stands for Airway, Breathing, and Circulation. The protocol was originally developed as a memory aid for rescuers performing cardiopulmonary resuscitation, and the most widely known use of the initialism is in the care of the unconscious or unresponsive patient, although it is also used as a reminder of the priorities for assessment and treatment of patients in many acute medical and trauma situations, from first-aid to hospital medical treatment. Airway, breathing, and circulation are all vital for life, and each is required, in that order, for the next to be effective. Since its development, the mnemonic has been extended and modified to fit the different areas in which it is used, with different versions changing the meaning of letters (such as from the original 'Circulation' to 'Compressions') or adding other letters (such as an optional "D" step for Disability or Defibrillation). In 2010, the American Heart Association and International Liaison Committee on Resuscitation changed the recommended order of CPR interventions for most cases of cardiac arrest to chest compressions, airway, and breathing, or CAB.
  • 1.8K
  • 22 Nov 2022
Topic Review
ABC Transporters in the Innate Immune System
The ATP-binding cassette transporters (ABC transporters) are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes. It is of interest to note that many ABC transporters are involved in the transport of various lipids. In addition, this function may be related to the innate immune system. 
  • 752
  • 22 Dec 2022
Topic Review
ABCG2 in Acute Myeloid Leukemia
ABCG2 is an efflux transporter responsible for inducing multidrug resistance (MDR) in leukemic cells; through its ability to extrude many antineoplastic drugs, it leads to AML resistance and/or relapse. Moreover, ABCG2 may be co-expressed with other MDR-related proteins and is finely regulated by epigenetic mechanisms. 
  • 324
  • 25 May 2023
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